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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Feb 24, 23 | 5AM Partners VI, LLC | 10 percent owner | Sale | $26.00 | 496.32K | $12.90M | -- |
| Feb 24, 23 | HEALY JAMES | CTO | Sale | $26.00 | 9.80K | $254.88K | 19.61K |
| Feb 24, 23 | HEALY JAMES | CTO | Sale | -- | 19.61K | -- | -- |
| Nov 28, 22 | HEALY JAMES | CTO | Sale | $14.32 | 6.00K | $85.92K | -- |
| Feb 24, 23 | HEALY JAMES | CTO | Sale | $26.00 | 6.07M | $157.92M | -- |
| Feb 24, 23 | Freeman Mason | Officer | Sale | $26.00 | 2.49K | $64.84K | 40.00K |
| Jun 10, 22 | Freeman Mason | Officer | Sale | $15.21 | 6 | $91.26 | 2.49K |
| Feb 24, 23 | Freeman Mason | Officer | Sale | $26.00 | 100 | $2.60K | -- |
| Feb 24, 23 | Freeman Mason | Officer | Sale | -- | 40.00K | -- | -- |
| Feb 24, 23 | Freeman Mason | Officer | Sale | $0.92 | 30.18K | $27.76K | -- |
| Feb 24, 23 | Freeman Mason | Officer | Sale | $7.62 | 120.38K | $917.30K | -- |
| Feb 24, 23 | Freeman Mason | Officer | Sale | $5.82 | 145.30K | $845.62K | -- |
| Feb 24, 23 | Allison David D. | CTO | Sale | $19.55 | 1.04K | $20.29K | -- |
| Feb 24, 23 | Allison David D. | CTO | Sale | $11.78 | 1.50K | $17.66K | -- |
| Feb 24, 23 | Allison David D. | CTO | Sale | $33.49 | 524 | $17.55K | -- |
| Feb 24, 23 | Allison David D. | CTO | Sale | $20.20 | 881 | $17.80K | -- |
| Feb 24, 23 | Allison David D. | CTO | Sale | $13.60 | 29.41K | $399.99K | -- |
| Feb 24, 23 | Ignelzi Troy A. | CTO | Sale | $13.60 | 58.82K | $799.99K | -- |
| Feb 24, 23 | Ignelzi Troy A. | CTO | Sale | $5.82 | 36.32K | $211.41K | -- |
| Feb 24, 23 | Kalb Michael Wayne | CFO | Sale | $30.07 | 77.61K | $2.33M | -- |
| Feb 24, 23 | Kalb Michael Wayne | CFO | Sale | $26.00 | 202.44K | $5.26M | -- |
| Feb 24, 23 | Lee June | CTO | Sale | $16.00 | 47.95K | $767.26K | -- |
| Feb 24, 23 | Pearce Catherine | COO | Sale | $26.00 | 140.15K | $3.64M | 15.00K |
| Feb 24, 23 | Pearce Catherine | COO | Sale | $26.00 | 1.50K | $39.00K | -- |
| Feb 24, 23 | Pearce Catherine | COO | Sale | -- | 15.00K | -- | -- |
| Feb 24, 23 | Pearce Catherine | COO | Sale | -- | 13.24K | -- | -- |
| Feb 24, 23 | Pearce Catherine | COO | Sale | $2.55 | 110.14K | $280.85K | -- |
| Feb 24, 23 | THERO JOHN F | CTO | Sale | $5.82 | 36.32K | $211.41K | -- |
| Feb 24, 23 | THERO JOHN F | CTO | Sale | $13.60 | 58.82K | $799.99K | -- |
| Feb 24, 23 | de Garidel Marc | CEO | Sale | $26.00 | 12.50K | $325.00K | 200.00K |
| Feb 24, 23 | de Garidel Marc | CEO | Sale | $5.82 | 726.48K | $4.23M | -- |
| Feb 24, 23 | de Garidel Marc | CEO | Sale | -- | 200.00K | -- | -- |
| Feb 24, 23 | de Garidel Marc | CEO | Sale | $7.62 | 601.90K | $4.59M | -- |
| Jan 26, 23 | de Garidel Marc | CEO | Purchase | -- | 200.00K | -- | 212.50K |
| Jan 26, 23 | Pearce Catherine | COO | Purchase | -- | 15.00K | -- | 155.15K |
| Jan 26, 23 | Kalb Michael Wayne | CFO | Purchase | -- | 177.00K | -- | 202.44K |
| Jan 26, 23 | Freeman Mason | Officer | Purchase | -- | 40.00K | -- | 42.50K |
| Jan 11, 23 | Pearce Catherine | COO | Purchase | -- | 13.23K | -- | 144.15K |
| Jan 11, 23 | Pearce Catherine | COO | Sale | $28.75 | 4.00K | $114.91K | 140.15K |
| Jan 11, 23 | Pearce Catherine | COO | Sale | -- | 13.23K | -- | 13.24K |
| Jan 6, 23 | Allison David D. | CTO | Purchase | $8.34 | 1.50K | $12.50K | 1.50K |
| Nov 4, 22 | Kalb Michael Wayne | CFO | Purchase | -- | 77.61K | -- | 77.61K |
| Nov 4, 22 | Kalb Michael Wayne | CFO | Purchase | -- | 25.44K | -- | 25.44K |
| Nov 4, 22 | Kalb Michael Wayne | Officer | Sale | -- | -- | -- | -- |
| Nov 4, 22 | Kalb Michael Wayne | -- | Sale | -- | -- | -- | -- |
| Oct 7, 22 | Allison David D. | CTO | Purchase | $23.85 | 524 | $12.50K | 524 |
| Aug 15, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | $30.00 | 112.67K | $3.38M | 3.95M |
| Aug 15, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | $30.00 | 487.33K | $14.62M | 487.33K |
| Aug 15, 22 | 5AM Opportunities II, L.P. | CTO | Purchase | $30.00 | 487.33K | $14.62M | 487.33K |
| Aug 15, 22 | Sofinnova Capital IX | CTO | Purchase | $30.00 | 133.33K | $4.00M | 4.22M |
| Aug 15, 22 | Sofinnova Partners SAS | 10 percent owner | Purchase | $30.00 | 133.33K | $4.00M | 4.22M |
| Aug 11, 22 | Katabi Maha | CTO | Purchase | $30.00 | 500.00K | $15.00M | 6.07M |
| Aug 11, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Purchase | $30.00 | 500.00K | $15.00M | 6.07M |
| Aug 11, 22 | HEALY JAMES | CTO | Purchase | $30.00 | 500.00K | $15.00M | 6.07M |
| Aug 11, 22 | HEALY JAMES | CTO | Purchase | $30.00 | 6.00K | $180.00K | 6.00K |
| Aug 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | 10 percent owner | Purchase | $30.00 | 83.00K | $2.49M | 4.21M |
| Aug 11, 22 | General Atlantic (SPV) GP, LLC | CTO | Purchase | $30.00 | 83.00K | $2.49M | 4.21M |
| Aug 11, 22 | GENERAL ATLANTIC, L.P. | 10 percent owner | Purchase | $30.00 | 83.00K | $2.49M | 4.21M |
| Aug 11, 22 | General Atlantic GenPar (Lux) SCSp | CTO | Purchase | $30.00 | 83.00K | $2.49M | 4.21M |
| Aug 5, 22 | HEALY JAMES | CTO | Purchase | $13.60 | 29.41K | $399.99K | 29.41K |
| Aug 5, 22 | HEALY JAMES | CTO | Sale | -- | 29.41K | -- | -- |
| Aug 5, 22 | HEALY JAMES | CTO | Sale | $13.60 | 29.41K | $399.99K | -- |
| Jul 8, 22 | Allison David D. | CTO | Purchase | $14.19 | 881 | $12.50K | 881 |
| Apr 8, 22 | Allison David D. | CTO | Purchase | $19.55 | 1.04K | $20.29K | 1.04K |
| Apr 8, 22 | Allison David D. | CTO | Purchase | -- | 1.04K | -- | 1.04K |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | 10 percent owner | Purchase | $16.00 | 1.70M | $27.20M | 4.13M |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | CTO | Purchase | $16.00 | 1.70M | $27.20M | 4.13M |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | CTO | Purchase | -- | 2.43M | -- | 2.43M |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | 10 percent owner | Purchase | -- | 2.43M | -- | 2.43M |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | CTO | Sale | -- | 8.25M | -- | -- |
| Jan 11, 22 | GENERAL ATLANTIC GENPAR (BERMUDA), L.P. | 10 percent owner | Sale | -- | 8.25M | -- | -- |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | CTO | Purchase | $16.00 | 1.70M | $27.20M | 4.13M |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | 10 percent owner | Purchase | $16.00 | 1.70M | $27.20M | 4.13M |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | 10 percent owner | Purchase | -- | 2.43M | -- | 2.43M |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | CTO | Purchase | -- | 2.43M | -- | 2.43M |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | 10 percent owner | Sale | -- | 8.25M | -- | -- |
| Jan 11, 22 | GENERAL ATLANTIC, L.P. | CTO | Sale | -- | 8.25M | -- | -- |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | $16.00 | 157.50K | $2.52M | 3.84M |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Purchase | $16.00 | 157.50K | $2.52M | 3.84M |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | -- | 3.68M | -- | 3.68M |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Purchase | -- | 3.68M | -- | 3.68M |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | $16.00 | 312.50K | $5.00M | 496.32K |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Purchase | $16.00 | 312.50K | $5.00M | 496.32K |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Purchase | -- | 183.82K | -- | 183.82K |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Purchase | -- | 183.82K | -- | 183.82K |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Sale | -- | 625.00K | -- | -- |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Sale | -- | 10.00M | -- | -- |
| Jan 11, 22 | 5AM Partners VI, LLC | CTO | Sale | -- | 10.00M | -- | -- |
| Jan 11, 22 | 5AM Partners VI, LLC | 10 percent owner | Sale | -- | 625.00K | -- | -- |
| Jan 11, 22 | CinRx Pharma, LLC | 10 percent owner | Purchase | -- | 1.22M | -- | 3.63M |
| Jan 11, 22 | CinRx Pharma, LLC | 10 percent owner | Sale | -- | 2.01M | -- | -- |
| Jan 11, 22 | CinRx Pharma, LLC | 10 percent owner | Sale | -- | 2.14M | -- | -- |
| Jan 11, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Purchase | $16.00 | 325.00K | $5.20M | 5.57M |
| Jan 11, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Purchase | -- | 5.25M | -- | 5.25M |
| Jan 11, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Sale | -- | 13.57M | -- | -- |
| Jan 11, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Sale | -- | 4.28M | -- | -- |
| Jan 11, 22 | Sofinnova Partners SAS | 10 percent owner | Purchase | $16.00 | 220.00K | $3.52M | 4.09M |
| Jan 11, 22 | Sofinnova Partners SAS | 10 percent owner | Purchase | -- | 3.87M | -- | 3.87M |
| Jan 11, 22 | Sofinnova Partners SAS | 10 percent owner | Sale | -- | 10.00M | -- | -- |
| Jan 11, 22 | Sofinnova Partners SAS | 10 percent owner | Sale | -- | 3.15M | -- | -- |
| Jan 11, 22 | HEALY JAMES | CTO | Purchase | $16.00 | 325.00K | $5.20M | 5.57M |
| Jan 11, 22 | HEALY JAMES | CTO | Purchase | -- | 5.25M | -- | 5.25M |
| Jan 11, 22 | HEALY JAMES | CTO | Sale | -- | 4.28M | -- | -- |
| Jan 11, 22 | HEALY JAMES | CTO | Sale | -- | 13.57M | -- | -- |
| Jan 11, 22 | Pearce Catherine | COO | Purchase | $16.00 | 750 | $12.00K | 130.91K |
| Jan 11, 22 | Pearce Catherine | COO | Purchase | $16.00 | 1.50K | $24.00K | 1.50K |
| Jan 11, 22 | Freeman Mason | Officer | Purchase | $16.00 | 2.50K | $40.00K | 2.50K |
| Jan 11, 22 | Freeman Mason | Officer | Purchase | $16.00 | 100 | $1.60K | 100 |
| Jan 11, 22 | de Garidel Marc | CEO | Purchase | $16.00 | 12.50K | $200.00K | 12.50K |
| Jan 11, 22 | Coelho Mary Theresa | CFO | Purchase | $16.00 | 100 | $1.60K | 100 |
| Jan 11, 22 | Coelho Mary Theresa | CFO | Purchase | $16.00 | 100 | $1.60K | 100 |
| Jan 12, 22 | Pearce Catherine | COO | Purchase | -- | 26.47K | -- | 26.47K |
| Jan 6, 22 | Pearce Catherine | COO | Purchase | -- | 26.47K | -- | 26.47K |
| Jan 6, 22 | Lee June | CTO | Purchase | $16.00 | 47.95K | $767.26K | 47.95K |
| Jan 6, 22 | CinRx Pharma, LLC | 10 percent owner | Sale | -- | -- | -- | 2.41M |
| Jan 6, 22 | CinRx Pharma, LLC | 10 percent owner | Sale | -- | 630.25K | -- | -- |
| Jan 6, 22 | CinRx Pharma, LLC | 10 percent owner | Sale | -- | 592.28K | -- | -- |
| Jan 6, 22 | General Atlantic (CIN), L.P. | 10 percent owner | Sale | -- | 2.43M | -- | -- |
| Jan 6, 22 | General Atlantic (CIN), L.P. | 10 percent owner | Sale | -- | 2.43M | -- | -- |
| Jan 6, 22 | GENERAL ATLANTIC, L.P. | 10 percent owner | Sale | -- | 2.43M | -- | -- |
| Jan 6, 22 | 5AM Partners VI, LLC | 10 percent owner | Sale | -- | 2.94M | -- | -- |
| Jan 6, 22 | 5AM Partners VI, LLC | 10 percent owner | Sale | -- | 183.82K | -- | -- |
| Jan 6, 22 | THERO JOHN F | CTO | Sale | $5.82 | 36.32K | $211.41K | -- |
| Jan 6, 22 | THERO JOHN F | CTO | Sale | $13.60 | 58.82K | $799.99K | -- |
| Jan 6, 22 | Pitts Jason | CTO | Sale | -- | -- | -- | -- |
| Jan 6, 22 | Lee June | CTO | Sale | -- | -- | -- | -- |
| Jan 6, 22 | Ignelzi Troy A. | CTO | Sale | $5.82 | 36.32K | $211.41K | -- |
| Jan 6, 22 | Ignelzi Troy A. | CTO | Sale | $13.60 | 58.82K | $799.99K | -- |
| Jan 6, 22 | Sofinnova Partners SAS | 10 percent owner | Sale | -- | 2.94M | -- | -- |
| Jan 6, 22 | Sofinnova Partners SAS | 10 percent owner | Sale | -- | 926.47K | -- | -- |
| Jan 6, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Sale | -- | 1.26M | -- | -- |
| Jan 6, 22 | Sofinnova Venture Partners X, L.P. | 10 percent owner | Sale | -- | 3.99M | -- | -- |
| Jan 6, 22 | HEALY JAMES | CTO | Sale | -- | 3.99M | -- | -- |
| Jan 6, 22 | HEALY JAMES | CTO | Sale | $13.60 | 29.41K | $399.99K | -- |
| Jan 6, 22 | HEALY JAMES | CTO | Sale | -- | 1.26M | -- | -- |
| Jan 6, 22 | Bhaman Maina | CTO | Sale | -- | -- | -- | -- |
| Jan 6, 22 | Allison David D. | CTO | Sale | $13.60 | 29.41K | $399.99K | -- |
| Jan 6, 22 | Freeman Mason | Officer | Sale | $5.82 | 145.30K | $845.62K | -- |
| Jan 6, 22 | Freeman Mason | Officer | Sale | $0.92 | 30.18K | $27.76K | -- |
| Jan 6, 22 | Freeman Mason | Officer | Sale | $7.62 | 120.38K | $917.30K | -- |
| Jan 6, 22 | Pearce Catherine | COO | Sale | -- | -- | -- | 130.16K |
| Jan 6, 22 | Pearce Catherine | COO | Sale | $2.55 | 110.14K | $280.85K | -- |
| Jan 6, 22 | Coelho Mary Theresa | CFO | Sale | $7.62 | 332.10K | $2.53M | -- |
| Jan 6, 22 | de Garidel Marc | CEO | Sale | $5.82 | 726.48K | $4.23M | -- |
| Jan 6, 22 | de Garidel Marc | CEO | Sale | $7.62 | 601.90K | $4.59M | -- |
