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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Apr 1, 21 | Viney Joanne L. | Officer | Sale | $60.00 | 1.20K | $72.00K | -- |
| Apr 1, 21 | Viney Joanne L. | Officer | Sale | $18.00 | 114.88K | $2.07M | -- |
| Apr 1, 21 | Viney Joanne L. | Officer | Sale | $17.75 | 73.79K | $1.31M | -- |
| Apr 1, 21 | Goyal Vikas | Officer | Sale | $60.00 | 87.76K | $5.27M | -- |
| Apr 1, 21 | Goyal Vikas | Officer | Sale | $17.75 | 73.79K | $1.31M | -- |
| Apr 1, 21 | Goyal Vikas | Officer | Sale | $18.00 | 28.23K | $508.09K | -- |
| Apr 1, 21 | Freedman Edward D. | COO | Sale | $17.75 | 36.90K | $654.89K | -- |
| Apr 1, 21 | Freedman Edward D. | COO | Sale | $18.00 | 55.90K | $1.01M | -- |
| Apr 1, 21 | Freedman Edward D. | COO | Sale | $60.00 | 54.46K | $3.27M | -- |
| Apr 1, 21 | BELOFF GREGG | Officer | Sale | $60.00 | 13.20K | $791.76K | -- |
| Apr 1, 21 | Kakkar Rahul | CEO | Sale | $60.00 | 702.51K | $42.15M | -- |
| Apr 1, 21 | Kakkar Rahul | CEO | Sale | $17.75 | 221.37K | $3.93M | -- |
| Apr 1, 21 | Kakkar Rahul | CEO | Sale | $18.00 | 348.74K | $6.28M | -- |
| Apr 1, 21 | Fuglesang Christopher | CTO | Sale | $18.00 | 14.00K | $251.95K | -- |
| Apr 1, 21 | Fuglesang Christopher | CTO | Sale | $60.00 | 23.62K | $1.42M | -- |
| Apr 1, 21 | Becker Daniel J. | CTO | Sale | $18.00 | 14.00K | $251.95K | -- |
| Apr 1, 21 | Becker Daniel J. | CTO | Sale | $60.00 | 2.83M | $169.67M | -- |
| Apr 1, 21 | Dorton Katina | CTO | Sale | $16.96 | 27.99K | $474.78K | -- |
| Apr 1, 21 | Frail Donald | CTO | Sale | $18.00 | 18.75K | $337.45K | -- |
| Apr 1, 21 | Frail Donald | CTO | Sale | $60.00 | 61.11K | $3.67M | -- |
| Apr 1, 21 | Carroll Jill | CTO | Sale | $18.00 | 14.00K | $251.95K | -- |
| Apr 1, 21 | Carroll Jill | CTO | Sale | $60.00 | 5.67M | $340.45M | -- |
| Feb 24, 21 | Merck & Co., Inc. | 10 percent owner | Sale | -- | -- | -- | -- |
| Feb 24, 21 | Merck & Co., Inc. | 10 percent owner | Sale | -- | -- | -- | -- |
| Feb 8, 21 | Kakkar Rahul | CEO | Purchase | $17.75 | 221.37K | $3.93M | 221.37K |
| Feb 8, 21 | Freedman Edward D. | COO | Purchase | $17.75 | 36.90K | $654.89K | 36.90K |
| Feb 8, 21 | Viney Joanne L. | Officer | Purchase | $17.75 | 73.79K | $1.31M | 73.79K |
| Feb 8, 21 | Goyal Vikas | Officer | Purchase | $17.75 | 73.79K | $1.31M | 73.79K |
| Dec 2, 20 | Dorton Katina | CTO | Purchase | $16.96 | 27.99K | $474.78K | 27.99K |
| Dec 2, 20 | Dorton Katina | CTO | Sale | -- | -- | -- | -- |
| Nov 19, 20 | Becker Daniel J. | CTO | Purchase | $15.12 | 197.72K | $2.99M | 2.83M |
| Nov 18, 20 | Becker Daniel J. | CTO | Purchase | $15.26 | 14.20K | $216.65K | 2.63M |
| Nov 17, 20 | Becker Daniel J. | CTO | Purchase | $15.43 | 13.03K | $201.01K | 2.62M |
| Nov 17, 20 | Becker Daniel J. | CTO | Purchase | $14.63 | 2.17K | $31.75K | 2.60M |
| Jul 21, 20 | ROCHE HOLDING LTD | 10 percent owner | Purchase | $18.00 | 36.11K | $650.00K | 3.09M |
| Jul 21, 20 | ROCHE HOLDING LTD | 10 percent owner | Purchase | -- | 3.05M | -- | 3.05M |
| Jul 21, 20 | ROCHE HOLDING LTD | 10 percent owner | Sale | -- | 13.14M | -- | -- |
| Jul 21, 20 | ROCHE HOLDING LTD | 10 percent owner | Sale | -- | 2.41M | -- | -- |
| Jul 21, 20 | Mutz Mitchell | CTO | Purchase | $18.00 | 36.11K | $650.00K | 3.09M |
| Jul 21, 20 | Mutz Mitchell | CTO | Purchase | -- | 3.05M | -- | 3.05M |
| Jul 21, 20 | Mutz Mitchell | CTO | Purchase | $18.00 | 10.00K | $180.00K | 10.00K |
| Jul 21, 20 | Mutz Mitchell | CTO | Sale | -- | 2.41M | -- | -- |
| Jul 21, 20 | Mutz Mitchell | CTO | Sale | -- | 13.14M | -- | -- |
| Jul 21, 20 | RA CAPITAL MANAGEMENT, L.P. | 10 percent owner | Purchase | $18.00 | 361.11K | $6.50M | 1.77M |
| Jul 21, 20 | RA CAPITAL MANAGEMENT, L.P. | 10 percent owner | Purchase | -- | 1.41M | -- | 1.41M |
| Jul 21, 20 | RA CAPITAL MANAGEMENT, L.P. | 10 percent owner | Sale | -- | 7.18M | -- | -- |
| Jul 21, 20 | GLAXOSMITHKLINE PLC | CTO | Purchase | $18.00 | 361.11K | $6.50M | 2.25M |
| Jul 21, 20 | GLAXOSMITHKLINE PLC | CTO | Purchase | -- | 348.47K | -- | 1.89M |
| Jul 21, 20 | GLAXOSMITHKLINE PLC | CTO | Purchase | -- | 1.54M | -- | 1.54M |
| Jul 17, 20 | GLAXOSMITHKLINE PLC | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 21, 20 | GLAXOSMITHKLINE PLC | CTO | Sale | -- | 7.85M | -- | -- |
| Jul 21, 20 | GLAXOSMITHKLINE PLC | CTO | Sale | -- | 1.78M | -- | -- |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | $18.00 | 34.86K | $627.53K | 3.09M |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | -- | 272.05K | -- | 3.06M |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | -- | 2.78M | -- | 2.78M |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | $18.00 | 1.25K | $22.46K | 110.62K |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | -- | 9.74K | -- | 109.37K |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Purchase | -- | 99.64K | -- | 99.64K |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Sale | -- | 508.09K | -- | -- |
| Jul 21, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Sale | -- | 49.65K | -- | -- |
| Jul 17, 20 | Mutz Mitchell | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 21, 20 | Boxer Capital, LLC | 10 percent owner | Purchase | $18.00 | 722.22K | $13.00M | 2.11M |
| Jul 21, 20 | Boxer Capital, LLC | 10 percent owner | Purchase | -- | 1.39M | -- | 1.39M |
| Jul 21, 20 | Boxer Capital, LLC | 10 percent owner | Purchase | -- | 23.62K | -- | 23.62K |
| Jul 21, 20 | Boxer Capital, LLC | 10 percent owner | Sale | -- | 120.46K | -- | -- |
| Jul 21, 20 | Carroll Jill | CTO | Purchase | $18.00 | 361.11K | $6.50M | 2.25M |
| Jul 21, 20 | Carroll Jill | CTO | Purchase | -- | 348.47K | -- | 1.89M |
| Jul 21, 20 | Carroll Jill | CTO | Purchase | -- | 1.54M | -- | 1.54M |
| Jul 17, 20 | Carroll Jill | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 21, 20 | Carroll Jill | CTO | Sale | -- | 1.78M | -- | -- |
| Jul 21, 20 | Carroll Jill | CTO | Sale | -- | 7.85M | -- | -- |
| Jul 21, 20 | JDRF T1D Fund LLC | 10 percent owner | Purchase | -- | 222.02K | -- | 426.33K |
| Jul 21, 20 | JDRF T1D Fund LLC | 10 percent owner | Purchase | -- | 204.31K | -- | 204.31K |
| Jul 21, 20 | JDRF T1D Fund LLC | 10 percent owner | Sale | -- | 1.13M | -- | -- |
| Jul 21, 20 | JDRF T1D Fund LLC | 10 percent owner | Sale | -- | 948.23K | -- | -- |
| Jul 21, 20 | Fuglesang Christopher | CTO | Purchase | $18.00 | 722.22K | $13.00M | 2.60M |
| Jul 21, 20 | Fuglesang Christopher | CTO | Purchase | -- | 1.41M | -- | 1.41M |
| Jul 17, 20 | Fuglesang Christopher | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 21, 20 | Fuglesang Christopher | CTO | Sale | -- | 7.18M | -- | -- |
| Jul 21, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Purchase | -- | 3.18M | -- | 3.18M |
| Jul 21, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Purchase | -- | 577.54K | -- | 577.54K |
| Jul 21, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 1.25M | -- | -- |
| Jul 21, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 14.45M | -- | -- |
| Jul 21, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 333.33K | -- | -- |
| Jul 21, 20 | Becker Daniel J. | CTO | Purchase | $18.00 | 722.22K | $13.00M | 2.60M |
| Jul 21, 20 | Becker Daniel J. | CTO | Purchase | -- | 1.88M | -- | 1.88M |
| Jul 17, 20 | Becker Daniel J. | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 21, 20 | Becker Daniel J. | CTO | Purchase | $18.00 | 1.00K | $18.00K | 1.00K |
| Jul 21, 20 | Becker Daniel J. | CTO | Sale | -- | 9.58M | -- | -- |
| Jul 21, 20 | Goyal Vikas | Officer | Purchase | $18.00 | 1.45K | $26.10K | 87.76K |
| Jul 21, 20 | Goyal Vikas | Officer | Purchase | -- | 7.04K | -- | 86.31K |
| Jul 17, 20 | Goyal Vikas | Officer | Purchase | $18.00 | 13.94K | $250.83K | 13.94K |
| Jul 17, 20 | Goyal Vikas | Officer | Purchase | $18.00 | 10.49K | $188.75K | 10.49K |
| Jul 17, 20 | Goyal Vikas | Officer | Purchase | $18.00 | 3.81K | $68.51K | 3.81K |
| Jul 21, 20 | Goyal Vikas | Officer | Sale | -- | 35.92K | -- | -- |
| Jul 21, 20 | Kakkar Rahul | CEO | Purchase | -- | 21.13K | -- | 702.51K |
| Jul 17, 20 | Kakkar Rahul | CEO | Purchase | $18.00 | 221.07K | $3.98M | 221.07K |
| Jul 17, 20 | Kakkar Rahul | CEO | Purchase | $18.00 | 100.49K | $1.81M | 100.49K |
| Jul 17, 20 | Kakkar Rahul | CEO | Purchase | $18.00 | 27.18K | $489.26K | 27.18K |
| Jul 21, 20 | Kakkar Rahul | CEO | Purchase | $18.00 | 14.00K | $252.00K | 14.00K |
| Jul 21, 20 | Kakkar Rahul | CEO | Sale | -- | 107.77K | -- | -- |
| Jul 21, 20 | Viney Joanne L. | Officer | Purchase | -- | 21.13K | -- | 503.25K |
| Jul 17, 20 | Viney Joanne L. | Officer | Purchase | $18.00 | 58.24K | $1.05M | 58.24K |
| Jul 17, 20 | Viney Joanne L. | Officer | Purchase | $18.00 | 56.64K | $1.02M | 56.64K |
| Jul 21, 20 | Viney Joanne L. | Officer | Purchase | $18.00 | 1.20K | $21.60K | 1.20K |
| Jul 21, 20 | Viney Joanne L. | Officer | Sale | -- | 107.77K | -- | -- |
| Jul 21, 20 | Frail Donald | CTO | Purchase | $18.00 | 10.00K | $180.00K | 61.11K |
| Jul 21, 20 | Frail Donald | CTO | Purchase | -- | 11.74K | -- | 51.11K |
| Jul 17, 20 | Frail Donald | CTO | Purchase | $18.00 | 14.00K | $251.95K | 14.00K |
| Jul 17, 20 | Frail Donald | CTO | Purchase | $18.00 | 4.75K | $85.50K | 4.75K |
| Jul 21, 20 | Frail Donald | CTO | Sale | -- | 59.87K | -- | -- |
| Jul 21, 20 | Freedman Edward D. | COO | Purchase | -- | 2.35K | -- | 54.46K |
| Jul 17, 20 | Freedman Edward D. | COO | Purchase | $18.00 | 53.13K | $956.36K | 53.13K |
| Jul 17, 20 | Freedman Edward D. | COO | Purchase | $18.00 | 2.11K | $38.02K | 2.11K |
| Jul 17, 20 | Freedman Edward D. | COO | Purchase | $18.00 | 660 | $11.88K | 660 |
| Jul 21, 20 | Freedman Edward D. | COO | Sale | -- | 11.97K | -- | -- |
| Jul 16, 20 | Access Industries Holdings LLC | 10 percent owner | Sale | -- | 1.88M | -- | -- |
| Jul 16, 20 | GLAXOSMITHKLINE PLC | CTO | Sale | -- | 1.54M | -- | -- |
| Jul 16, 20 | GLAXOSMITHKLINE PLC | CTO | Sale | -- | 348.47K | -- | -- |
| Jul 16, 20 | RA CAPITAL MANAGEMENT, L.P. | 10 percent owner | Sale | -- | 1.41M | -- | -- |
| Jul 16, 20 | ORBIMED ADVISORS LLC | 10 percent owner | Sale | -- | 469.64K | -- | -- |
| Jul 16, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 333.33K | -- | -- |
| Jul 16, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 244.21K | -- | -- |
| Jul 16, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 342.29K | -- | -- |
| Jul 16, 20 | Versant Venture Capital VI, L.P. | 10 percent owner | Sale | -- | 2.83M | -- | -- |
| Jul 16, 20 | Goyal Vikas | Officer | Sale | -- | -- | -- | 79.27K |
| Jul 16, 20 | Goyal Vikas | Officer | Sale | -- | 7.04K | -- | -- |
| Jul 16, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Sale | -- | 9.74K | -- | -- |
| Jul 16, 20 | Polaris Partners GP VIII, L.L.C. | 10 percent owner | Sale | -- | 99.64K | -- | -- |
| Jul 16, 20 | ROCHE HOLDING LTD | 10 percent owner | Sale | -- | 473.41K | -- | -- |
| Jul 16, 20 | ROCHE HOLDING LTD | 10 percent owner | Sale | -- | 2.58M | -- | -- |
| Jul 16, 20 | Kakkar Rahul | CEO | Sale | -- | -- | -- | 681.38K |
| Jul 16, 20 | Kakkar Rahul | CEO | Sale | -- | 21.13K | -- | -- |
| Jul 16, 20 | Boxer Capital, LLC | 10 percent owner | Sale | -- | 1.39M | -- | -- |
| Jul 16, 20 | Boxer Capital, LLC | 10 percent owner | Sale | -- | 23.62K | -- | -- |
| Jul 16, 20 | Mutz Mitchell | CTO | Sale | -- | 2.58M | -- | -- |
| Jul 16, 20 | Mutz Mitchell | CTO | Sale | -- | 473.41K | -- | -- |
| Jul 16, 20 | Carroll Jill | CTO | Sale | -- | 1.54M | -- | -- |
| Jul 16, 20 | Carroll Jill | CTO | Sale | -- | 348.47K | -- | -- |
| Jul 16, 20 | BELOFF GREGG | Officer | Sale | -- | -- | -- | 13.20K |
| Jul 16, 20 | JDRF T1D Fund LLC | 10 percent owner | Sale | -- | 204.31K | -- | -- |
| Jul 16, 20 | JDRF T1D Fund LLC | 10 percent owner | Sale | -- | 222.02K | -- | -- |
| Jul 16, 20 | Frail Donald | CTO | Sale | -- | -- | -- | 39.37K |
| Jul 16, 20 | Frail Donald | CTO | Sale | -- | 11.74K | -- | -- |
| Jul 16, 20 | Viney Joanne L. | Officer | Sale | -- | -- | -- | 482.12K |
| Jul 16, 20 | Viney Joanne L. | Officer | Sale | -- | 21.13K | -- | -- |
| Jul 16, 20 | Becker Daniel J. | CTO | Sale | -- | 1.88M | -- | -- |
| Jul 16, 20 | Freedman Edward D. | COO | Sale | -- | -- | -- | 52.11K |
| Jul 16, 20 | Freedman Edward D. | COO | Sale | -- | 2.35K | -- | -- |
| Jul 16, 20 | Fuglesang Christopher | CTO | Sale | -- | 1.41M | -- | -- |
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