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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Feb 1, 22 | Katz Richard D | CFO | Purchase | -- | 255.00K | -- | 255.00K |
| Feb 1, 22 | BRENNER LOUIS MD | CEO | Purchase | -- | 655.00K | -- | 655.00K |
| Nov 15, 21 | BRENNER LOUIS MD | CEO | Purchase | -- | 125.58K | -- | 328.90K |
| Nov 15, 21 | BRENNER LOUIS MD | CEO | Sale | $0.81 | 40.33K | $32.67K | 288.58K |
| Nov 15, 21 | BRENNER LOUIS MD | CEO | Sale | -- | 125.58K | -- | -- |
| Jun 3, 21 | Margolin Alexey L | CTO | Purchase | $1.14 | 37.00K | $42.18K | 37.00K |
| Jun 3, 21 | Alexander Robert | CTO | Purchase | $1.14 | 37.00K | $42.18K | 37.00K |
| Jun 3, 21 | Diaz Allene M. | CTO | Purchase | $1.14 | 37.00K | $42.18K | 37.00K |
| Jun 3, 21 | SANTINI GINO | CTO | Purchase | $1.14 | 37.00K | $42.18K | 37.00K |
| Jun 3, 21 | Miller Ann Calby | CTO | Purchase | $1.14 | 37.00K | $42.18K | 37.00K |
| May 10, 21 | BRENNER LOUIS MD | COO | Purchase | -- | 83.72K | -- | 228.54K |
| May 10, 21 | BRENNER LOUIS MD | COO | Sale | $1.11 | 25.21K | $27.99K | 203.32K |
| May 10, 21 | BRENNER LOUIS MD | COO | Sale | -- | 83.72K | -- | 125.58K |
| Apr 6, 21 | Fitzpatrick Mark J. | CTO | Purchase | $1.31 | 74.00K | $96.94K | 74.00K |
| Apr 6, 21 | Fitzpatrick Mark J. | CTO | Sale | -- | -- | -- | 5.00K |
| Feb 16, 21 | BRENNER LOUIS MD | COO | Purchase | $2.10 | 886.40K | $1.86M | 886.40K |
| Feb 1, 21 | Katz Richard D | CFO | Purchase | $1.67 | 400.00K | $668.00K | 400.00K |
| Jan 29, 21 | Katz Richard D | Officer | Sale | -- | -- | -- | -- |
| Dec 17, 20 | WHOLIHAN EDWARD | CFO | Purchase | -- | 164.82K | -- | 189.82K |
| Dec 17, 20 | WHOLIHAN EDWARD | CFO | Sale | $1.36 | 68.55K | $93.23K | 121.27K |
| Dec 17, 20 | WHOLIHAN EDWARD | CFO | Sale | -- | 164.82K | -- | -- |
| Dec 17, 20 | BRENNER LOUIS MD | CEO | Purchase | -- | 247.93K | -- | 247.93K |
| Dec 17, 20 | BRENNER LOUIS MD | CEO | Sale | $1.36 | 103.12K | $140.24K | 144.82K |
| Dec 17, 20 | BRENNER LOUIS MD | CEO | Sale | -- | 247.93K | -- | -- |
| Dec 9, 20 | BRENNER LOUIS MD | COO | Purchase | -- | 209.30K | -- | 209.30K |
| Nov 17, 20 | Topper James N | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Nov 17, 20 | SANTINI GINO | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Nov 17, 20 | Margolin Alexey L | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Nov 17, 20 | Hack Andrew A. F. | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Nov 17, 20 | Diaz Allene M. | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Nov 17, 20 | Alexander Robert | CTO | Purchase | $1.45 | 14.00K | $20.30K | 14.00K |
| Oct 5, 20 | Miller Ann Calby | CTO | Purchase | $1.69 | 28.00K | $47.32K | 28.00K |
| Oct 5, 20 | Miller Ann Calby | CTO | Sale | -- | -- | -- | -- |
| May 28, 20 | BRENNER LOUIS MD | CEO | Purchase | -- | 123.97K | -- | 123.97K |
| May 28, 20 | WHOLIHAN EDWARD | CFO | Purchase | -- | 82.41K | -- | 82.41K |
| Dec 2, 19 | WHOLIHAN EDWARD | CFO | Purchase | $2.42 | 153.00K | $370.26K | 153.00K |
| Dec 2, 19 | WHOLIHAN EDWARD | CFO | Purchase | -- | 82.41K | -- | 82.41K |
| Dec 2, 19 | BRENNER LOUIS MD | CEO | Purchase | $2.42 | 375.00K | $907.50K | 375.00K |
| Dec 2, 19 | BRENNER LOUIS MD | CEO | Purchase | -- | 123.97K | -- | 123.97K |
| Jun 5, 19 | Topper James N | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| Jun 5, 19 | TEPPER ROBERT I | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| Jun 5, 19 | SANTINI GINO | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| Jun 5, 19 | Margolin Alexey L | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| Jun 5, 19 | Hack Andrew A. F. | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| Jun 5, 19 | Alexander Robert | CTO | Purchase | $5.59 | 14.00K | $78.26K | 14.00K |
| May 6, 19 | Diaz Allene M. | CTO | Purchase | $6.42 | 28.00K | $179.76K | 28.00K |
| Apr 15, 19 | Diaz Allene M. | CTO | Sale | -- | -- | -- | -- |
| Mar 4, 19 | WHOLIHAN EDWARD | CFO | Purchase | $6.70 | 125.00K | $837.50K | 125.00K |
| Jan 4, 19 | BRENNER LOUIS MD | COO | Purchase | $7.03 | 305.00K | $2.14M | 305.00K |
| Jun 8, 18 | Topper James N | CTO | Purchase | $13.52 | 10.18K | $137.66K | 10.18K |
| Jun 8, 18 | TEPPER ROBERT I | CTO | Purchase | $13.52 | 10.18K | $137.66K | 10.18K |
| Jun 8, 18 | SANTINI GINO | CTO | Purchase | $13.52 | 10.18K | $137.66K | 10.18K |
| Jun 8, 18 | Bolte Axel | CTO | Purchase | $13.52 | 10.18K | $137.66K | 10.18K |
| Jun 8, 18 | Alexander Robert | CTO | Purchase | $13.52 | 10.18K | $137.66K | 10.18K |
| Jun 8, 18 | Hack Andrew A. F. | CTO | Purchase | $13.52 | 20.36K | $275.32K | 20.36K |
| Jun 8, 18 | Hack Andrew A. F. | CTO | Sale | -- | -- | -- | -- |
| May 9, 18 | WHOLIHAN EDWARD | CFO | Sale | $1.59 | 25.00K | $39.75K | 167.03K |
| May 9, 18 | WHOLIHAN EDWARD | CFO | Purchase | $1.59 | 25.00K | $39.75K | 25.00K |
| Feb 9, 18 | WHOLIHAN EDWARD | CFO | Purchase | $6.91 | 75.00K | $518.25K | 75.00K |
| Feb 9, 18 | BRENNER LOUIS MD | COO | Purchase | $6.91 | 100.00K | $691.00K | 100.00K |
| Feb 9, 18 | Margolin Alexey L | CEO | Purchase | $6.91 | 190.00K | $1.31M | 190.00K |
| Nov 6, 17 | HBM BioCapital II LP | 10 percent owner | Purchase | $14.00 | 71.43K | $999.99K | 1.64M |
| Nov 6, 17 | HBM BioCapital II LP | 10 percent owner | Purchase | -- | 140.84K | -- | 1.57M |
| Nov 6, 17 | HBM BioCapital II LP | 10 percent owner | Purchase | -- | 1.43M | -- | 1.43M |
| Nov 6, 17 | HBM BioCapital II LP | 10 percent owner | Sale | -- | 587.87K | -- | -- |
| Nov 6, 17 | HBM BioCapital II LP | 10 percent owner | Sale | -- | 5.95M | -- | -- |
| Nov 6, 17 | Hadley Harbor Master Investors (Cayman) L.P. | 10 percent owner | Purchase | -- | 757.68K | -- | 757.68K |
| Nov 6, 17 | Hadley Harbor Master Investors (Cayman) L.P. | 10 percent owner | Sale | -- | 3.16M | -- | -- |
| Nov 6, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Purchase | $14.00 | 36.00K | $504.00K | 2.26M |
| Nov 6, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Purchase | -- | 2.23M | -- | 2.23M |
| Nov 6, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Sale | -- | 6.12M | -- | -- |
| Nov 6, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Sale | -- | 3.17M | -- | -- |
| Nov 6, 17 | Topper James N | CTO | Purchase | $14.00 | 500.00K | $7.00M | 3.33M |
| Nov 6, 17 | Topper James N | CTO | Purchase | -- | 254.41K | -- | 2.83M |
| Nov 6, 17 | Topper James N | CTO | Purchase | -- | 1.11M | -- | 2.58M |
| Nov 6, 17 | Topper James N | CTO | Purchase | -- | 1.47M | -- | 1.47M |
| Nov 6, 17 | Topper James N | CTO | Sale | -- | 6.12M | -- | -- |
| Nov 6, 17 | Topper James N | CTO | Sale | -- | 4.63M | -- | -- |
| Nov 6, 17 | Topper James N | CTO | Sale | -- | 1.06M | -- | -- |
| Nov 6, 17 | TEPPER ROBERT I | CTO | Purchase | $14.00 | 215.00K | $3.01M | 2.79M |
| Nov 6, 17 | TEPPER ROBERT I | CTO | Purchase | -- | 2.58M | -- | 2.58M |
| Nov 6, 17 | TEPPER ROBERT I | CTO | Sale | -- | 4.63M | -- | -- |
| Nov 6, 17 | TEPPER ROBERT I | CTO | Sale | -- | 6.12M | -- | -- |
| Nov 6, 17 | Kraus Stephen | CTO | Sale | -- | -- | -- | -- |
| Nov 6, 17 | Kraus Stephen | CTO | Sale | -- | -- | -- | -- |
| Nov 6, 17 | Kraus Stephen | CTO | Purchase | -- | -- | -- | -- |
| Nov 6, 17 | Kraus Stephen | CTO | Purchase | $14.00 | -- | -- | -- |
| Nov 6, 17 | FHM VI, L.L.C. | 10 percent owner | Purchase | $14.00 | 500.00K | $7.00M | 3.33M |
| Nov 6, 17 | FHM VI, L.L.C. | 10 percent owner | Purchase | -- | 2.83M | -- | 2.83M |
| Nov 6, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 4.63M | -- | -- |
| Nov 6, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 6.12M | -- | -- |
| Nov 6, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 1.06M | -- | -- |
| Nov 6, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Purchase | $14.00 | 215.00K | $3.01M | 2.79M |
| Nov 6, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Purchase | -- | 2.58M | -- | 2.58M |
| Nov 6, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Sale | -- | 4.63M | -- | -- |
| Nov 6, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Sale | -- | 6.12M | -- | -- |
| Nov 1, 17 | Bolte Axel | CTO | Sale | $5.72 | 20.36K | $116.48K | -- |
| Nov 1, 17 | WHOLIHAN EDWARD | CFO | Sale | $1.59 | 192.03K | $305.33K | -- |
| Nov 1, 17 | Margolin Alexey L | CEO | Sale | -- | -- | -- | 808.75K |
| Nov 1, 17 | Margolin Alexey L | CEO | Sale | $0.75 | 10.00K | $7.50K | -- |
| Nov 1, 17 | Margolin Alexey L | CEO | Sale | $1.59 | 131.77K | $209.51K | -- |
| Nov 1, 17 | Margolin Alexey L | CEO | Sale | $1.17 | 215.62K | $252.28K | -- |
| Nov 1, 17 | Kraus Stephen | CTO | Sale | $5.72 | 20.36K | $116.48K | -- |
| Nov 1, 17 | Kraus Stephen | CTO | Sale | -- | -- | -- | -- |
| Nov 1, 17 | Kraus Stephen | CTO | Sale | -- | -- | -- | -- |
| Nov 1, 17 | HBM BioCapital II LP | 10 percent owner | Sale | -- | 140.84K | -- | -- |
| Nov 1, 17 | HBM BioCapital II LP | 10 percent owner | Sale | -- | 1.43M | -- | -- |
| Nov 1, 17 | BRENNER LOUIS MD | Officer | Sale | $1.59 | 76.66K | $121.90K | -- |
| Nov 1, 17 | BRENNER LOUIS MD | Officer | Sale | $4.01 | 43.64K | $175.01K | -- |
| Nov 1, 17 | BRENNER LOUIS MD | Officer | Sale | $1.17 | 203.24K | $237.79K | -- |
| Nov 1, 17 | Topper James N | CTO | Sale | -- | 1.11M | -- | -- |
| Nov 1, 17 | Topper James N | CTO | Sale | -- | 254.41K | -- | -- |
| Nov 1, 17 | Topper James N | CTO | Sale | $5.72 | 20.36K | $116.48K | -- |
| Nov 1, 17 | Topper James N | CTO | Sale | -- | 1.47M | -- | -- |
| Nov 1, 17 | Alexander Robert | CTO | Sale | $1.59 | 43.60K | $69.33K | -- |
| Nov 1, 17 | Alexander Robert | CTO | Sale | $5.72 | 10.18K | $58.24K | -- |
| Nov 1, 17 | TEPPER ROBERT I | CTO | Sale | -- | 1.47M | -- | -- |
| Nov 1, 17 | TEPPER ROBERT I | CTO | Sale | -- | 1.11M | -- | -- |
| Nov 1, 17 | TEPPER ROBERT I | CTO | Sale | $5.72 | 20.36K | $116.48K | -- |
| Nov 1, 17 | SANTINI GINO | CTO | Sale | -- | -- | -- | 15.57K |
| Nov 1, 17 | SANTINI GINO | CTO | Sale | $1.17 | 14.37K | $16.82K | -- |
| Nov 1, 17 | SANTINI GINO | CTO | Sale | $1.59 | 14.37K | $22.85K | -- |
| Nov 1, 17 | SANTINI GINO | CTO | Sale | $5.72 | 10.18K | $58.24K | -- |
| Nov 1, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Sale | -- | 1.47M | -- | -- |
| Nov 1, 17 | Bessemer Venture Partners VII L.P. | 10 percent owner | Sale | -- | 760.57K | -- | -- |
| Nov 1, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Sale | -- | 1.47M | -- | -- |
| Nov 1, 17 | Third Rock Ventures II, L.P. | 10 percent owner | Sale | -- | 1.11M | -- | -- |
| Nov 1, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 254.41K | -- | -- |
| Nov 1, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 1.47M | -- | -- |
| Nov 1, 17 | FHM VI, L.L.C. | 10 percent owner | Sale | -- | 1.11M | -- | -- |
| Nov 1, 17 | Hadley Harbor Master Investors (Cayman) L.P. | 10 percent owner | Sale | -- | 757.68K | -- | -- |
