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| Date | Insider | Title | Type | Price | Shares | Value | Owned After |
|---|---|---|---|---|---|---|---|
| Feb 3, 16 | ROEDER DOUGLAS A | CTO | Sale | $0.34 | 3.54M | $1.20M | -- |
| Feb 3, 16 | ROEDER DOUGLAS A | CTO | Sale | $0.34 | 149 | $50.66 | -- |
| Feb 3, 16 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | $0.34 | 3.54M | $1.20M | -- |
| Feb 3, 16 | Thomas Robert | CTO | Purchase | $2.43 | 16.52K | $40.15K | 106.64K |
| Feb 3, 16 | Thomas Robert | CTO | Sale | $5.62 | 7.14K | $40.15K | 99.49K |
| Feb 3, 16 | Thomas Robert | CTO | Sale | $0.34 | 9.38K | $3.19K | 90.12K |
| Feb 3, 16 | Thomas Robert | CTO | Sale | $0.34 | 90.12K | $30.64K | -- |
| Feb 3, 16 | Thomas Robert | CTO | Sale | $2.43 | 16.52K | $40.15K | -- |
| Feb 3, 16 | Moore Daniel Jeffrey | CTO | Purchase | $2.43 | 15.66K | $38.06K | 15.66K |
| Feb 3, 16 | Moore Daniel Jeffrey | CTO | Sale | $5.62 | 6.77K | $38.06K | 8.89K |
| Feb 3, 16 | Moore Daniel Jeffrey | CTO | Sale | $0.34 | 8.89K | $3.02K | -- |
| Feb 3, 16 | Moore Daniel Jeffrey | CTO | Sale | $2.43 | 15.66K | $38.06K | -- |
| Feb 3, 16 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | $0.34 | 3.94M | $1.34M | -- |
| Feb 3, 16 | Elting Kimberley A. | Officer | Purchase | $3.25 | 61.62K | $200.27K | 65.74K |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | $5.62 | 35.63K | $200.27K | 30.11K |
| Feb 3, 16 | Elting Kimberley A. | Officer | Purchase | -- | 15.00K | -- | 19.12K |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | $5.62 | 4.90K | $27.53K | 14.22K |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | $0.34 | 25.99K | $8.84K | 4.12K |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | $0.34 | 4.12K | $1.40K | -- |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | -- | 15.00K | -- | -- |
| Feb 3, 16 | Elting Kimberley A. | Officer | Sale | $3.25 | 61.62K | $200.27K | -- |
| Feb 3, 16 | Scopa James Paul | CTO | Sale | $0.34 | 1.78M | $604.08K | -- |
| May 22, 15 | DRANT RYAN D | CTO | Purchase | $5.85 | 10.00K | $58.50K | 10.00K |
| May 22, 15 | Moore Daniel Jeffrey | CTO | Purchase | $5.85 | 10.00K | $58.50K | 10.00K |
| May 22, 15 | Scopa James Paul | CTO | Purchase | $5.85 | 10.00K | $58.50K | 10.00K |
| May 22, 15 | Thomas Robert | CTO | Purchase | $5.85 | 10.00K | $58.50K | 10.00K |
| May 22, 15 | ROEDER DOUGLAS A | CTO | Purchase | $5.85 | 10.00K | $58.50K | 10.00K |
| Mar 2, 15 | Elting Kimberley A. | Officer | Purchase | $10.94 | 28.40K | $310.70K | 28.40K |
| Mar 2, 15 | Elting Kimberley A. | Officer | Purchase | -- | 15.00K | -- | 15.00K |
| Nov 29, 13 | Elting Kimberley A. | Officer | Purchase | $8.93 | 18.49K | $165.08K | 18.49K |
| Apr 22, 14 | Thomas Robert | CTO | Purchase | -- | 7.85K | -- | 86.84K |
| Apr 22, 14 | Thomas Robert | CTO | Purchase | -- | 41.45K | -- | 78.99K |
| Apr 22, 14 | Thomas Robert | CTO | Purchase | -- | 17.73K | -- | 37.54K |
| Apr 22, 14 | Thomas Robert | CTO | Purchase | -- | 11.54K | -- | 19.81K |
| Nov 1, 13 | Thomas Robert | CTO | Purchase | -- | 7.85K | -- | 7.85K |
| Apr 22, 14 | Thomas Robert | CTO | Purchase | $15.81 | 6.33K | $99.99K | 6.33K |
| Nov 29, 13 | Thomas Robert | CTO | Purchase | $8.93 | 4.93K | $44.02K | 4.93K |
| Apr 22, 14 | Thomas Robert | CTO | Sale | -- | 6.33K | -- | -- |
| Apr 22, 14 | Thomas Robert | CTO | Sale | -- | 41.45K | -- | -- |
| Apr 22, 14 | Thomas Robert | CTO | Sale | -- | 11.54K | -- | -- |
| Apr 22, 14 | Thomas Robert | CTO | Sale | -- | 7.85K | -- | -- |
| Apr 22, 14 | Thomas Robert | CTO | Sale | -- | 17.73K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | -- | 347.96K | -- | 3.54M |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | -- | 970.17K | -- | 3.19M |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | -- | 424.92K | -- | 2.22M |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | -- | 384.59K | -- | 1.79M |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | -- | 574.93K | -- | 1.41M |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | $12.00 | 833.33K | $10.00M | 833.33K |
| Nov 1, 13 | ROEDER DOUGLAS A | CTO | Purchase | -- | 347.96K | -- | 347.96K |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Purchase | $15.81 | 45.09K | $712.76K | 45.09K |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 384.59K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 574.93K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 970.17K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 45.09K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 424.92K | -- | -- |
| Apr 22, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 347.96K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 347.96K | -- | 3.54M |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 970.17K | -- | 3.19M |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 424.92K | -- | 2.22M |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 384.59K | -- | 1.79M |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 574.93K | -- | 1.41M |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | $12.00 | 833.33K | $10.00M | 833.33K |
| Nov 1, 13 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | -- | 347.96K | -- | 347.96K |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Purchase | $15.81 | 45.09K | $712.76K | 45.09K |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 45.09K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 424.92K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 347.96K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 574.93K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 384.59K | -- | -- |
| Apr 22, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 970.17K | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | -- | 411.23K | -- | 3.94M |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | -- | 1.24M | -- | 3.53M |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | -- | 531.76K | -- | 2.30M |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | -- | 383.25K | -- | 1.76M |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | -- | 797.21K | -- | 1.38M |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | $12.00 | 583.33K | $7.00M | 583.33K |
| Nov 1, 13 | DRANT RYAN D | CTO | Purchase | -- | 411.23K | -- | 411.23K |
| Apr 22, 14 | DRANT RYAN D | CTO | Purchase | $15.81 | 55.83K | $882.47K | 55.83K |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 55.83K | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 411.23K | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 1.24M | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 797.21K | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 383.25K | -- | -- |
| Apr 22, 14 | DRANT RYAN D | CTO | Sale | -- | 531.76K | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | -- | 411.23K | -- | 3.94M |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | -- | 1.24M | -- | 3.53M |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | -- | 531.76K | -- | 2.30M |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | -- | 383.25K | -- | 1.76M |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | -- | 797.21K | -- | 1.38M |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | $12.00 | 583.33K | $7.00M | 583.33K |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Purchase | $15.81 | 55.83K | $882.47K | 55.83K |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 1.24M | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 531.76K | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 55.83K | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 411.23K | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 797.21K | -- | -- |
| Apr 22, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 383.25K | -- | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | -- | 253.07K | -- | 1.78M |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | -- | 379.60K | -- | 1.52M |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | -- | 114.94K | -- | 1.14M |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | -- | 230.76K | -- | 1.03M |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | -- | 798.33K | -- | 798.33K |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Purchase | $15.81 | 37.37K | $590.66K | 37.37K |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | $0.39 | 1.52M | $590.68K | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 6.00M | -- | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 15.40M | -- | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 20.76M | -- | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 10.27M | -- | -- |
| Apr 22, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 2.95M | -- | -- |
| Nov 1, 13 | Scopa James Paul | CTO | Purchase | -- | 10.27M | -- | 10.27M |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | -- | 253.07K | -- | 1.78M |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | -- | 379.60K | -- | 1.52M |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | -- | 114.94K | -- | 1.14M |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | -- | 230.76K | -- | 1.03M |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | -- | 798.33K | -- | 798.33K |
| Apr 22, 14 | Scopa James Paul | CTO | Purchase | $15.81 | 37.37K | $590.66K | 37.37K |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | -- | 20.76M | -- | -- |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | -- | 2.95M | -- | -- |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | -- | 10.27M | -- | -- |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | -- | 15.40M | -- | -- |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | $0.39 | 1.52M | $590.68K | -- |
| Apr 22, 14 | Scopa James Paul | CTO | Sale | -- | 6.00M | -- | -- |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.00 | 340.43K | $4.09M | 593.81K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.00 | 297.07K | $3.56M | 518.19K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $11.97 | 94.52K | $1.13M | 324.52K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $11.97 | 75.48K | $903.13K | 261.14K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | -- | 253.38K | -- | 253.38K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.29 | 25.02K | $307.39K | 230.00K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | -- | 221.12K | -- | 221.12K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.00 | 118.15K | $1.42M | 204.98K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.29 | 19.98K | $245.47K | 185.66K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | $12.00 | 94.35K | $1.13M | 165.68K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | -- | 86.83K | -- | 86.83K |
| Apr 22, 14 | Flynn James E | 10% Owner | Purchase | -- | 71.33K | -- | 71.33K |
| Apr 22, 14 | Flynn James E | 10% Owner | Sale | -- | 253.38K | -- | -- |
| Apr 15, 14 | Elting Kimberley A. | Officer | Purchase | $12.00 | 35.30K | $423.60K | 35.30K |
| Apr 15, 14 | Flynn James E | 10% Owner | Sale | -- | 253.38K | -- | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | $15.81 | 45.09K | $712.76K | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 574.93K | -- | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 347.96K | -- | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 384.59K | -- | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 424.92K | -- | -- |
| Apr 15, 14 | Delphi Management Partners VIII, L.L.C. | 10 percent owner | Sale | -- | 970.17K | -- | -- |
| Nov 1, 14 | Elting Kimberley A. | Officer | Sale | $8.93 | 18.49K | $165.08K | -- |
| Mar 15, 14 | Elting Kimberley A. | Officer | Sale | $3.25 | 61.62K | $200.27K | -- |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | -- | -- | 8.28K |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | -- | -- | 3.28K |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | 11.54K | -- | -- |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | 17.73K | -- | -- |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | 41.45K | -- | -- |
| Jul 1, 12 | Thomas Robert | CTO | Sale | $2.43 | 12.32K | $29.95K | -- |
| Feb 28, 12 | Thomas Robert | CTO | Sale | $14.20 | 123 | $1.75K | -- |
| Apr 15, 14 | Thomas Robert | CTO | Sale | $15.81 | 6.33K | $99.99K | -- |
| Apr 15, 14 | Thomas Robert | CTO | Sale | -- | 7.85K | -- | -- |
| Dec 1, 13 | Thomas Robert | CTO | Sale | $8.93 | 4.93K | $44.02K | -- |
| Oct 7, 10 | Moore Daniel Jeffrey | CTO | Sale | $14.20 | 2.82K | $40.10K | -- |
| Dec 1, 13 | Moore Daniel Jeffrey | CTO | Sale | $8.93 | 4.93K | $44.02K | -- |
| Jul 1, 12 | Moore Daniel Jeffrey | CTO | Sale | $2.43 | 12.32K | $29.95K | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | -- | -- | 149 |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 574.93K | -- | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 424.92K | -- | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 384.59K | -- | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | $15.81 | 45.09K | $712.76K | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 970.17K | -- | -- |
| Apr 15, 14 | ROEDER DOUGLAS A | CTO | Sale | -- | 347.96K | -- | -- |
| Apr 15, 14 | Scopa James Paul | CTO | Sale | -- | 379.60K | -- | -- |
| Apr 15, 14 | Scopa James Paul | CTO | Sale | -- | 230.76K | -- | -- |
| Apr 15, 14 | Scopa James Paul | CTO | Sale | -- | 798.33K | -- | -- |
| Apr 15, 14 | Scopa James Paul | CTO | Sale | -- | 114.94K | -- | -- |
| Apr 15, 14 | Scopa James Paul | CTO | Sale | -- | 253.07K | -- | -- |
| Feb 12, 12 | Scopa James Paul | CTO | Sale | $0.39 | 1.52M | $590.68K | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | $15.81 | 55.83K | $882.47K | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | -- | 411.23K | -- | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | -- | 531.76K | -- | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | -- | 797.21K | -- | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | -- | 383.25K | -- | -- |
| Apr 15, 14 | DRANT RYAN D | CTO | Sale | -- | 1.24M | -- | -- |
| Apr 15, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 114.94K | -- | -- |
| Apr 15, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 798.33K | -- | -- |
| Apr 15, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 379.60K | -- | -- |
| Apr 15, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 230.76K | -- | -- |
| Apr 15, 14 | MPM BioVentures IV QP LP | 10 percent owner | Sale | -- | 253.07K | -- | -- |
| Feb 12, 12 | MPM BioVentures IV QP LP | 10 percent owner | Sale | $0.39 | 1.52M | $590.68K | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 531.76K | -- | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | $15.81 | 55.83K | $882.47K | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 411.23K | -- | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 1.24M | -- | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 383.25K | -- | -- |
| Apr 15, 14 | New Enterprise Associates 12, Limited Partnership | 10 percent owner | Sale | -- | 797.21K | -- | -- |