| Sep 4, 12 | ARNONE JOHN S | CEO | Purchase | $0.15 | 800.00K | $120.00K | 800.00K |
| Sep 4, 12 | Dudzinski Anthony Francis | COO | Purchase | $0.15 | 580.00K | $87.00K | 580.00K |
| Apr 21, 11 | ARNONE JOHN S | CTO | Sale | -- | -- | -- | 21.00M |
| Apr 21, 11 | Dudzinski Anthony Francis | COO | Sale | -- | -- | -- | 21.00M |
| Apr 21, 11 | Neill Christopher Joseph | 10 percent owner | Sale | -- | -- | -- | 3.45M |
| Apr 21, 11 | ACS Global, Inc. | 10 percent owner | Sale | -- | -- | -- | 21.00M |
| Apr 21, 11 | ACS Global, Inc. | 10 percent owner | Sale | -- | -- | -- | 21.00M |
| Apr 23, 10 | Medina Hector | CTO | Sale | -- | -- | -- | 2.50M |
| May 28, 08 | William Blair Capital Management VII, LLC | 10 percent owner | Sale | $2.35 | 6.45K | $15.16K | -- |
| May 28, 08 | William Blair Capital Management VII, LLC | 10 percent owner | Sale | $1.35 | 1.94M | $2.63M | -- |
| May 28, 08 | William Blair Capital Management VII, LLC | 10 percent owner | Sale | $6.69 | 6.45K | $43.16K | -- |
| May 28, 08 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | $1.35 | 3.03M | $4.09M | -- |
| May 28, 08 | Griffin Jerry C | CTO | Purchase | $0.62 | 3.06K | $1.89K | 17.86K |
| May 28, 08 | Griffin Jerry C | CTO | Purchase | $0.62 | 14.81K | $9.18K | 14.81K |
| May 28, 08 | Griffin Jerry C | CTO | Sale | $0.62 | 3.06K | $1.89K | -- |
| May 28, 08 | Griffin Jerry C | CTO | Sale | $6.69 | 6.45K | $43.16K | -- |
| May 28, 08 | Griffin Jerry C | CTO | Sale | $1.35 | 17.86K | $24.12K | -- |
| May 28, 08 | Griffin Jerry C | CTO | Sale | $13.02 | 215 | $2.80K | -- |
| May 28, 08 | Griffin Jerry C | CTO | Sale | $2.35 | 6.45K | $15.16K | -- |
| Jun 14, 07 | ORBIMED ADVISORS LLC | 10 percent owner | Sale | -- | 842.50K | -- | 389.43K |
| May 14, 07 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | $6.69 | 6.45K | $43.16K | 6.45K |
| May 14, 07 | Griffin Jerry C | CTO | Purchase | $6.69 | 6.45K | $43.16K | 6.45K |
| Apr 24, 07 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | $5.14 | 96.55K | $496.28K | 1.94M |
| Apr 24, 07 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | $5.14 | 53.10K | $272.95K | 53.10K |
| Apr 24, 07 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | $5.14 | 96.55K | $496.27K | 3.03M |
| Apr 24, 07 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | $5.14 | 53.10K | $272.94K | 53.10K |
| May 3, 06 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | $2.35 | 6.45K | $15.16K | 6.45K |
| May 3, 06 | Griffin Jerry C | CTO | Purchase | $2.35 | 6.45K | $15.16K | 24.80K |
| May 3, 06 | Adelman Robert J | CTO | Purchase | $2.35 | 6.45K | $15.16K | 6.45K |
| Jul 13, 05 | ORBIMED ADVISORS LLC | CTO | Purchase | -- | 1.10M | -- | 1.23M |
| Jul 13, 05 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 30.24M | -- | -- |
| Jul 13, 05 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 1.10M | -- | -- |
| Jul 19, 05 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | -- | 1.65M | -- | 1.85M |
| Jul 19, 05 | William Blair Capital Management VII, LLC | 10 percent owner | Sale | -- | 45.36M | -- | -- |
| Jul 19, 05 | Adelman Robert J | CTO | Purchase | -- | 1.10M | -- | 1.23M |
| Jul 19, 05 | Adelman Robert J | CTO | Sale | -- | 30.24M | -- | -- |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | $8.37 | 121.94K | $1.02M | 3.02M |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | $11.00 | 92.79K | $1.02M | 2.93M |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | -- | 1.47M | -- | 2.90M |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | -- | 795.28K | -- | 1.43M |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | -- | 455.71K | -- | 635.71K |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 40.57M | -- | -- |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 1.62M | -- | -- |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | $8.37 | 121.94K | $1.02M | -- |
| Jul 19, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 3.34M | -- | -- |
| Jul 13, 05 | ORBIMED ADVISORS LLC | CTO | Purchase | $11.00 | 135.00K | $1.49M | 1.23M |
| Jul 13, 05 | Adelman Robert J | CTO | Purchase | $11.00 | 135.00K | $1.49M | 135.00K |
| Jul 13, 05 | ORBIMED ADVISORS LLC | 10 percent owner | Sale | -- | -- | -- | 1.10M |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Purchase | $11.00 | 180.00K | $1.98M | 180.00K |
| Jul 13, 05 | William Blair Capital Management VII, LLC | 10 percent owner | Purchase | $11.00 | 203.00K | $2.23M | 203.00K |
| Jul 13, 05 | Adelman Robert J | CTO | Sale | -- | 1.10M | -- | -- |
| Apr 17, 01 | Griffin Jerry C | CTO | Sale | $13.02 | 215 | $2.80K | -- |
| Jul 21, 04 | Griffin Jerry C | CTO | Sale | $0.62 | 14.81K | $9.18K | -- |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 1.47M | -- | -- |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 455.71K | -- | -- |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | -- | 795.28K | -- | -- |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | $13.02 | 4.78K | $62.21K | -- |
| Jul 13, 05 | MPM BIOVENTURES II QP LP | 10 percent owner | Sale | $8.37 | 121.94K | $1.02M | -- |
| Jul 13, 05 | William Blair Capital Management VII, LLC | 10 percent owner | Sale | -- | 1.65M | -- | -- |