SEPN
Q4 2026 EPS Estimate
$-0.52
Nov 9, 2026
Revenue Estimate
$19M

Analyst Sentiment

Wall St. Consensus
Buy
9 analysts·Limited coverage
78
Score
9 Buy (100%)0 Hold (0%)0 Sell (0%)
Rating Breakdown
Strong Buy
111%
Buy
889%
Hold
00%
Sell
00%
Strong Sell
00%

Analyst ratings reflect Wall Street opinion, not guarantees. Historical accuracy varies by firm and sector.

Price Target Expectations

Bear
$43.00
-2.1%
Consensus
$50.00
+13.8%
Bull
$60.00
+36.6%
12-Month Target Range9 analysts
$43.00$50.00$60.00
Current $43.93Consensus
Current Price
$43.93
Upside to Consensus
$6.07

Price targets are 12-month analyst forecasts. Actual results depend on earnings, market conditions, and sector trends.

Earnings & Revenue Estimates

Forward Growth Estimates (YoY)
FY2027
Rev-14.47%
EPS
FY2028
Rev+0.88%
EPS
FY2029
Rev-16.87%
EPS
Raw consensus estimates (low / average / high) from covering analysts.
Annual
MetricFY2026EFY2027EFY2028EFY2029EFY2030E
Revenue Avg$77M$66M$66M$55M$93M
Low$28M$34M$32M$27M$45M
High$123M$82M$89M$74M$125M
EBITDA Avg$-38M$-33M$-33M$-28M$-47M
Low$-62M$-41M$-45M$-37M$-63M
High$-14M$-17M$-16M$-13M$-23M
EBIT Avg$-38M$-33M$-33M$-28M$-47M
Low$-62M$-41M$-45M$-37M$-63M
High$-14M$-17M$-16M$-13M$-23M
Net Income Avg$-67M$-105M$-123M$-172M$-177M
Low$-134M$-157M$-168M$-249M$-255M
High$-23M$-51M$-83M$-56M$-58M
EPS Avg$-1.65$-2.39$-2.73$-3.89$-3.99
Low$-3.02$-3.54$-3.79$-5.62$-5.76
High$-0.53$-1.16$-1.89$-1.27$-1.31
Analysts (Rev / EPS)8 / 67 / 67 / 63 / 35 / 2
Quarterly
MetricQ3 2026Q4 2026Q1 2027Q2 2027Q3 2027Q4 2027
Revenue Avg$19M$21M$9M$9M$9M$9M
Low$10M$20M$5M$5M$5M$5M
High$28M$22M$13M$13M$13M$13M
EBITDA Avg$-10M$-10M$-5M$-5M$-5M$-5M
Low$-14M$-11M$-7M$-7M$-7M$-7M
High$-5M$-10M$-2M$-2M$-2M$-2M
EBIT Avg$-10M$-10M$-5M$-5M$-5M$-5M
Low$-14M$-11M$-7M$-7M$-7M$-7M
High$-5M$-10M$-2M$-2M$-2M$-2M
Net Income Avg$-21M$-22M$-37M$-36M$-40M$-41M
Low$-33M$-27M$-59M$-59M$-65M$-67M
High$-8M$-15M$-15M$-15M$-16M$-17M
EPS Avg$-0.48$-0.49$-0.81$-0.81$-0.90$-0.92
Low$-0.72$-0.60$-1.31$-1.30$-1.44$-1.48
High$-0.17$-0.33$-0.33$-0.33$-0.36$-0.37
Analysts (Rev / EPS)6 / 510 / 39 / 19 / 19 / 19 / 1

Earnings Surprises

Recent Analyst Actions

Aug 12, 2026H.C. Wainwright
Septerna price target raised to $60 from $40 at H.C. Wainwright
Target:$60.00
+25.6%from $47.76
Aug 11, 2026Raymond James
Septerna price target raised to $49 from $45 at Raymond James
Target:$49.00
+9.1%from $44.91
Aug 11, 2026Stifel Nicolaus
Septerna Inc (SEPN) PT Raised to $49 at Stifel
Target:$49.00
+16.3%from $42.14
Aug 11, 2026Guggenheim
Septerna price target raised to $51 from $45 at Guggenheim
Target:$51.00
+31.3%from $38.85
Jul 1, 2026Guggenheim
Septerna Inc (SEPN) PT Lowered to $45 at GuggenheimMember Login
Target:$45.00
+34.4%from $33.49
Jul 1, 2026Truist Financial
Septerna Inc (SEPN) PT Raised to $43 at Truist SecuritiesMember Login
Target:$43.00
+28.4%from $33.49
Jun 11, 2026Guggenheim
Septerna initiated with a Buy at Guggenheim
Target:$52.00
+70.7%from $30.47
Jun 8, 2026Raymond James
Septerna price target raised to $53 from $47 at Raymond James
Target:$53.00
+70.1%from $31.15
Mar 10, 2026Cantor Fitzgerald
Cantor Fitzgerald Reiterates Overweight Rating on Septerna Inc (SEPN)
Target:$60.00
+113.8%from $28.06
Jan 20, 2026H.C. Wainwright
Septerna price target raised to $35 from $30 at H.C. Wainwright
Target:$35.00
+34.3%from $26.07
Dec 19, 2025Raymond James
Septerna initiated with a Strong Buy at Raymond James
Target:$38.00
+38.0%from $27.54
Dec 15, 2025Truist Financial
Septerna initiated with a Buy at Truist
Target:$34.00
+33.5%from $25.47
Nov 14, 2025Wells Fargo
Septerna upgraded to Overweight from Equal Weight at Wells Fargo
Target:$28.00
+45.5%from $19.24
May 16, 2025Wells Fargo
Septerna price target raised to $18 from $11 at Wells Fargo
Target:$18.00
+82.9%from $9.84
Mar 28, 2025Wells Fargo
Septerna price target lowered to $11 from $14 at Wells Fargo
Target:$11.00
+80.3%from $6.10
Feb 18, 2025Wells Fargo
Wells Fargo downgrades Septerna after lead program SEP-786 discontinued
Target:$14.00
+8.0%from $12.96
Data is provided for informational purposes only and does not constitute investment advice. Past performance is not indicative of future results.