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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Aug 12, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.85 | 41.28K | $117.66K | -- |
| Aug 12, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $4.00 | 273.03K | $1.09M | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | $3.19 | 1.25K | $3.99K | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | $4.00 | 92.62K | $370.49K | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | $2.70 | 2.50K | $6.75K | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | $4.83 | 1.25K | $6.04K | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | -- | 11.39K | -- | -- |
| Aug 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | $3.60 | 5.25K | $18.90K | -- |
| Aug 12, 10 | DALE MICHAEL D | CEO | Sale | $4.00 | 275.87K | $1.10M | -- |
| Aug 12, 10 | DALE MICHAEL D | CEO | Sale | $3.80 | 50.00K | $190.00K | -- |
| Aug 12, 10 | DALE MICHAEL D | CEO | Sale | $0.37 | 300.00K | $111.00K | -- |
| Aug 12, 10 | DALE MICHAEL D | CEO | Sale | -- | 400.00K | -- | -- |
| Aug 12, 10 | DALE MICHAEL D | CEO | Sale | -- | 500.00K | -- | -- |
| Jul 30, 10 | DALE MICHAEL D | CEO | Purchase | -- | 40.00K | -- | 290.45K |
| Jul 30, 10 | DALE MICHAEL D | CEO | Sale | $4.00 | 14.58K | $58.32K | 275.87K |
| Jul 30, 10 | DALE MICHAEL D | CEO | Sale | -- | 40.00K | -- | 120.00K |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.85 | 90.63K | $258.28K | 8.71M |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.48 | 906.25K | $2.24M | 8.62M |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.48 | 906.25K | $2.24M | 1.41M |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.85 | 90.63K | $258.28K | 1.32M |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.85 | 6.53K | $18.62K | 627.97K |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.48 | 65.34K | $161.72K | 621.43K |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.85 | 2.84K | $8.10K | 273.03K |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Purchase | $2.48 | 28.41K | $70.31K | 270.19K |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.48 | 65.34K | $161.72K | 101.49K |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.85 | 6.53K | $18.62K | 94.95K |
| Dec 18, 09 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.48 | 28.41K | $70.31K | 44.13K |
| Jun 3, 10 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | $2.85 | 2.84K | $8.10K | 41.28K |
| Dec 19, 08 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | -- | -- | -- | 7.71M |
| Dec 19, 08 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | -- | -- | -- | 556.09K |
| Dec 19, 08 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | -- | -- | -- | 241.78K |
| Dec 19, 08 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | -- | 72.53K | -- | -- |
| Dec 19, 08 | ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP | 10 percent owner | Sale | -- | 2.31M | -- | -- |
| May 12, 10 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 21.33K | -- | 92.62K |
| May 12, 10 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 11.39K | -- | 11.39K |
| May 12, 10 | MUNZENRIDER ROBERT E | CTO | Sale | -- | 21.33K | -- | -- |
| Mar 15, 10 | DALE MICHAEL D | CEO | Sale | -- | 100.00K | -- | 400.00K |
| Mar 15, 10 | DALE MICHAEL D | CEO | Purchase | -- | 192.56K | -- | 339.75K |
| Mar 15, 10 | DALE MICHAEL D | CEO | Sale | $2.51 | 70.00K | $175.82K | 269.75K |
| Mar 16, 10 | DALE MICHAEL D | CEO | Sale | $2.50 | 19.30K | $48.28K | 250.45K |
| Mar 15, 10 | DALE MICHAEL D | CEO | Sale | -- | 60.00K | -- | 180.00K |
| Mar 15, 10 | DALE MICHAEL D | CEO | Sale | -- | 32.56K | -- | 65.08K |
| Nov 9, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.90 | 10.25K | $29.73K | 71.83K |
| Nov 6, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.90 | 5.03K | $14.59K | 83.45K |
| Nov 6, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.95 | 1.37K | $4.04K | 82.08K |
| Feb 16, 10 | DALE MICHAEL D | CEO | Purchase | -- | 500.00K | -- | 500.00K |
| Jan 11, 10 | DALE MICHAEL D | CEO | Purchase | -- | 8.00K | -- | 151.39K |
| Jan 11, 10 | DALE MICHAEL D | CEO | Sale | $3.27 | 1.20K | $3.92K | 150.19K |
| Jan 11, 10 | DALE MICHAEL D | CEO | Sale | $3.26 | 3.00K | $9.78K | 147.19K |
| Jan 11, 10 | DALE MICHAEL D | CEO | Sale | -- | 8.00K | -- | 8.00K |
| Nov 16, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.95 | 533 | $1.57K | 77.69K |
| Nov 11, 09 | DALE MICHAEL D | CEO | Sale | $2.85 | 25.00K | $71.25K | 143.39K |
| Nov 6, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.90 | 10.25K | $29.73K | 78.23K |
| Nov 5, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.90 | 8.10K | $23.49K | 93.98K |
| Nov 5, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.91 | 1.90K | $5.53K | 92.08K |
| Nov 5, 09 | MUNZENRIDER ROBERT E | CTO | Sale | $2.95 | 3.60K | $10.62K | 88.48K |
| Oct 12, 09 | DALE MICHAEL D | CEO | Sale | $2.76 | 25.00K | $68.95K | 168.39K |
| Sep 10, 08 | DALE MICHAEL D | CEO | Sale | $2.66 | 25.00K | $66.39K | 193.39K |
| Aug 10, 08 | DALE MICHAEL D | CEO | Sale | $3.00 | 25.00K | $75.03K | 218.39K |
| Jul 30, 09 | DALE MICHAEL D | CEO | Purchase | -- | 40.00K | -- | 261.89K |
| Jul 31, 08 | DALE MICHAEL D | CEO | Sale | $3.45 | 15.00K | $51.75K | 246.89K |
| Jul 31, 08 | DALE MICHAEL D | CEO | Sale | $3.48 | 3.50K | $12.18K | 243.39K |
| Jul 30, 09 | DALE MICHAEL D | CEO | Sale | -- | 40.00K | -- | 160.00K |
| Jul 10, 09 | DALE MICHAEL D | CEO | Sale | $3.10 | 25.00K | $77.56K | 221.89K |
| Jun 10, 09 | DALE MICHAEL D | CEO | Sale | $2.98 | 1.60K | $4.77K | 270.29K |
| Jun 11, 09 | DALE MICHAEL D | CEO | Sale | $2.90 | 23.40K | $67.94K | 246.89K |
| May 11, 09 | DALE MICHAEL D | CEO | Sale | $2.79 | 32.00K | $89.39K | 289.89K |
| May 12, 09 | DALE MICHAEL D | CEO | Sale | $2.78 | 18.00K | $50.02K | 271.89K |
| May 7, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 28.66K | -- | 105.01K |
| May 7, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 15.90K | -- | 15.90K |
| May 7, 09 | MUNZENRIDER ROBERT E | CTO | Sale | -- | 28.66K | -- | -- |
| Mar 15, 09 | DALE MICHAEL D | CEO | Purchase | -- | 92.56K | -- | 368.49K |
| Mar 16, 09 | DALE MICHAEL D | CEO | Sale | $2.16 | 16.90K | $36.58K | 351.59K |
| Mar 17, 09 | DALE MICHAEL D | CEO | Sale | $2.10 | 29.70K | $62.47K | 321.89K |
| Mar 15, 09 | DALE MICHAEL D | CEO | Sale | -- | 60.00K | -- | 240.00K |
| Mar 15, 09 | DALE MICHAEL D | CEO | Sale | -- | 32.60K | -- | 97.63K |
| Feb 26, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.30 | 100 | $230 | 76.35K |
| Feb 26, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.31 | 400 | $924 | 76.25K |
| Feb 26, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.32 | 18.30K | $42.44K | 75.85K |
| Feb 26, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.33 | 12.21K | $28.44K | 57.56K |
| Feb 26, 09 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.34 | 12.20K | $28.55K | 45.35K |
| Feb 18, 09 | DALE MICHAEL D | CEO | Purchase | -- | 500.00K | -- | 500.00K |
| Jan 10, 09 | DALE MICHAEL D | CEO | Purchase | -- | 8.00K | -- | 280.16K |
| Jan 12, 09 | DALE MICHAEL D | CEO | Sale | $2.79 | 4.22K | $11.77K | 275.94K |
| Jan 10, 09 | DALE MICHAEL D | CEO | Sale | -- | 8.00K | -- | 16.00K |
| Jul 30, 08 | DALE MICHAEL D | CEO | Purchase | -- | 200.00K | -- | 200.00K |
| Jun 26, 08 | Alta Partners VIII, L.P. | 10 percent owner | Purchase | $1.65 | 1.96M | $3.23M | 11.76M |
| Jun 26, 08 | Alta Partners VIII, L.P. | 10 percent owner | Sale | $1.65 | 1.96M | $3.23M | -- |
| Jun 26, 08 | Alta Partners VIII, L.P. | 10 percent owner | Purchase | $1.65 | 1.96M | $3.23M | 11.76M |
| Jun 26, 08 | Alta Partners VIII, L.P. | 10 percent owner | Sale | $1.65 | 1.96M | $3.23M | -- |
| May 9, 08 | MUNZENRIDER ROBERT E | CTO | Purchase | $2.11 | 9.40K | $19.83K | 33.15K |
| May 8, 08 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 18.75K | -- | 23.75K |
| May 8, 08 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 21.33K | -- | 21.33K |
| May 8, 08 | MUNZENRIDER ROBERT E | CTO | Sale | -- | 18.75K | -- | -- |
| Mar 18, 08 | DALE MICHAEL D | CEO | Sale | $1.45 | 9.96K | $14.45K | 273.16K |
| Mar 18, 08 | DALE MICHAEL D | CEO | Sale | $1.46 | 100 | $146 | 273.06K |
| Mar 18, 08 | DALE MICHAEL D | CEO | Sale | $1.47 | 900 | $1.32K | 272.16K |
| Mar 14, 08 | DALE MICHAEL D | CEO | Purchase | -- | 32.56K | -- | 283.12K |
| Feb 18, 08 | DALE MICHAEL D | Officer | Sale | -- | -- | -- | -- |
| Mar 17, 08 | DALE MICHAEL D | CEO | Sale | $1.45 | 10.96K | $15.90K | 272.16K |
| Mar 14, 08 | DALE MICHAEL D | CEO | Sale | -- | 32.56K | -- | 130.23K |
| Feb 18, 08 | DALE MICHAEL D | CEO | Purchase | -- | 300.00K | -- | 300.00K |
| Jan 10, 08 | DALE MICHAEL D | CEO | Purchase | -- | 58.00K | -- | 274.71K |
| Jan 11, 08 | DALE MICHAEL D | CEO | Sale | $1.99 | 21.22K | $42.28K | 253.49K |
| Jan 11, 08 | DALE MICHAEL D | CEO | Sale | $2.00 | 2.93K | $5.85K | 250.56K |
| Jan 10, 08 | DALE MICHAEL D | CEO | Sale | -- | 8.00K | -- | 24.00K |
| Jan 10, 08 | DALE MICHAEL D | CEO | Sale | -- | 50.00K | -- | -- |
| Dec 7, 07 | MUNZENRIDER ROBERT E | CTO | Purchase | $1.92 | 650 | $1.25K | 5.00K |
| Dec 7, 07 | MUNZENRIDER ROBERT E | CTO | Purchase | $1.93 | 4.35K | $8.40K | 4.35K |
| Jun 28, 07 | Alta Partners VIII, L.P. | 10 percent owner | Sale | -- | -- | -- | 9.80M |
| Jun 28, 08 | Alta Partners VIII, L.P. | 10 percent owner | Sale | $1.65 | 1.96M | $3.23M | -- |
| May 22, 07 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 28.66K | -- | 28.66K |
| May 22, 07 | DALE MICHAEL D | CEO | Purchase | -- | 162.79K | -- | 162.79K |
| Mar 1, 07 | DALE MICHAEL D | CEO | Purchase | -- | 50.00K | -- | 233.09K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.31 | 1.00K | $2.31K | 232.09K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.33 | 1.00K | $2.33K | 231.09K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.35 | 1.00K | $2.35K | 230.09K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.37 | 8.15K | $19.32K | 221.94K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.37 | 30 | $71.103 | 221.91K |
| Mar 2, 07 | DALE MICHAEL D | CEO | Sale | $2.38 | 5.20K | $12.38K | 216.71K |
| Mar 1, 07 | DALE MICHAEL D | CEO | Sale | -- | 50.00K | -- | 50.00K |
| Jan 10, 07 | DALE MICHAEL D | CEO | Purchase | -- | 58.00K | -- | 205.90K |
| Jan 11, 07 | DALE MICHAEL D | CEO | Sale | $2.18 | 100 | $218 | 205.80K |
| Jan 11, 07 | DALE MICHAEL D | CEO | Sale | $2.17 | 100 | $217 | 205.70K |
| Jan 11, 07 | DALE MICHAEL D | CEO | Sale | $2.16 | 200 | $432 | 205.50K |
| Jan 11, 07 | DALE MICHAEL D | CEO | Sale | $2.15 | 20.95K | $45.04K | 184.55K |
| Jan 11, 07 | DALE MICHAEL D | CEO | Sale | $2.13 | 1.47K | $3.12K | 183.09K |
| Jan 10, 07 | DALE MICHAEL D | CEO | Sale | -- | 50.00K | -- | 100.00K |
| Jan 10, 07 | DALE MICHAEL D | CEO | Sale | -- | 8.00K | -- | 32.00K |
| Sep 25, 06 | MUNZENRIDER ROBERT E | CTO | Purchase | -- | 18.75K | -- | 18.75K |
| May 1, 06 | DALE MICHAEL D | CEO | Purchase | -- | 40.00K | -- | 40.00K |
| Jan 10, 06 | JUDD JOHN R | CFO | Sale | -- | 12.50K | -- | 37.50K |
| Jan 10, 06 | JUDD JOHN R | CFO | Sale | $2.91 | 4.86K | $14.15K | 22.19K |
| Jan 10, 06 | JUDD JOHN R | CFO | Purchase | -- | 12.50K | -- | 14.55K |
| Jan 10, 06 | DALE MICHAEL D | CEO | Purchase | -- | 50.00K | -- | 165.97K |
| Jan 10, 06 | DALE MICHAEL D | CEO | Sale | -- | 50.00K | -- | 150.00K |
| Jan 10, 06 | DALE MICHAEL D | CEO | Sale | $2.91 | 18.07K | $52.59K | 147.90K |
| May 5, 05 | Buck John D | CTO | Purchase | $3.19 | 2.50K | $7.97K | 2.50K |
| May 5, 05 | MUNZENRIDER ROBERT E | CTO | Purchase | $3.19 | 2.50K | $7.97K | 2.50K |
| May 5, 05 | BOEHNEN DAVID L | CTO | Purchase | $3.19 | 2.50K | $7.97K | 2.50K |
| May 5, 05 | DALE MICHAEL D | CEO | Purchase | -- | 200.00K | -- | 200.00K |
| May 5, 05 | JUDD JOHN R | CFO | Purchase | -- | 50.00K | -- | 50.00K |
| Nov 12, 04 | Buck John D | CTO | Purchase | $4.20 | 100 | $420 | 10.00K |
| Nov 12, 04 | Buck John D | CTO | Purchase | $4.22 | 1.00K | $4.22K | 9.90K |
| Nov 12, 04 | Buck John D | CTO | Purchase | $4.23 | 100 | $423 | 8.90K |
| Nov 12, 04 | Buck John D | CTO | Purchase | $4.24 | 8.80K | $37.31K | 8.80K |
| Nov 2, 04 | Buck John D | CTO | Purchase | $3.60 | 15.00K | $54.00K | 15.00K |
| Nov 2, 04 | Buck John D | CTO | Purchase | $3.60 | 5.00K | $18.00K | 5.00K |
| Nov 2, 04 | MUNZENRIDER ROBERT E | CTO | Purchase | $3.60 | 7.50K | $27.00K | 7.50K |
| Nov 2, 04 | BOEHNEN DAVID L | CTO | Purchase | $3.60 | 7.50K | $27.00K | 7.50K |
| Sep 13, 04 | Buck John D | CTO | Sale | -- | -- | -- | -- |
| Feb 25, 04 | BOEHNEN DAVID L | CTO | Sale | -- | 10.00K | -- | 64.76K |
| May 6, 04 | BOEHNEN DAVID L | CTO | Purchase | $4.83 | 2.50K | $12.07K | 2.50K |
| Feb 2, 04 | BOEHNEN DAVID L | CTO | Sale | -- | 3.00K | -- | -- |
| May 7, 04 | JUDD JOHN R | CFO | Purchase | $4.90 | 3.85K | $18.86K | 5.99K |
| May 7, 04 | JUDD JOHN R | CFO | Purchase | $4.89 | 1.15K | $5.62K | 2.14K |
| May 6, 04 | MUNZENRIDER ROBERT E | CTO | Purchase | $4.83 | 2.50K | $12.07K | 2.50K |
| Apr 7, 04 | DALE MICHAEL D | CEO | Sale | $0.37 | 100.00K | $37.00K | 300.00K |
| Apr 7, 04 | DALE MICHAEL D | CEO | Purchase | $0.37 | 100.00K | $37.00K | 114.30K |
| Dec 19, 03 | DALE MICHAEL D | Officer | Purchase | $3.80 | 50.00K | $190.00K | 50.00K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.46 | 400 | $1.38K | 12.47K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.45 | 300 | $1.03K | 9.60K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.45 | 200 | $689.8 | 9.30K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.44 | 200 | $688 | 9.10K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.43 | 600 | $2.06K | 8.90K |
| Nov 21, 03 | DALE MICHAEL D | CEO | Sale | $3.42 | 3.30K | $11.29K | 8.30K |
| Oct 7, 04 | JUDD JOHN R | CFO | Sale | $3.76 | 125.00K | $470.00K | -- |
