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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Sep 14, 26 | THRIVENT FINANCIAL FOR LUTHERANS | 10 percent owner | Purchase | $25.00 | 240.00K | $6.00M | 240.00K |
| Sep 15, 26 | THRIVENT FINANCIAL FOR LUTHERANS | 10 percent owner | Sale | $25.00 | 360.00K | $9.00M | -- |
| Jul 14, 26 | THRIVENT FINANCIAL FOR LUTHERANS | 10 percent owner | Purchase | $25.00 | 160.00K | $4.00M | 160.00K |
| Jan 1, 26 | Pritchett Kristofer | Officer | Sale | -- | -- | -- | -- |
| May 7, 25 | Perlowitz Jeffrey A. | CTO | Sale | -- | -- | -- | -- |
| May 23, 24 | Shaw John Joseph | CTO | Sale | $14.09 | 7.97K | $112.38K | 22.02K |
| May 23, 24 | Shaw John Joseph | CTO | Sale | $14.09 | 7.90K | $111.34K | 14.12K |
| May 24, 24 | Shaw John Joseph | CTO | Sale | $14.18 | 2.02K | $28.71K | 12.10K |
| May 24, 24 | Shaw John Joseph | CTO | Sale | $14.18 | 2.10K | $29.76K | 10.00K |
| Aug 16, 23 | Shaw John Joseph | CTO | Sale | $12.85 | 9.29K | $119.33K | 50.72K |
| Aug 17, 23 | Shaw John Joseph | CTO | Sale | $12.80 | 20.72K | $265.18K | 30.00K |
| Aug 9, 22 | Orr Elaine | CTO | Sale | -- | -- | -- | -- |
| Mar 17, 22 | SPECTOR BRUCE H | CTO | Purchase | $14.18 | 10.00K | $141.80K | 35.00K |
| Jan 25, 22 | Shaw John Joseph | CTO | Purchase | $15.44 | 26.00K | $401.34K | 60.00K |
| Jan 25, 22 | Shaw John Joseph | CTO | Purchase | $15.34 | 4.00K | $61.37K | 34.00K |
| Sep 15, 21 | THRIVENT FINANCIAL FOR LUTHERANS | CTO | Sale | -- | -- | -- | 400.00K |
| Sep 15, 21 | THRIVENT FINANCIAL FOR LUTHERANS | CTO | Sale | -- | -- | -- | 360.00K |
| Sep 15, 21 | THRIVENT FINANCIAL FOR LUTHERANS | 10 percent owner: | Sale | -- | -- | -- | -- |
| Sep 15, 21 | Sun Life Assurance Co of Canada | CTO | Purchase | $25.00 | 320.00K | $8.00M | 560.00K |
| Jul 15, 21 | Apollo Management Holdings GP, LLC | CTO | Sale | -- | -- | -- | 9.00M |
| Jul 15, 21 | Apollo Management Holdings GP, LLC | CTO | Sale | -- | -- | -- | 6.00M |
| Jul 15, 21 | Apollo Management Holdings GP, LLC | CTO | Sale | -- | -- | -- | 4.00M |
| Jul 15, 21 | Sun Life Assurance Co of Canada | 10 percent owner | Sale | -- | -- | -- | 240.00K |
| Jul 15, 21 | Sun Life Assurance Co of Canada | CTO | Sale | -- | -- | -- | 240.00K |
| Jul 15, 21 | Voya Financial, Inc. | CTO | Sale | -- | -- | -- | 120.00K |
| Feb 16, 21 | Pretlow Paula B | CTO | Sale | -- | -- | -- | -- |
| May 26, 20 | Brufsky Seth J | CEO | Purchase | $11.31 | 20.00K | $226.28K | 69.14K |
| Jan 16, 20 | Shaw John Joseph | CTO | Sale | $15.78 | 5.15K | $81.27K | 30.00K |
| Dec 17, 19 | Morgan Lisa A | Officer | Sale | -- | -- | -- | -- |
| Oct 15, 19 | ARES CAPITAL MANAGEMENT II LLC | CTO | Sale | $14.78 | 8.22K | $121.51K | 59.003 |
| Sep 25, 19 | Bloomstein Joshua M | Officer | Sale | -- | -- | -- | -- |
| Sep 25, 19 | Fitzgerald Ian | Officer | Sale | -- | -- | -- | -- |
| Jun 6, 19 | Sagati Aghili Naseem | Officer | Sale | -- | -- | -- | -- |
| Dec 24, 18 | SPECTOR BRUCE H | CTO | Purchase | $13.30 | 10.00K | $132.99K | 25.00K |
| Dec 24, 18 | Brufsky Seth J | CEO | Purchase | $13.39 | 10.00K | $133.89K | 49.14K |
| Dec 4, 18 | HUNT JAMES KELSO | CTO | Purchase | $14.77 | 2.00K | $29.54K | 7.00K |
| Sep 25, 18 | Arduini Charles JR | Officer | Sale | -- | -- | -- | -- |
| Sep 25, 18 | Milner Samantha | Officer | Sale | -- | -- | -- | -- |
| Sep 25, 18 | Duko Jason | Officer | Sale | -- | -- | -- | -- |
| Sep 25, 18 | Singh Kapil | Officer | Sale | -- | -- | -- | -- |
| Sep 26, 18 | SPECTOR BRUCE H | CTO | Purchase | $15.63 | 3.72K | $58.14K | 15.00K |
| Sep 26, 18 | Shaw John Joseph | CTO | Purchase | $15.56 | 20.00K | $311.13K | 31.46K |
| Jul 10, 18 | Hall Daniel J | Officer | Purchase | $16.00 | 2.50K | $40.00K | 2.50K |
| Dec 21, 16 | HUNT JAMES KELSO | CTO | Purchase | $14.97 | 5.00K | $74.84K | 5.00K |
| Dec 16, 16 | Shaw John Joseph | CTO | Purchase | $14.98 | 10.00K | $149.79K | 10.00K |
| Nov 1, 16 | HUNT JAMES KELSO | CTO | Sale | -- | -- | -- | -- |
| Apr 19, 16 | Reiss M. Freddie | CTO | Purchase | $13.40 | 2.50K | $33.49K | 2.50K |
| Mar 17, 16 | HAYWARD DANIEL ROBERT | Officer | Sale | -- | -- | -- | -- |
| Mar 17, 16 | Lem Scott C | Officer | Sale | -- | -- | -- | -- |
| Sep 15, 15 | McFerran Michael R | Officer | Sale | -- | -- | -- | -- |
| Apr 1, 16 | ROLL PENELOPE F | Officer | Sale | -- | -- | -- | -- |
| Mar 25, 16 | Reiss M. Freddie | CTO | Sale | -- | -- | -- | -- |
| Dec 7, 15 | SACHS DAVID A | CTO | Purchase | $13.52 | 7.50K | $101.40K | 67.19K |
| Dec 7, 15 | SACHS DAVID A | CTO | Purchase | $13.52 | 7.50K | $101.40K | 64.65K |
| Aug 31, 15 | SACHS DAVID A | CTO | Purchase | $21.02 | 13.35K | $280.59K | 57.15K |
| Aug 31, 15 | SACHS DAVID A | CTO | Purchase | $21.02 | 15.90K | $334.16K | 20.99K |
| Aug 31, 15 | Margolies Gregory A | CTO | Purchase | $21.02 | 6.07K | $127.53K | 21.41K |
| Aug 31, 15 | SPECTOR BRUCE H | CTO | Purchase | $21.02 | 7.28K | $153.05K | 11.28K |
| Aug 31, 15 | Eanes John | President | Purchase | $21.02 | 606 | $12.74K | 606 |
| Aug 31, 15 | Ashton Keith | President | Purchase | $21.02 | 424 | $8.91K | 1.29K |
| Aug 31, 15 | Ashton Keith | President | Purchase | $21.02 | 424 | $8.91K | 1.01K |
| Aug 31, 15 | RESSLER ANTONY P | CTO | Purchase | $21.02 | 168.93K | $3.55M | 287.16K |
| Aug 31, 15 | Brufsky Seth J | CEO | Purchase | $21.02 | 17.28K | $363.17K | 38.91K |
| Aug 17, 15 | Ashton Keith | President | Purchase | $15.00 | 445 | $6.67K | 1.01K |
| Aug 17, 15 | Ashton Keith | President | Purchase | $14.96 | 447 | $6.69K | 868 |
| Jul 21, 15 | Brufsky Seth J | CEO | Purchase | $15.37 | 2.50K | $38.42K | 21.49K |
| Oct 16, 14 | Margolies Gregory A | CTO | Purchase | $16.70 | 10.00K | $167.00K | 15.34K |
| Sep 24, 14 | Byrd Brett Alan | Officer | Sale | -- | -- | -- | 32.821 |
| May 5, 14 | Ashton Keith | President | Purchase | $18.45 | 145 | $2.68K | 566 |
| May 5, 14 | Ashton Keith | President | Purchase | $18.45 | 145 | $2.68K | 421 |
| Apr 16, 14 | RESSLER ANTONY P | CTO | Purchase | $18.07 | 9.35K | $168.94K | 31.58K |
| Mar 28, 14 | SACHS DAVID A | CTO | Purchase | $18.14 | 700 | $12.69K | 43.80K |
| Mar 28, 14 | SACHS DAVID A | CTO | Purchase | $18.16 | 1.00K | $18.16K | 43.10K |
| Mar 24, 14 | SPECTOR BRUCE H | CTO | Purchase | $18.35 | 4.00K | $73.40K | 4.00K |
| Jan 29, 14 | SPECTOR BRUCE H | CTO | Sale | -- | -- | -- | -- |
| Dec 23, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Sale | -- | 141.72K | -- | -- |
| Dec 23, 13 | Ashton Keith | President | Purchase | -- | 26 | -- | 276 |
| Dec 23, 13 | Brufsky Seth J | CEO | Purchase | -- | 5.86K | -- | 16.73K |
| Dec 23, 13 | Cascella Americo | President | Purchase | -- | 299 | -- | 299 |
| Dec 23, 13 | Schall Darryl | President | Purchase | -- | 65 | -- | 65 |
| Dec 23, 13 | SACHS DAVID A | CTO | Purchase | -- | 5.10K | -- | 5.10K |
| Dec 23, 13 | Nguyen Daniel F | CFO | Purchase | -- | 259 | -- | 259 |
| Dec 23, 13 | WEINER MICHAEL D | Officer | Purchase | -- | 480 | -- | 480 |
| Dec 23, 13 | RESSLER ANTONY P | CTO | Purchase | -- | 49.73K | -- | 49.73K |
| Dec 23, 13 | Margolies Gregory A | CTO | Purchase | -- | 5.34K | -- | 5.34K |
| Dec 23, 13 | Moore Jeff M | President | Purchase | -- | 498 | -- | 498 |
| Nov 15, 13 | Ashton Keith | President | Purchase | $17.84 | 250 | $4.46K | 250 |
| Oct 29, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.10 | 7.00K | $126.69K | 141.35K |
| Oct 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.06 | 7.50K | $135.42K | 134.35K |
| Oct 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.13 | 7.60K | $137.77K | 126.85K |
| Oct 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.13 | 6.07K | $109.99K | 119.25K |
| Oct 21, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.12 | 7.90K | $143.18K | 113.19K |
| Oct 21, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.06 | 5.80K | $104.73K | 105.29K |
| Oct 21, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.17 | 6.90K | $125.36K | 99.49K |
| Oct 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.15 | 7.50K | $136.12K | 92.59K |
| Oct 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.16 | 7.50K | $136.20K | 85.09K |
| Oct 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.01 | 7.50K | $135.09K | 77.59K |
| Sep 18, 13 | Moore Jeff M | Officer | Sale | -- | -- | -- | -- |
| Oct 10, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $17.95 | 7.50K | $134.61K | 70.09K |
| Oct 10, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.01 | 5.40K | $97.27K | 62.59K |
| Oct 10, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.02 | 7.50K | $135.14K | 57.19K |
| Oct 10, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.04 | 7.50K | $135.28K | 49.69K |
| Sep 18, 13 | Leupp John A. | Officer | Sale | -- | -- | -- | -- |
| Sep 18, 13 | Schall Darryl | Officer | Sale | -- | -- | -- | -- |
| Sep 27, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $17.94 | 4.70K | $84.33K | 42.19K |
| Sep 27, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.07 | 4.50K | $81.32K | 37.49K |
| Sep 27, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.11 | 500 | $9.05K | 32.99K |
| Sep 18, 13 | Eanes John | Officer | Sale | -- | -- | -- | -- |
| Sep 18, 13 | Cascella Americo | Officer | Sale | -- | -- | -- | -- |
| Oct 4, 13 | SACHS DAVID A | CTO | Purchase | $18.11 | 1.80K | $32.60K | 42.10K |
| Oct 2, 13 | Brufsky Seth J | CEO | Purchase | $18.44 | 1.00K | $18.44K | 10.50K |
| Sep 27, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $17.92 | 250 | $4.48K | 32.49K |
| Sep 27, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $17.99 | 2.80K | $50.43K | 32.24K |
| Sep 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $17.92 | 2.20K | $39.38K | 29.43K |
| Sep 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.18 | 1.10K | $20.03K | 27.24K |
| Sep 24, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.20 | 1.40K | $25.45K | 26.13K |
| Sep 19, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.31 | 4.00K | $73.25K | 24.74K |
| Sep 19, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.28 | 1.00K | $18.27K | 20.74K |
| Sep 19, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.59 | 3.00K | $55.76K | 19.74K |
| Sep 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.73 | 3.00K | $56.20K | 16.74K |
| Sep 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.35 | 1.00K | $18.35K | 13.74K |
| Sep 16, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.88 | 2.00K | $37.76K | 12.74K |
| Sep 12, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.78 | 5.00K | $93.90K | 10.74K |
| Sep 12, 13 | ARES CAPITAL MANAGEMENT II LLC | CTO | Purchase | $18.70 | 500 | $9.35K | 5.74K |
| Aug 21, 13 | SACHS DAVID A | CTO | Purchase | $18.15 | 300 | $5.45K | 40.30K |
| Aug 21, 13 | SACHS DAVID A | CTO | Purchase | $18.18 | 1.50K | $27.26K | 40.00K |
| Aug 19, 13 | SACHS DAVID A | CTO | Purchase | $18.30 | 1.50K | $27.45K | 38.50K |
| Jul 25, 13 | SACHS DAVID A | CTO | Purchase | $18.40 | 1.00K | $18.40K | 37.00K |
| Jun 19, 13 | SACHS DAVID A | CTO | Purchase | $18.95 | 3.00K | $56.84K | 36.00K |
| Jun 19, 13 | Brufsky Seth J | CEO | Purchase | $19.02 | 2.00K | $38.04K | 9.50K |
| Jun 10, 13 | SACHS DAVID A | CTO | Purchase | $19.46 | 5.00K | $97.30K | 33.00K |
| Mar 19, 13 | SACHS DAVID A | CTO | Purchase | $19.51 | 500 | $9.76K | 28.00K |
| Jan 16, 13 | Dell Anthony S | Officer | Purchase | $19.32 | 1.40K | $27.05K | 1.40K |
| Nov 27, 12 | ARES CAPITAL MANAGEMENT II LLC | CTO | Sale | -- | -- | -- | 5.24K |
| Nov 27, 12 | SACHS DAVID A | CTO | Purchase | $20.00 | 25.00K | $500.00K | 27.50K |
| Nov 27, 12 | SACHS DAVID A | CTO | Purchase | $20.00 | 2.50K | $50.00K | 2.50K |
| Nov 27, 12 | Erlanger Philip Robert | CTO | Purchase | $20.00 | 2.50K | $50.00K | 2.50K |
| Nov 27, 12 | Brufsky Seth J | CEO | Purchase | $20.00 | 7.50K | $150.00K | 7.50K |
| Nov 27, 12 | RESSLER ANTONY P | CTO | Purchase | $20.00 | 100.00K | $2.00M | 100.00K |
| Nov 27, 12 | RESSLER ANTONY P | CTO | Purchase | $20.00 | 17.00K | $340.00K | 21.40K |
| Nov 27, 12 | RESSLER ANTONY P | CTO | Purchase | $20.00 | 4.40K | $88.00K | 4.40K |
| Nov 27, 12 | RESSLER ANTONY P | CTO | Purchase | $20.00 | 4.30K | $86.00K | 4.30K |
| Nov 27, 12 | Margolies Gregory A | -- | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Ashton Keith | -- | Sale | -- | -- | -- | -- |
| Nov 27, 12 | WEINER MICHAEL D | Officer | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Shaw John Joseph | CTO | Sale | -- | -- | -- | -- |
| Nov 27, 12 | SACHS DAVID A | CTO | Sale | -- | -- | -- | -- |
| Nov 27, 12 | RESSLER ANTONY P | -- | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Parmar Hardip | Officer | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Nguyen Daniel F | Officer | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Hall Daniel J | Officer | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Erlanger Philip Robert | CTO | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Diamond Michael | CTO | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Dell Anthony S | Officer | Sale | -- | -- | -- | -- |
| Nov 27, 12 | Brufsky Seth J | CEO | Sale | -- | -- | -- | -- |
| Nov 27, 12 | ARES CAPITAL MANAGEMENT II LLC | CTO | Sale | -- | -- | -- | 5.24K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 35.67K | $98.44K | 83.11K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 2.53K | $6.98K | 47.44K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 3.32K | $9.16K | 44.91K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 6.00K | $16.56K | 41.59K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 9.14K | $25.22K | 35.59K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 5.01K | $13.84K | 26.45K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 8.33K | $23.00K | 21.44K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 1.04K | $2.88K | 13.11K |
| Dec 5, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 2.90K | $8.00K | 12.06K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 7.08K | $19.55K | 9.17K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Purchase | $2.76 | 2.08K | $5.75K | 2.08K |
| Dec 4, 07 | FUCHS HENRY J | CTO | Sale | $10.78 | 83.11K | $895.79K | -- |
| Dec 4, 07 | FUCHS HENRY J | CTO | Sale | $2.76 | 35.67K | $98.44K | -- |
| Jul 26, 07 | MANHARD KIMBERLY | Officer | Purchase | $5.95 | 30.00K | $178.50K | 30.00K |
| Jun 15, 07 | TANG KEVIN C | CTO | Purchase | $5.85 | 1.25K | $7.31K | 3.75K |
| Jun 15, 07 | TANG KEVIN C | CTO | Purchase | $5.85 | 2.50K | $14.63K | 2.50K |
| Jun 15, 07 | POYHONEN JOHN | CTO | Sale | -- | -- | -- | -- |
| Jun 15, 07 | POYHONEN JOHN | CTO | Purchase | $5.85 | 25.00K | $146.25K | 25.00K |
| Jun 15, 07 | POYHONEN JOHN | CTO | Purchase | $5.85 | 2.50K | $14.63K | 2.50K |
| Jun 11, 07 | TANG KEVIN C | CTO | Purchase | $1.03 | 426.15K | $440.22K | 2.14M |
| Jun 11, 07 | TANG KEVIN C | CTO | Sale | $1.03 | 426.15K | $440.22K | -- |
| Jun 11, 07 | Baker / Tisch Capital (GP), LLC | 10 percent owner | Purchase | $1.03 | 21.04K | $21.74K | 37.12K |
| Jun 11, 07 | Baker / Tisch Capital (GP), LLC | 10 percent owner | Sale | $1.03 | 21.04K | $21.74K | -- |
| Jun 11, 07 | Baker Bros. Capital (GP), LLC | 10 percent owner | Purchase | $1.03 | 28.94K | $29.89K | 133.06K |
| Jun 11, 07 | Baker Bros. Capital (GP), LLC | 10 percent owner | Sale | $1.03 | 28.94K | $29.89K | -- |
| Jun 11, 07 | Baker Biotech Capital (GP), LLC | 10 percent owner | Purchase | $1.03 | 147.31K | $152.17K | 777.51K |
| Jun 11, 07 | Baker Biotech Capital (GP), LLC | 10 percent owner | Sale | $1.03 | 147.31K | $152.17K | -- |
| Jun 11, 07 | Baker Brothers Life Sciences Capital (GP), LLC | 10 percent owner | Purchase | $1.03 | 165.73K | $171.20K | 1.17M |
| Jun 11, 07 | Baker Brothers Life Sciences Capital (GP), LLC | 10 percent owner | Sale | $1.03 | 165.73K | $171.20K | -- |
