| Dec 14, 21 | Dorsey Brian | COO | Sale | $1.44 | 82.73K | $119.14K | -- |
| Dec 1, 22 | Fitzpatrick Alexander A | -- | Sale | -- | -- | -- | -- |
| Dec 1, 22 | Fitzpatrick Alexander A | Officer | Sale | -- | -- | -- | -- |
| Nov 29, 22 | Scott Kathleen D. | CFO | Purchase | $6.24 | 8.25K | $51.51K | 8.25K |
| Nov 8, 22 | Flynn James E | CTO | Sale | -- | -- | -- | 5.54M |
| Nov 8, 22 | Chakma Justin | Officer | Purchase | -- | 236.38K | -- | 236.38K |
| Nov 8, 22 | Chakma Justin | Officer | Purchase | -- | 82.73K | -- | 82.73K |
| Nov 8, 22 | Chakma Justin | Officer | Purchase | -- | 48.26K | -- | 48.26K |
| Nov 8, 22 | Shah Pratik | CTO | Purchase | -- | 10.16M | -- | 10.16M |
| Nov 8, 22 | Shah Pratik | CTO | Purchase | -- | 354.57K | -- | 354.57K |
| Nov 8, 22 | Karas Eric | Officer | Purchase | -- | 614.59K | -- | 614.59K |
| Nov 8, 22 | SCHNEIDER PHILLIP M | CTO | Purchase | -- | 153.65K | -- | 153.65K |
| Nov 8, 22 | SCHNEIDER PHILLIP M | CTO | Purchase | -- | 76.82K | -- | 76.82K |
| Nov 8, 22 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | -- | 2.11M | -- | 2.11M |
| Nov 8, 22 | RA CAPITAL MANAGEMENT, L.P. | CTO | Purchase | -- | 902.90K | -- | 902.90K |
| Nov 8, 22 | Tanimoto Sarina | Officer | Purchase | -- | 4.33M | -- | 4.33M |
| Nov 8, 22 | Tanimoto Sarina | Officer | Purchase | -- | 1.77M | -- | 1.77M |
| Nov 8, 22 | Tanimoto Sarina | Officer | Purchase | -- | 236.38K | -- | 236.38K |
| Nov 8, 22 | Tanimoto Sarina | Officer | Purchase | -- | 82.73K | -- | 82.73K |
| Nov 8, 22 | Lowenthal Richard E | CEO | Purchase | -- | 5.18M | -- | 5.18M |
| Nov 8, 22 | Lowenthal Richard E | CEO | Purchase | -- | 4.33M | -- | 4.33M |
| Nov 8, 22 | Lowenthal Richard E | CEO | Purchase | -- | 1.77M | -- | 1.77M |
| Nov 8, 22 | Lowenthal Richard E | CEO | Purchase | -- | 236.38K | -- | 236.38K |
| Nov 8, 22 | Lowenthal Richard E | CEO | Purchase | -- | 82.73K | -- | 82.73K |
| Nov 8, 22 | SAUNDERS BRENT L | CTO | Purchase | -- | 590.95K | -- | 590.95K |
| Nov 8, 22 | SAUNDERS BRENT L | CTO | Purchase | -- | 153.65K | -- | 153.65K |
| Nov 8, 22 | Kelly Michael | CTO | Purchase | -- | 118.19K | -- | 118.19K |
| Nov 8, 22 | Kelly Michael | CTO | Purchase | -- | 83.22K | -- | 83.22K |
| Nov 8, 22 | Kelly Michael | CTO | Purchase | -- | 70.42K | -- | 70.42K |
| Nov 8, 22 | Dadoo Rajeev | CTO | Purchase | -- | 3.01M | -- | 3.01M |
| Nov 8, 22 | Scott Kathleen D. | CFO | Purchase | -- | 827.33K | -- | 827.33K |
| Nov 8, 22 | SCHNEIDER PHILLIP M | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | SCHNEIDER PHILLIP M | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Shah Pratik | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Shah Pratik | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Karas Eric | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Karas Eric | Officer | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Lowenthal Richard E | CEO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Lowenthal Richard E | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Kelly Michael | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Kelly Michael | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Scott Kathleen D. | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Scott Kathleen D. | Officer | Sale | -- | -- | -- | -- |
| Nov 8, 22 | RA CAPITAL MANAGEMENT, L.P. | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | RA CAPITAL MANAGEMENT, L.P. | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | SAUNDERS BRENT L | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | SAUNDERS BRENT L | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Chakma Justin | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Chakma Justin | Officer | Sale | -- | -- | -- | -- |
| Nov 8, 22 | LEFF JONATHAN S | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | LEFF JONATHAN S | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Dadoo Rajeev | -- | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Dadoo Rajeev | CTO | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Tanimoto Sarina | Officer | Sale | -- | -- | -- | -- |
| Nov 8, 22 | Tanimoto Sarina | -- | Sale | -- | -- | -- | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | -- | -- | -- | 52.32K |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $1.27 | 18.27K | $23.20K | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $21.00 | 102.04K | $2.14M | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $3.15 | 79.26K | $249.67K | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $6.65 | 26.93K | $179.10K | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $1.68 | 35.41K | $59.48K | -- |
| Sep 2, 22 | Pepe Jeffrey C. | CEO | Sale | $4.85 | 28.50K | $138.22K | -- |
| Aug 5, 22 | Shawver Laura | CEO | Sale | $1.27 | 78.74K | $100.00K | 403.00K |
| Aug 5, 22 | Shawver Laura | CEO | Purchase | $1.27 | 78.74K | $100.00K | 254.24K |
| Jun 10, 22 | Thompson Peter A. | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | Thompson Peter A. | CTO | Purchase | $4.18 | 18.00K | $75.24K | 18.00K |
| Jun 10, 22 | ROOT JONATHAN D | CTO | Purchase | $4.18 | 18.00K | $75.24K | 18.00K |
| Jun 10, 22 | ROOT JONATHAN D | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | Powell Andrew Kenneth William | CTO | Purchase | $4.18 | 18.00K | $75.24K | 18.00K |
| Jun 10, 22 | Powell Andrew Kenneth William | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | Koehler Maria | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | Koehler Maria | CTO | Purchase | $4.18 | 18.00K | $75.24K | 18.00K |
| Jun 10, 22 | Islam Saqib | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | Islam Saqib | CTO | Purchase | $4.18 | 18.00K | $75.24K | 18.00K |
| Jun 10, 22 | HERSHBERG ROBERT | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| Jun 10, 22 | CAPPS VICKIE L | CTO | Purchase | -- | 18.00K | -- | 18.00K |
| May 2, 22 | Shawver Laura | CEO | Purchase | -- | 68.11K | -- | 175.50K |
| May 2, 22 | Shawver Laura | CEO | Purchase | $3.15 | 136.21K | $429.07K | 136.21K |
| May 2, 22 | Piazza Jonathan | CFO | Purchase | -- | 87.38K | -- | 87.38K |
| May 2, 22 | Odegard Valerie | President | Purchase | -- | 90.47K | -- | 90.47K |
| May 2, 22 | Hunder Naomi | Officer | Purchase | -- | 43.18K | -- | 54.43K |
| May 2, 22 | Hawkinson Russ | President | Purchase | -- | 28.34K | -- | 37.25K |
| Nov 15, 21 | ROOT JONATHAN D | CTO | Purchase | $8.85 | 2.01K | $17.82K | 2.36K |
| Mar 3, 21 | ROOT JONATHAN D | CTO | Purchase | $52.07 | 350 | $18.22K | 350 |
| Dec 8, 20 | Hawkinson Russ | President | Purchase | $21.00 | 200 | $4.20K | 200 |
| Feb 1, 22 | Hawkinson Russ | President | Purchase | $4.85 | 45.00K | $218.25K | 45.00K |
| Feb 1, 22 | Hawkinson Russ | President | Purchase | $4.85 | 28.50K | $138.22K | 28.50K |
| Feb 1, 22 | Hawkinson Russ | President | Purchase | -- | 7.50K | -- | 8.95K |
| Feb 1, 22 | Piazza Jonathan | CFO | Purchase | $4.85 | 67.50K | $327.38K | 67.50K |
| Feb 1, 22 | Piazza Jonathan | CFO | Purchase | $4.85 | 42.75K | $207.34K | 42.75K |
| Feb 1, 22 | Piazza Jonathan | CFO | Purchase | -- | 11.25K | -- | 25.53K |
| Feb 1, 22 | Hunder Naomi | Officer | Purchase | $4.85 | 67.50K | $327.38K | 67.50K |
| Feb 1, 22 | Hunder Naomi | Officer | Purchase | $4.85 | 42.75K | $207.34K | 42.75K |
| Feb 1, 22 | Hunder Naomi | Officer | Purchase | -- | 11.25K | -- | 11.25K |
| Feb 1, 22 | Shawver Laura | CEO | Purchase | $4.85 | 165.00K | $800.25K | 165.00K |
| Feb 1, 22 | Shawver Laura | CEO | Purchase | -- | 27.50K | -- | 107.39K |
| Feb 1, 22 | Shawver Laura | CEO | Purchase | $4.85 | 104.50K | $506.82K | 104.50K |
| Feb 1, 22 | Odegard Valerie | President | Purchase | $4.85 | 98.44K | $477.42K | 98.44K |
| Feb 1, 22 | Odegard Valerie | President | Purchase | $4.85 | 49.88K | $241.89K | 49.88K |
| Feb 1, 22 | Odegard Valerie | President | Purchase | -- | 16.41K | -- | 16.41K |
| Dec 13, 21 | ROOT JONATHAN D | CTO | Sale | -- | 105.01K | -- | -- |
| Jun 4, 21 | Thompson Peter A. | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Jun 4, 21 | ROOT JONATHAN D | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Jun 4, 21 | Powell Andrew Kenneth William | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Jun 4, 21 | Islam Saqib | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Jun 4, 21 | HERSHBERG ROBERT | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Jun 4, 21 | CAPPS VICKIE L | CTO | Purchase | $28.83 | 15.00K | $432.45K | 15.00K |
| Mar 12, 21 | Koehler Maria | CTO | Purchase | $55.51 | 25.00K | $1.39M | 25.00K |
| Mar 12, 21 | Koehler Maria | CTO | Sale | -- | -- | -- | -- |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Purchase | -- | 289.20K | -- | 2.07M |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Purchase | -- | 1.78M | -- | 1.78M |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Purchase | -- | 14.68K | -- | 105.01K |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Purchase | -- | 90.33K | -- | 90.33K |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Purchase | $21.00 | 47.62K | $1000.00K | 47.62K |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Sale | -- | 54.50K | -- | -- |
| Dec 8, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Sale | -- | 335.42K | -- | -- |
| Dec 8, 20 | CAPPS VICKIE L | CTO | Purchase | $21.00 | 9.52K | $199.98K | 61.58K |
| Dec 8, 20 | Hawkinson Russ | President | Purchase | $21.00 | 238 | $5.00K | 238 |
| Dec 8, 20 | Piazza Jonathan | CFO | Purchase | $21.00 | 11.90K | $249.98K | 11.90K |
| Dec 8, 20 | Schroeder Thilo | CTO | Purchase | -- | 425.06K | -- | 1.91M |
| Dec 8, 20 | Schroeder Thilo | CTO | Purchase | -- | 1.25M | -- | 1.48M |
| Dec 8, 20 | Schroeder Thilo | CTO | Purchase | $21.00 | 238.10K | $5.00M | 238.10K |
| Dec 8, 20 | Schroeder Thilo | CTO | Sale | -- | 4.63M | -- | -- |
| Dec 8, 20 | Schroeder Thilo | CTO | Sale | -- | 1.58M | -- | -- |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Purchase | -- | 289.20K | -- | 2.07M |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Purchase | -- | 1.78M | -- | 1.78M |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Purchase | -- | 14.68K | -- | 105.01K |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Purchase | $21.00 | 95.24K | $2.00M | 95.24K |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Purchase | -- | 90.33K | -- | 90.33K |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Sale | -- | 335.42K | -- | -- |
| Dec 8, 20 | ROOT JONATHAN D | CTO | Sale | -- | 54.50K | -- | -- |
| Dec 8, 20 | Thompson Peter A. | CTO | Purchase | -- | 1.06M | -- | 7.52M |
| Dec 8, 20 | Thompson Peter A. | CTO | Purchase | -- | 2.49M | -- | 6.46M |
| Dec 8, 20 | Thompson Peter A. | CTO | Purchase | -- | 3.46M | -- | 3.97M |
| Dec 8, 20 | Thompson Peter A. | CTO | Purchase | $21.00 | 952.38K | $20.00M | 952.38K |
| Dec 8, 20 | Thompson Peter A. | CTO | Purchase | $21.00 | 238.10K | $5.00M | 507.42K |
| Dec 8, 20 | Thompson Peter A. | CTO | Sale | -- | 9.26M | -- | -- |
| Dec 8, 20 | Thompson Peter A. | CTO | Sale | -- | 12.86M | -- | -- |
| Dec 8, 20 | Thompson Peter A. | CTO | Sale | -- | 3.92M | -- | -- |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Purchase | -- | 1.06M | -- | 7.52M |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Purchase | -- | 2.49M | -- | 6.46M |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Purchase | -- | 3.46M | -- | 3.97M |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Purchase | $21.00 | 952.38K | $20.00M | 952.38K |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Purchase | $21.00 | 238.10K | $5.00M | 507.42K |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 9.26M | -- | -- |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 3.92M | -- | -- |
| Dec 8, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 12.86M | -- | -- |
| Dec 8, 20 | Alexandria Venture Investments, LLC | 10 percent owner | Purchase | -- | 699.41K | -- | 699.41K |
| Dec 8, 20 | Alexandria Venture Investments, LLC | 10 percent owner | Sale | -- | 1.43M | -- | -- |
| Dec 8, 20 | Alexandria Venture Investments, LLC | 10 percent owner | Sale | -- | 1.17M | -- | -- |
| Dec 3, 20 | Thompson Peter A. | CTO | Purchase | $21.00 | 38.27K | $803.67K | 38.27K |
| Dec 3, 20 | Odegard Valerie | President | Purchase | $21.00 | 364.90K | $7.66M | 364.90K |
| Dec 3, 20 | Shawver Laura | CEO | Purchase | $21.00 | 562.63K | $11.82M | 562.63K |
| Dec 3, 20 | ROOT JONATHAN D | CTO | Purchase | $21.00 | 38.27K | $803.67K | 38.27K |
| Dec 3, 20 | Powell Andrew Kenneth William | CTO | Purchase | $21.00 | 21.01K | $441.19K | 21.01K |
| Dec 3, 20 | Piazza Jonathan | CFO | Purchase | $21.00 | 74.73K | $1.57M | 74.73K |
| Dec 3, 20 | Islam Saqib | CTO | Purchase | $21.00 | 69.75K | $1.46M | 69.75K |
| Dec 3, 20 | Hunder Naomi | Officer | Purchase | $21.00 | 231.07K | $4.85M | 231.07K |
| Dec 3, 20 | HERSHBERG ROBERT | CTO | Purchase | $21.00 | 73.25K | $1.54M | 73.25K |
| Dec 3, 20 | Hawkinson Russ | President | Purchase | $21.00 | 102.04K | $2.14M | 102.04K |
| Dec 3, 20 | CAPPS VICKIE L | CTO | Purchase | $21.00 | 38.41K | $806.50K | 38.41K |
| Dec 3, 20 | Odegard Valerie | President | Sale | $1.08 | 34.69K | $37.47K | -- |
| Dec 3, 20 | Powell Andrew Kenneth William | CTO | Sale | $10.25 | 52.05K | $533.54K | -- |
| Dec 3, 20 | CAPPS VICKIE L | CTO | Sale | -- | -- | -- | 52.05K |
| Dec 3, 20 | Alexandria Venture Investments, LLC | 10 percent owner | Sale | -- | 314.66K | -- | -- |
| Dec 3, 20 | Alexandria Venture Investments, LLC | 10 percent owner | Sale | -- | 384.75K | -- | -- |
| Dec 3, 20 | Odegard Valerie | President | Sale | $1.27 | 49.05K | $62.30K | -- |
| Dec 3, 20 | Odegard Valerie | President | Sale | $6.65 | 61.94K | $411.93K | -- |
| Dec 3, 20 | Odegard Valerie | President | Sale | $1.08 | 1.35K | $1.45K | -- |
| Dec 3, 20 | Odegard Valerie | President | Sale | $2.31 | 22.62K | $52.26K | -- |
| Dec 3, 20 | Schroeder Thilo | CTO | Sale | -- | 1.25M | -- | -- |
| Dec 3, 20 | Schroeder Thilo | CTO | Sale | -- | 425.06K | -- | -- |
| Dec 3, 20 | Islam Saqib | CTO | Sale | -- | -- | -- | 15.24K |
| Dec 3, 20 | Islam Saqib | CTO | Sale | $1.27 | 12.40K | $15.75K | -- |
| Dec 3, 20 | Hawkinson Russ | President | Sale | $6.65 | 26.93K | $179.10K | -- |
| Dec 3, 20 | Hawkinson Russ | President | Sale | $1.27 | 18.27K | $23.20K | -- |
| Dec 3, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Sale | -- | 14.68K | -- | -- |
| Dec 3, 20 | Presidio Management Group XII, L.L.C. | 10 percent owner | Sale | -- | 90.33K | -- | -- |
| Dec 3, 20 | HERSHBERG ROBERT | CTO | Sale | $1.27 | 14.21K | $18.05K | -- |
| Dec 3, 20 | HERSHBERG ROBERT | CTO | Sale | $2.31 | 38.10K | $88.01K | -- |
| Dec 3, 20 | Thompson Peter A. | CTO | Sale | -- | -- | -- | 269.32K |
| Dec 3, 20 | Thompson Peter A. | CTO | Sale | -- | 3.46M | -- | -- |
| Dec 3, 20 | Thompson Peter A. | CTO | Sale | -- | 1.06M | -- | -- |
| Dec 3, 20 | Thompson Peter A. | CTO | Sale | -- | 2.49M | -- | -- |
| Dec 3, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | -- | -- | 269.32K |
| Dec 3, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 3.46M | -- | -- |
| Dec 3, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 2.49M | -- | -- |
| Dec 3, 20 | ORBIMED ADVISORS LLC | CTO | Sale | -- | 1.06M | -- | -- |
| Dec 3, 20 | Hunder Naomi | Officer | Sale | $6.65 | 75.41K | $501.48K | -- |
| Dec 3, 20 | Hunder Naomi | Officer | Sale | $1.08 | 44.26K | $47.80K | -- |
| Dec 3, 20 | Hunder Naomi | Officer | Sale | $1.27 | 23.68K | $30.07K | -- |
| Dec 3, 20 | Shawver Laura | CEO | Sale | -- | -- | -- | 79.21K |
| Dec 3, 20 | Shawver Laura | CEO | Sale | $1.27 | 152.24K | $193.34K | -- |
| Dec 3, 20 | Shawver Laura | CEO | Sale | $6.65 | 222.19K | $1.48M | -- |
| Dec 3, 20 | Piazza Jonathan | CFO | Sale | $10.25 | 290.58K | $2.98M | -- |
| Dec 3, 20 | ROOT JONATHAN D | CTO | Sale | -- | 90.33K | -- | -- |
| Dec 3, 20 | ROOT JONATHAN D | CTO | Sale | -- | 14.68K | -- | -- |
| Dec 3, 20 | Powell Andrew Kenneth William | CTO | Sale | -- | -- | -- | -- |