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Today's biggest gainers and losers
| Holder | Shares | Date | Change | % Held |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 17.96M | Jun 30, 26 | +8.10M | 36.73% |
| VIKING GLOBAL INVESTORS LP | 2.60M | Jun 30, 26 | +2.60M | 5.33% |
| Blackstone Inc. | 2.40M | Jun 30, 26 | +2.40M | 4.92% |
| 5AM Venture Management, LLC | 2.35M | Jun 30, 26 | -- | 4.81% |
| VR Adviser, LLC | 2.04M | Jun 30, 26 | +434.03K | 4.18% |
| FRANKLIN RESOURCES INC | 2.00M | Jun 30, 26 | +1.48M | 4.09% |
| Caligan Partners LP | 1.74M | Jun 30, 26 | +1.74M | 3.55% |
| VANGUARD CAPITAL MANAGEMENT LLC | 981.82K | Jun 30, 26 | +774.13K | 2.01% |
| Samsara BioCapital, LLC | 954.86K | Jun 30, 26 | +954.86K | 1.95% |
| Blue Owl Capital Holdings LP | 874.54K | Jun 30, 26 | +874.54K | 1.79% |
| Propel Bio Management, LLC | 696.44K | Jun 30, 26 | +550.07K | 1.42% |
| BlackRock, Inc. | 694.73K | Jun 30, 26 | +481.34K | 1.42% |
| CITADEL ADVISORS LLC | 609.38K | Jun 30, 26 | +593.51K | 1.25% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 525.00K | Jun 30, 26 | +525.00K | 1.07% |
| GEODE CAPITAL MANAGEMENT, LLC | 353.85K | Jun 30, 26 | +252.15K | 0.72% |
| BOOTHBAY FUND MANAGEMENT, LLC | 314.38K | Jun 30, 26 | +314.38K | 0.64% |
| Nantahala Capital Management, LLC | 300.00K | Jun 30, 26 | +300.00K | 0.61% |
| Revelation Capital Management, LLC | 299.31K | Jun 30, 26 | -- | 0.61% |
| Alyeska Investment Group, L.P. | 273.62K | Jun 30, 26 | +173.62K | 0.56% |
| ACUTA CAPITAL PARTNERS, LLC | 260.42K | Jun 30, 26 | +260.42K | 0.53% |
| KVP Capital Advisors, LP | 200.00K | Jun 30, 26 | +200.00K | 0.41% |
| WELLINGTON MANAGEMENT GROUP LLP | 194.11K | Jun 30, 26 | -- | 0.40% |
| UBS Group AG | 184.02K | Jun 30, 26 | +182.49K | 0.38% |
| SEVEN GRAND MANAGERS, LLC | 175.00K | Jun 30, 26 | +175.00K | 0.36% |
| STATE STREET CORP | 165.76K | Jun 30, 26 | +129.94K | 0.34% |
| RENAISSANCE TECHNOLOGIES LLC | 151.00K | Jun 30, 26 | +70.96K | 0.31% |
| VANGUARD FIDUCIARY TRUST CO | 148.39K | Jun 30, 26 | +115.58K | 0.30% |
| ADAR1 Capital Management, LLC | 118.62K | Jun 30, 26 | +118.62K | 0.24% |
| Simplify Asset Management Inc. | 101.36K | Jun 30, 26 | +78.13K | 0.21% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85.00K | Jun 30, 26 | +50.00K | 0.17% |
| TWO SIGMA INVESTMENTS, LP | 78.58K | Jun 30, 26 | -36.47K | 0.16% |
| NORTHERN TRUST CORP | 76.42K | Jun 30, 26 | +64.22K | 0.16% |
| DAFNA Capital Management LLC | 67.10K | Jun 30, 26 | +67.10K | 0.14% |
| Quadrature Capital Ltd | 49.34K | Jun 30, 26 | +49.34K | 0.10% |
| DIMENSIONAL FUND ADVISORS LP | 44.81K | Jun 30, 26 | +24.45K | 0.09% |
| XTX Topco Ltd | 42.51K | Jun 30, 26 | +22.24K | 0.09% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 31.11K | Jun 30, 26 | +31.11K | 0.06% |
| Velan Capital Investment Management LP | 25.00K | Jun 30, 26 | -- | 0.05% |
| ACADIAN ASSET MANAGEMENT LLC | 22.94K | Jun 30, 26 | +22.94K | 0.05% |
| Atom Investors LP | 22.85K | Jun 30, 26 | +22.85K | 0.05% |
| BAILARD, INC. | 20.70K | Jun 30, 26 | -- | 0.04% |
| Spark Investment Management LLC | 16.50K | Jun 30, 26 | +16.50K | 0.03% |
| GOLDMAN SACHS GROUP INC | 15.78K | Jun 30, 26 | +4.32K | 0.03% |
| Squarepoint Ops LLC | 14.86K | Jun 30, 26 | +14.86K | 0.03% |
| ALLIANCEBERNSTEIN L.P. | 13.98K | Jun 30, 26 | +13.98K | 0.03% |
| Vanguard Global Advisers, LLC | 11.98K | Jun 30, 26 | +11.98K | 0.02% |
| Sixth Street Partners Management Company, L.P. | 11.90K | Jun 30, 26 | +11.90K | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11.90K | Jun 30, 26 | +11.90K | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | 6.10K | Jun 30, 26 | +6.10K | 0.01% |
| Russell Investments Group, Ltd. | 5.86K | Jun 30, 26 | +370 | 0.01% |
| WELLS FARGO & COMPANY/MN | 5.48K | Jun 30, 26 | +3.98K | 0.01% |
| State of Wyoming | 4.59K | Jun 30, 26 | +4.59K | 0.01% |
| JPMORGAN CHASE & CO | 4.19K | Jun 30, 26 | +3.97K | 0.01% |
| FMR LLC | 3.56K | Jun 30, 26 | +29 | 0.01% |
| BARCLAYS PLC | 3.34K | Jun 30, 26 | +3.34K | 0.01% |
| ROYAL BANK OF CANADA | 3.07K | Jun 30, 26 | +2.88K | 0.01% |
| RHUMBLINE ADVISERS | 3.04K | Jun 30, 26 | +3.04K | 0.01% |
| MORGAN STANLEY | 2.21K | Jun 30, 26 | -14.16K | 0.00% |
| CITIGROUP INC | 2.14K | Jun 30, 26 | +2.14K | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2.14K | Jun 30, 26 | +2.14K | 0.00% |
| Federation des caisses Desjardins du Quebec | 2.00K | Jun 30, 26 | +2.00K | 0.00% |
| China Universal Asset Management Co., Ltd. | 1.60K | Jun 30, 26 | +1.60K | 0.00% |
| BNP PARIBAS ARBITRAGE, SNC | 1.15K | Jun 30, 26 | +606 | 0.00% |
| Legal & General Group Plc | 566 | Jun 30, 26 | +566 | 0.00% |
| Steward Partners Investment Advisory, LLC | 500 | Jun 30, 26 | +500 | 0.00% |
| Ameritas Investment Partners, Inc. | 421 | Jun 30, 26 | +421 | 0.00% |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | Jun 30, 26 | -- | 0.00% |
| Tower Research Capital LLC (TRC) | 247 | Jun 30, 26 | +247 | 0.00% |
| US BANCORP \DE\ | 235 | Jun 30, 26 | +235 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | 200 | Jun 30, 26 | +200 | 0.00% |
| Quarry LP | 94 | Jun 30, 26 | +94 | 0.00% |
| Sterling Capital Management LLC | 72 | Jun 30, 26 | +72 | 0.00% |
| Caitong International Asset Management Co., Ltd | 13 | Jun 30, 26 | +13 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | 11 | Jun 30, 26 | +11 | 0.00% |
| ADVISOR GROUP HOLDINGS, INC. | -- | Jun 30, 26 | -18 | -- |
| JANE STREET GROUP, LLC | -- | Jun 30, 26 | -39.50K | -- |
| MILLENNIUM MANAGEMENT LLC | -- | Jun 30, 26 | -123.27K | -- |
| Sanctuary Advisors, LLC | -- | Jun 30, 26 | -21.58K | -- |
| venBio Partners LLC | -- | Jun 30, 26 | -531.34K | -- |
| OMERS ADMINISTRATION Corp | -- | Jun 30, 26 | -11.40K | -- |
| PANAGORA ASSET MANAGEMENT INC | -- | Jun 30, 26 | -30.70K | -- |
| VANGUARD GROUP INC | 246.01K | Dec 31, 25 | +86.89K | 0.50% |
| Nuveen Asset Management, LLC | 18.61K | Dec 31, 24 | -- | 0.04% |
