Ionis Pharmaceuticals, Inc.IONSNASDAQ
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Net Debt Over TimeElevated
Percentile Rank100
3Y CAGR+27.1%
5Y CAGR+34.4%
Studio
Year-over-Year Change

Total debt minus cash and cash equivalents

3Y CAGR
+27.1%/yr
vs +31.7%/yr prior
5Y CAGR
+34.4%/yr
Recent deceleration
Acceleration
-4.7pp
Decelerating
Percentile
P100
Near historical high
vs 5Y Ago
4.4x
Strong expansion
Streak
2 yr
Consecutive growthElevated
PeriodValueYoY Change
2025$2.24B+90.9%
2024$1.17B+11.4%
2023$1.05B-3.5%
2022$1.09B+186.2%
2021$381.86M-25.3%
2020$511.26M+476.4%
2019$88.70M-75.6%
2018$362.99M-21.9%
2017$464.87M-5.0%
2016$489.37M-