Protagonist Therapeutics, Inc.PTGXNASDAQ

Revenue (LTM)

$46M

-89.4% YoY

Net Income (LTM)

$-130M

-147.3% YoY

Free Cash Flow

$56M

Revenue CAGR (5Y)

+10.0%

—Marginsstable

FCF$0.1B

Now unprofitable

Metric	Dec 21	Dec 22	Dec 23	Dec 24	Dec 25
Revenue	27	27↓2.8%	60↑125.7%	434↑624.1%	46↓89.4%
Gross Profit	27	27↓2.8%	60↑125.7%	434↑624.1%	45↓89.7%
Operating Income	-126	-131↓4.4%	-94↑28.7%	253↑370.0%	-158↓162.5%
Net Income	-126	-127↓1.5%	-79↑38.0%	275↑448.5%	-130↓147.3%
EBITDA	-123	-128↓4.0%	-90↑29.4%	254↑380.8%	-128↓150.5%
EPS Diluted	-2.65	-2.52↑4.9%	-1.39↑44.8%	4.23↑404.3%	-2.05↓148.5%

Metric	Dec 21	Dec 22	Dec 23	Dec 24	Dec 25
Cash & Equivalents	124	126↑1.7%	187↑48.5%	97↓47.9%	128↑32.0%
Total Current Assets	341	243↓28.7%	356↑46.3%	592↑66.4%	578↓2.4%
Total Assets	348	248↓28.7%	358↑44.4%	745↑108.1%	670↓10.0%
Total Current Liabilities	44	31↓29.2%	21↓31.8%	47↑122.8%	45↓4.1%
Total Liabilities	48	32↓32.2%	21↓34.2%	69↑226.4%	55↓20.5%
Total Equity	300	216↓28.1%	337↑56.2%	675↑100.6%	615↓9.0%
Total Debt	6	4↓37.6%	1↓68.8%	11↑852.3%	10↓5.0%
Net Debt	-118	-122↓3.6%	-186↓52.0%	-86↑53.5%	-118↓36.7%

Metric	Dec 21	Dec 22	Dec 23	Dec 24	Dec 25
Operating Cash Flow	-108	-108↓0.3%	-70↑35.0%	184↑362.2%	58↓68.7%
Capital Expenditure	-1	-1↑27.8%	-1↑23.4%	-1↓122.5%	-2↓17.3%
Free Cash Flow	-109	-109↑0.0%	-71↑35.0%	183↑358.0%	56↓69.3%
Stock-Based Comp	16	24↑47.6%	29↑21.0%	38↑28.2%	46↑22.4%
Net Change in Cash	6	2↓65.8%	61↑2833.3%	-89↓246.7%	31↑134.8%

Values in millions except EPS · Ratios shown as percentages · Click any metric to drill down

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