| Aug 9, 23 | RA CAPITAL MANAGEMENT, L.P. | -- | Sale | $14.98 | 21.25K | $318.32K | -- |
| Aug 9, 23 | RA CAPITAL MANAGEMENT, L.P. | -- | Sale | $0.00 | 786.41K | $78.641 | -- |
| Aug 9, 23 | TETLOW SHARON | CTO | Sale | $14.98 | 21.25K | $318.32K | -- |
| Aug 9, 23 | TETLOW SHARON | CTO | Sale | $0.00 | 49.84K | $4.984 | -- |
| Aug 9, 23 | TETLOW SHARON | CTO | Sale | $17.00 | 13.80K | $234.60K | -- |
| Aug 9, 23 | Simson Jake | CTO | Sale | $14.98 | 21.25K | $318.32K | -- |
| Aug 9, 23 | Scopa James Paul | CTO | Sale | $17.00 | 13.80K | $234.60K | -- |
| Aug 9, 23 | Scopa James Paul | CTO | Sale | $14.98 | 21.25K | $318.32K | -- |
| Aug 9, 23 | Scopa James Paul | CTO | Sale | $0.00 | 25.72K | $2.572 | -- |
| Aug 9, 23 | Robertson Scott M. | CFO | Sale | $17.00 | 56.92K | $967.64K | -- |
| Aug 9, 23 | Robertson Scott M. | CFO | Sale | $0.00 | 198.00K | $19.8 | -- |
| Aug 9, 23 | Robertson Scott M. | CFO | Sale | $19.64 | 154.25K | $3.03M | -- |
| Aug 9, 23 | Robertson Scott M. | CFO | Sale | $32.31 | 112.50K | $3.63M | -- |
| Aug 9, 23 | Robertson Scott M. | CFO | Sale | -- | 18.75K | -- | -- |
| Aug 9, 23 | SCHELLER RICHARD H | CTO | Sale | $14.98 | 31.25K | $468.13K | -- |
| Aug 9, 23 | SCHELLER RICHARD H | CTO | Sale | $17.00 | 22.60K | $384.20K | -- |
| Aug 9, 23 | SCHELLER RICHARD H | CTO | Sale | $0.00 | 8.43K | $0.843 | -- |
| Aug 9, 23 | Timothy Lu | Officer | Sale | $17.00 | 43.17K | $733.84K | -- |
| Aug 9, 23 | Timothy Lu | Officer | Sale | $19.64 | 157.76K | $3.10M | -- |
| Aug 9, 23 | Timothy Lu | Officer | Sale | $32.31 | 90.00K | $2.91M | -- |
| Aug 9, 23 | Timothy Lu | Officer | Sale | $0.00 | 152.28K | $15.229 | -- |
| Aug 9, 23 | Timothy Lu | Officer | Sale | -- | 15.00K | -- | -- |
| Aug 9, 23 | Judice Kevin | CEO | Sale | $0.00 | 799.68K | $79.969 | -- |
| Aug 9, 23 | Judice Kevin | CEO | Sale | -- | 50.00K | -- | -- |
| Aug 9, 23 | Judice Kevin | CEO | Sale | $17.00 | 132.07K | $2.25M | -- |
| Aug 9, 23 | Judice Kevin | CEO | Sale | $19.64 | 384.90K | $7.56M | -- |
| Aug 9, 23 | Judice Kevin | CEO | Sale | $32.31 | 300.00K | $9.69M | -- |
| Aug 9, 23 | Jacobsen John R. | Officer | Sale | $17.00 | 46.32K | $787.51K | -- |
| Aug 9, 23 | Jacobsen John R. | Officer | Sale | $0.00 | 147.50K | $14.75 | -- |
| Aug 9, 23 | Jacobsen John R. | Officer | Sale | $19.64 | 154.25K | $3.03M | -- |
| Aug 9, 23 | Jacobsen John R. | Officer | Sale | $32.31 | 90.00K | $2.91M | -- |
| Aug 9, 23 | Jacobsen John R. | Officer | Sale | -- | 15.00K | -- | -- |
| Aug 9, 23 | Doyle Mittie | CTO | Sale | $19.13 | 42.50K | $813.02K | -- |
| Aug 9, 23 | Bowers Lisa | CTO | Sale | $19.13 | 42.50K | $813.02K | -- |
| Aug 2, 23 | Scopa James Paul | CTO | Sale | -- | 220 | -- | 27.92K |
| Aug 2, 23 | Scopa James Paul | CTO | Sale | -- | 2.20K | -- | 25.72K |
| Jul 18, 23 | Scopa James Paul | CTO | Sale | -- | 2.20K | -- | 28.14K |
| Jul 11, 23 | Scopa James Paul | CTO | Sale | -- | 300 | -- | 30.34K |
| Jun 22, 23 | Northpond Ventures GP, LLC | 10 percent owner | Sale | $46.50 | 1.97M | $91.58M | 633.71K |
| Jun 22, 23 | Northpond Ventures GP, LLC | 10 percent owner | Sale | $46.50 | 523.50K | $24.34M | 166.29K |
| Jun 1, 23 | Jacobsen John R. | Officer | Sale | $30.31 | 14.31K | $433.65K | 151.94K |
| Jun 1, 23 | Jacobsen John R. | Officer | Sale | $31.24 | 4.44K | $138.80K | 147.50K |
| May 5, 23 | SCHELLER RICHARD H | CTO | Sale | $38.51 | 84.10K | $3.24M | 8.43K |
| May 3, 23 | Robertson Scott M. | CFO | Sale | $36.55 | 18.75K | $685.35K | 198.00K |
| May 3, 23 | Timothy Lu | Officer | Sale | $36.54 | 10.00K | $365.40K | 152.28K |
| May 3, 23 | Judice Kevin | CEO | Sale | $36.50 | 13.70K | $499.98K | 799.68K |
| May 1, 23 | Scopa James Paul | CTO | Purchase | -- | 6.92K | -- | 30.64K |
| May 1, 23 | Scopa James Paul | CTO | Sale | -- | 6.92K | -- | 15.20K |
| Apr 18, 23 | Jacobsen John R. | Officer | Sale | $30.08 | 16.39K | $493.13K | 166.25K |
| Mar 31, 23 | Jacobsen John R. | Officer | Sale | $30.00 | 773 | $23.19K | 182.64K |
| Mar 30, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $28.74 | 196.00K | $5.63M | 7.07M |
| Mar 29, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $29.38 | 66.37K | $1.95M | 6.87M |
| Mar 28, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $29.24 | 246.78K | $7.22M | 6.81M |
| Mar 28, 23 | Jacobsen John R. | Officer | Sale | $30.09 | 500 | $15.04K | 184.51K |
| Mar 29, 23 | Jacobsen John R. | Officer | Sale | $30.00 | 1.09K | $32.82K | 183.41K |
| Mar 27, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $27.48 | 151.13K | $4.15M | 6.56M |
| Mar 24, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $26.87 | 192.34K | $5.17M | 6.41M |
| Mar 23, 23 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $26.67 | 155.09K | $4.14M | 6.22M |
| Oct 24, 22 | Scopa James Paul | CTO | Purchase | -- | 30.72K | -- | 33.72K |
| Mar 17, 23 | Scopa James Paul | CTO | Sale | $29.05 | 10.00K | $290.50K | 23.72K |
| Oct 24, 22 | Scopa James Paul | CTO | Sale | -- | 30.72K | -- | 22.12K |
| Jan 27, 23 | Robertson Scott M. | CFO | Purchase | $32.31 | 112.50K | $3.63M | 112.50K |
| Jan 27, 23 | Robertson Scott M. | CFO | Purchase | -- | 18.75K | -- | 18.75K |
| Jan 27, 23 | Timothy Lu | Officer | Purchase | $32.31 | 90.00K | $2.91M | 90.00K |
| Jan 27, 23 | Timothy Lu | Officer | Purchase | -- | 15.00K | -- | 15.00K |
| Jan 27, 23 | Judice Kevin | CEO | Purchase | $32.31 | 300.00K | $9.69M | 300.00K |
| Jan 27, 23 | Judice Kevin | CEO | Purchase | -- | 50.00K | -- | 50.00K |
| Jan 27, 23 | Jacobsen John R. | Officer | Purchase | $32.31 | 90.00K | $2.91M | 90.00K |
| Jan 27, 23 | Jacobsen John R. | Officer | Purchase | -- | 15.00K | -- | 15.00K |
| Oct 17, 22 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $36.50 | 1.64M | $59.86M | 6.85M |
| Jun 7, 22 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $14.98 | 21.25K | $318.32K | 21.25K |
| Jun 7, 22 | Shah Rajeev M. | CTO | Purchase | -- | 21.25K | -- | 21.25K |
| Jun 7, 22 | TETLOW SHARON | CTO | Purchase | $14.98 | 21.25K | $318.32K | 21.25K |
| Jun 7, 22 | TETLOW SHARON | CTO | Purchase | -- | 21.25K | -- | 21.25K |
| Jun 7, 22 | Simson Jake | CTO | Purchase | -- | 21.25K | -- | 21.25K |
| Jun 7, 22 | Scopa James Paul | CTO | Purchase | $14.98 | 21.25K | $318.32K | 21.25K |
| Jun 7, 22 | Scopa James Paul | CTO | Purchase | -- | 21.25K | -- | 21.25K |
| Jun 7, 22 | SCHELLER RICHARD H | CTO | Purchase | $14.98 | 31.25K | $468.13K | 31.25K |
| Jun 7, 22 | SCHELLER RICHARD H | CTO | Purchase | -- | 31.25K | -- | 31.25K |
| Apr 14, 22 | Robertson Scott M. | CFO | Purchase | -- | 154.25K | -- | 154.25K |
| Apr 14, 22 | Timothy Lu | Officer | Purchase | -- | 157.76K | -- | 157.76K |
| Apr 14, 22 | Judice Kevin | CEO | Purchase | -- | 384.90K | -- | 384.90K |
| Apr 14, 22 | Jacobsen John R. | Officer | Purchase | -- | 154.25K | -- | 154.25K |
| Mar 31, 22 | Doyle Mittie | CTO | Purchase | -- | 42.50K | -- | 42.50K |
| Mar 31, 22 | Bowers Lisa | CTO | Purchase | -- | 42.50K | -- | 42.50K |
| Mar 24, 22 | Doyle Mittie | CTO | Sale | -- | -- | -- | -- |
| Mar 24, 22 | Bowers Lisa | CTO | Sale | -- | -- | -- | -- |
| Dec 30, 21 | Scopa James Paul | CTO | Sale | -- | 3.00K | -- | 52.84K |
| Dec 30, 21 | Scopa James Paul | CTO | Purchase | -- | 3.00K | -- | 3.00K |
| Dec 31, 21 | Scopa James Paul | CTO | Sale | -- | -- | -- | -- |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Purchase | $17.00 | 235.00K | $4.00M | 3.29M |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Purchase | $0.00 | 454.80K | $45.48 | 3.06M |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Purchase | $0.00 | 2.60M | $260.308 | 2.60M |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 867.69K | -- | -- |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 454.80K | -- | -- |
| Sep 17, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 1.74M | -- | -- |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $17.00 | 1.32M | $22.48M | 4.42M |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | -- | 3.10M | -- | 3.10M |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | $17.00 | 77.58K | $1.32M | 786.41K |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | -- | 708.83K | -- | 708.83K |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Sale | -- | 433.84K | -- | -- |
| Sep 17, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Sale | -- | 274.99K | -- | -- |
| Sep 15, 21 | Scopa James Paul | CTO | Purchase | $17.00 | 6.00K | $102.00K | 55.84K |
| Sep 14, 21 | Scopa James Paul | CTO | Purchase | $17.00 | 12.10K | $205.63K | 12.10K |
| Sep 14, 21 | Scopa James Paul | CTO | Purchase | $17.00 | 8.26K | $140.44K | 8.26K |
| Sep 14, 21 | Scopa James Paul | CTO | Purchase | $17.00 | 8.20K | $139.40K | 8.20K |
| Sep 14, 21 | Scopa James Paul | CTO | Purchase | $17.00 | 5.60K | $95.20K | 5.60K |
| Sep 14, 21 | TETLOW SHARON | CTO | Purchase | $17.00 | 12.10K | $205.63K | 12.10K |
| Sep 14, 21 | TETLOW SHARON | CTO | Purchase | $17.00 | 8.26K | $140.44K | 8.26K |
| Sep 14, 21 | TETLOW SHARON | CTO | Purchase | $17.00 | 8.20K | $139.40K | 8.20K |
| Sep 14, 21 | TETLOW SHARON | CTO | Purchase | $17.00 | 5.60K | $95.20K | 5.60K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Purchase | $17.00 | 9.14K | $155.35K | 9.14K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Purchase | $17.00 | 8.50K | $144.50K | 8.50K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Purchase | $17.00 | 8.26K | $140.44K | 8.26K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Purchase | $17.00 | 5.60K | $95.20K | 5.60K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Purchase | $17.00 | 4.36K | $74.07K | 4.36K |
| Sep 14, 21 | Timothy Lu | Officer | Purchase | $17.00 | 31.30K | $532.17K | 31.30K |
| Sep 14, 21 | Timothy Lu | Officer | Purchase | $17.00 | 25.82K | $438.89K | 25.82K |
| Sep 14, 21 | Timothy Lu | Officer | Purchase | $17.00 | 25.59K | $435.08K | 25.59K |
| Sep 14, 21 | Timothy Lu | Officer | Purchase | $17.00 | 17.35K | $294.95K | 17.35K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 14.34K | $243.80K | 14.34K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 12.20K | $207.47K | 12.20K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 11.06K | $188.09K | 11.06K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 8.52K | $144.84K | 8.52K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 7.58K | $128.84K | 7.58K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 7.50K | $127.50K | 7.50K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 6.25K | $106.25K | 6.25K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 4.41K | $74.94K | 4.41K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 4.37K | $74.24K | 4.37K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 4.23K | $71.89K | 4.23K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 4.08K | $69.28K | 4.08K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 3.75K | $63.75K | 3.75K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 1.52K | $25.93K | 1.52K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 1.34K | $22.85K | 1.34K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 1.28K | $21.73K | 1.28K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 1.25K | $21.25K | 1.25K |
| Sep 14, 21 | Jacobsen John R. | Officer | Purchase | $17.00 | 922 | $15.67K | 922 |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 20.75K | $352.77K | 20.75K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 20.00K | $340.00K | 20.00K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 16.59K | $282.12K | 16.59K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 15.00K | $255.00K | 15.00K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 11.25K | $191.25K | 11.25K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 9.75K | $165.75K | 9.75K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 9.10K | $154.62K | 9.10K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 7.50K | $127.50K | 7.50K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 7.19K | $122.25K | 7.19K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 5.00K | $85.00K | 5.00K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 2.69K | $45.70K | 2.69K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 2.50K | $42.50K | 2.50K |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 920 | $15.64K | 920 |
| Sep 14, 21 | Robertson Scott M. | CFO | Purchase | $17.00 | 771 | $13.11K | 771 |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 131.03K | $2.23M | 131.03K |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 88.83K | $1.51M | 88.83K |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 27.75K | $471.68K | 27.75K |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 20.46K | $347.89K | 20.46K |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 16.66K | $283.24K | 16.66K |
| Sep 14, 21 | Judice Kevin | CEO | Purchase | $17.00 | 15.50K | $263.45K | 15.50K |
| Sep 14, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 867.69K | -- | -- |
| Sep 14, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 1.74M | -- | -- |
| Sep 14, 21 | Northpond Ventures GP, LLC | 10 percent owner | Sale | -- | 454.80K | -- | -- |
| Sep 14, 21 | Zachary Stephen | CTO | Sale | -- | -- | -- | -- |
| Sep 14, 21 | Scopa James Paul | CTO | Sale | -- | -- | -- | 69.00K |
| Sep 14, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Sale | -- | 274.99K | -- | -- |
| Sep 14, 21 | RA CAPITAL MANAGEMENT, L.P. | CTO | Sale | -- | 433.84K | -- | -- |
| Sep 14, 21 | Gandhi Shaan-Chirag C | CTO | Sale | -- | -- | -- | -- |
| Sep 14, 21 | TETLOW SHARON | CTO | Sale | -- | -- | -- | 69.00K |
| Sep 14, 21 | SCHELLER RICHARD H | CTO | Sale | -- | -- | -- | 113.00K |
| Sep 14, 21 | Timothy Lu | Officer | Sale | -- | -- | -- | 215.84K |
| Sep 14, 21 | Simson Jake | CTO | Sale | -- | -- | -- | -- |
| Sep 14, 21 | Jacobsen John R. | Officer | Sale | -- | -- | -- | 231.63K |
| Sep 14, 21 | Robertson Scott M. | CFO | Sale | -- | -- | -- | 284.60K |
| Sep 14, 21 | Judice Kevin | CEO | Sale | -- | -- | -- | 971.64K |