| BVF INC/IL | 1.11M | Jun 30, 26 | -- | 9.78% |
| Blue Owl Capital Holdings LP | 917.69K | Jun 30, 26 | -41.65K | 8.08% |
| ORBIMED ADVISORS LLC | 909.27K | Jun 30, 26 | +530.71K | 8.01% |
| Cable Car Capital LLC | 781.60K | Jun 30, 26 | +26.85K | 6.89% |
| Omega Fund Management, LLC | 455.36K | Jun 30, 26 | -- | 4.01% |
| RTW INVESTMENTS, LP | 334.44K | Jun 30, 26 | -- | 2.95% |
| VANGUARD CAPITAL MANAGEMENT LLC | 320.52K | Jun 30, 26 | -4.64K | 2.82% |
| Trails Edge Capital Partners, LP | 282.00K | Jun 30, 26 | +282.00K | 2.48% |
| BML Capital Management, LLC | 200.73K | Jun 30, 26 | -- | 1.77% |
| Monashee Investment Management LLC | 192.34K | Jun 30, 26 | +192.34K | 1.69% |
| BlackRock, Inc. | 135.09K | Jun 30, 26 | +5.88K | 1.19% |
| Stonepine Capital Management, LLC | 96.17K | Jun 30, 26 | +96.17K | 0.85% |
| RENAISSANCE TECHNOLOGIES LLC | 86.93K | Jun 30, 26 | +5.23K | 0.77% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 66.67K | Jun 30, 26 | -- | 0.59% |
| CITADEL ADVISORS LLC | 55.61K | Jun 30, 26 | -68.73K | 0.49% |
| GEODE CAPITAL MANAGEMENT, LLC | 53.51K | Jun 30, 26 | -6.42K | 0.47% |
| NEA Management Company, LLC | 50.01K | Jun 30, 26 | -- | 0.44% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 50.00K | Jun 30, 26 | +20.00K | 0.44% |
| HSBC HOLDINGS PLC | 34.23K | Jun 30, 26 | -656 | 0.30% |
| Sofinnova Investments, Inc. | 31.88K | Jun 30, 26 | -- | 0.28% |
| VANGUARD FIDUCIARY TRUST CO | 27.48K | Jun 30, 26 | +189 | 0.24% |
| Rangeley Capital, LLC | 20.09K | Jun 30, 26 | -12.50K | 0.18% |
| TWO SIGMA INVESTMENTS, LP | 19.90K | Jun 30, 26 | +19.90K | 0.18% |
| Aldebaran Capital, LLC | 18.12K | Jun 30, 26 | -442 | 0.16% |
| Shay Capital LLC | 18.08K | Jun 30, 26 | -1.05K | 0.16% |
| MORGAN STANLEY | 16.68K | Jun 30, 26 | -1.66K | 0.15% |
| GOLDMAN SACHS GROUP INC | 15.48K | Jun 30, 26 | +4.03K | 0.14% |
| NORTHERN TRUST CORP | 11.27K | Jun 30, 26 | +11.27K | 0.10% |
| BARCLAYS PLC | 10.80K | Jun 30, 26 | -162 | 0.10% |
| UBS Group AG | 6.88K | Jun 30, 26 | +1.45K | 0.06% |
| Tower Research Capital LLC (TRC) | 675 | Jun 30, 26 | -336 | 0.01% |
| Vanguard Global Advisers, LLC | 602 | Jun 30, 26 | -- | 0.01% |
| Caitong International Asset Management Co., Ltd | 464 | Jun 30, 26 | +462 | 0.00% |
| NewEdge Advisors, LLC | 160 | Jun 30, 26 | -- | 0.00% |
| JPMORGAN CHASE & CO | 70 | Jun 30, 26 | -223 | 0.00% |
| BNP PARIBAS ARBITRAGE, SNC | 24 | Jun 30, 26 | -- | 0.00% |
| CITIGROUP INC | -- | Jun 30, 26 | -224 | -- |
| XTX Topco Ltd | -- | Jun 30, 26 | -15.11K | -- |
| JACOBS LEVY EQUITY MANAGEMENT, INC | -- | Jun 30, 26 | -26.66K | -- |
| WELLS FARGO & COMPANY/MN | -- | Jun 30, 26 | -41 | -- |
| JANE STREET GROUP, LLC | -- | Jun 30, 26 | -13.21K | -- |
| HRT FINANCIAL LP | -- | Jun 30, 26 | -13.91K | -- |
| ROYAL BANK OF CANADA | -- | Jun 30, 26 | -1.00K | -- |
| PRELUDE CAPITAL MANAGEMENT, LLC | -- | Jun 30, 26 | -12.99K | -- |
| VANGUARD GROUP INC | 238.00K | Dec 31, 25 | +4.64K | 2.10% |