FULC
Next earnings: Aug 4, 2026 · Before open
Signal
Bearish Setup2
Price
1
Move-5.91%Selling pressure
Volume
1
Volume0.4× avgLight volume
Technical
1
RSIRSI 47Momentum negative
PRICE
Prev Close
7.11
Open
6.98
Day Range6.63 – 7.03
6.63
7.03
52W Range5.90 – 15.74
5.90
15.74
8% of range
VOLUME & SIZE
Avg Volume
1.1M
FUNDAMENTALS
P/E Ratio
-5.8x
Not profitable
EPS (TTM)
Div Yield
No dividend
Beta
1.19
Market-like
Performance
1D
-5.91%
5D
-2.76%
1M
-18.91%
3M
-37.06%
6M
-22.66%
YTD
-40.85%
1Y
+1.36%
Best: 1Y (+1.36%)Worst: YTD (-40.85%)
Quick Read
TrendInsufficient MA data
Momentum
BEARISH
revenue -100% YoY · thin 0% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 34.3 · FCF negative
Lean Bearish
Key MetricsTTM
Market Cap$362.01M
Revenue TTM$0.00
Net Income TTM-$76.12M
Free Cash Flow-$63.88M
Gross Margin0.0%
Net Margin0.0%
Operating Margin0.0%
Return on Equity-27.8%
Return on Assets-21.9%
Debt / Equity0.02
Current Ratio34.33
EPS TTM$-1.00
Alpha SignalsFull Analysis →
What Moves This Stock

Losmapimod commercial uptake metrics: new patient starts, persistence rates, and quarterly prescription volume trends in FSHD population

Clinical trial readouts for pipeline assets, particularly FTX-6058 (sickle cell disease) Phase 2 data and any new program initiations

Regulatory milestones including potential label expansions, international approvals for losmapimod, or IND filings for early-stage candidates

Cash runway extensions through financing events, partnerships, or milestone payments that affect dilution risk and operational continuity

Macro Sensitivity
Economic Cycle

low - Rare disease treatments demonstrate minimal correlation to GDP cycles as patients with debilitating genetic conditions require therapy regardless of economic conditions. FSHD is a progressive muscular dystrophy where treatment decisions are driven by medical necessity rather than discretionary spending. However, severe recessions could pressure payer reimbursement policies or patient out-of-pocket affordability for high-cost specialty drugs. The 2,752% revenue growth reflects product launch dynamics rather than economic sensitivity.

Interest Rates

Rising interest rates create moderate headwinds through two channels: (1) Higher discount rates compress NPV of future cash flows for pre-profitable biotech, disproportionately affecting valuation multiples for companies trading on long-term pipeline value rather than current earnings. (2) Increased financing costs for future capital raises, though current 17.7x current ratio suggests near-term liquidity is adequate. The 4% debt-to-equity ratio indicates minimal direct interest expense impact. Rate environment primarily affects equity valuation and cost of capital for future dilutive financings rather than operational economics.

Key Risks

Rare disease market size constraints: FSHD addressable population of 16,000-38,000 US patients creates revenue ceiling that may limit losmapimod peak sales to $300-500M range even at high penetration, requiring successful pipeline diversification for growth

Regulatory and reimbursement evolution for high-cost genetic therapies: increasing payer scrutiny of orphan drug pricing and potential legislative action on specialty pharmaceutical costs could compress margins or limit pricing flexibility

Clinical development risk concentration: pipeline heavily weighted toward genetic diseases with complex pathophysiology, where clinical trial failure rates exceed 90% and proof-of-concept requires expensive, lengthy studies

Investor Profile

growth - Attracts speculative biotech investors focused on clinical catalysts, rare disease commercial opportunity, and pipeline optionality rather than current profitability. The 182.8% one-year return and 60.5% six-month return reflect momentum-driven trading around clinical milestones and commercial launch dynamics. Negative margins and cash consumption preclude value or income investors. Typical holders include healthcare-focused hedge funds, biotech specialists, and retail investors seeking high-risk/high-reward exposure to rare disease therapeutics with near-term catalysts.

Watch on Earnings
Losmapimod quarterly prescription volume trends and year-over-year new patient starts in FSHD populationCash and equivalents balance relative to quarterly operating cash burn rate (runway calculation)Clinical trial enrollment rates and data readout timelines for FTX-6058 sickle cell programGross-to-net revenue adjustments indicating payer coverage breadth and pricing realization
Health Radar
3 strong3 concern
50/100
Liquidity
34.33Strong
Leverage
0.02Strong
Coverage
0.0xConcern
ROE
-27.8%Concern
ROIC
-25.5%Concern
Cash
$198MStrong
ANALYST COVERAGE15 analysts
BUY
+251.3%upside to target
L $10.00
Med $23.50consensus
H $25.00
Buy
1173%
Hold
320%
Sell
17%
11 Buy (73%)3 Hold (20%)1 Sell (7%)
Full report →
Stock Health
Composite Score
3 of 5 signals bullish
5/10
Technicals
RSI RangeRSI 47 — Bearish momentum
Volume
Volume FlowDistribution — institutional selling
Fundamentals
Last EarningsBeat estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 34.33 — healthy liquidity
Upcoming Events
EEarnings ReportMay 17, 2026
Tomorrow
DEx-Dividend DateAug 14, 2026
In 90 days
PDividend PaymentAug 31, 2026
In 107 days
Technicals
Technical SetupBEARISH
Technicals →

Trend

DowntrendDeath Cross · 50D trails 200D by 15.3%

-10.2% vs SMA 50 · -23.9% vs SMA 200

Momentum

RSI47.3
Neutral territory
MACD-0.17
Below zero — bearish pulse · expanding
Market Position
Price Levels
52W High
$15.74+135.3%
EMA 200
$8.20+22.6%
EMA 50
$7.71+15.3%
Current
$6.69
52W Low
$5.90-11.7%
52-Week RangeNear 52-week low
$5.908th %ile$15.74
Squeeze SetupVolume-based
Distribution Pressure

Distribution pattern detected. More selling days than accumulation over the past 20 sessions. Not a conducive environment for a squeeze.

20-Day Money Flow
Acc days:0
Dist days:2
Edge:+2 dist
Volume Context
Avg Vol (50D)952K
Recent Vol (5D)
540K-43%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 10 analysts
Analyst revisions:Revenue↑ Revised Up

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$28.1M
$28.1M$28.1M
-$1.16
±4%
High10
FY2026(current)
$311890
$311890$311890
-98.9%-$1.16
±16%
High10
FY2027
$361.2M
$361.2M$361.2M
+115722.9%-$1.32
±30%
High9
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryFULC
Last 8Q
+885.2%avg beat
Beat 5 of 8 quartersMissed 2 Estimates falling
+7060%
Q3'24
+13%
Q4'24
-11%
Q1'25
+3%
Q2'25
+3%
Q3'25
-7%
Q4'25
Q1'26
+19%
Q2'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
Cantor FitzgeraldNeutral → Overweight
May 14
UPGRADE
H.C. WainwrightHold → Neutral
Sep 13
DOWNGRADE
RBC CapitalOutperform → Sector Perform
Sep 12
DOWNGRADE
Bank of America Sec…Neutral → Underperform
Sep 12
DOWNGRADE
Cantor FitzgeraldOverweight → Neutral
Sep 12
DOWNGRADE
Bank of America Sec…Underperform → Neutral
Sep 9
UPGRADE
H.C. WainwrightBuy → Hold
Aug 23
UPGRADE
DaiwaNeutral
Aug 22
DOWNGRADE
OTR GlobalMixed
Aug 22
DOWNGRADE
Compass PointBuy
Aug 22
UPGRADE
Credit SuisseOutperform → Neutral
Mar 10
DOWNGRADE
Morgan StanleyOverweight → Equal-Weight
Feb 28
DOWNGRADE
Insider Activity
SEC Filings →
0 Buys/6 SellsNet Selling
Gould Robert JDir
$163K
Jan 2
SELL
Gould Robert JDir
$161K
Feb 2
SELL
Gould Robert JDir
$178K
Jan 2
SELL
Oltmans Curtis GaleChief Legal Of…
$45K
Dec 15
SELL
Ra Capital Manageme…10 Percent Own…
$18.4M
Dec 8
SELL
Ra Capital Manageme…10 Percent Own…
$38.6M
Dec 8
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
SUVRETTA CAPITAL MANAGEMENT, LLC
6.6M
2
RA CAPITAL MANAGEMENT, L.P.
6.1M
3
BlackRock, Inc.
5.4M
4
TCG Crossover Management, LLC
5.3M
5
BRAIDWELL LP
3.1M
6
Nantahala Capital Management, LLC
3.1M
7
Siren, L.L.C.
2.4M
8
First Turn Management, LLC
2.3M
News & Activity

FULC News

About

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum's proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression. The company has advanced losmapimod to Phase 2 clinical development for the treatment of facioscapulohumeral muscular dystrophy (FSHD). Fulcrum has also advanced FTX-6058, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and beta thalassemia into Phase 1 clinical development.

Industry
Medicinal and Botanical Manufacturing
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
FULC
$6.69-5.91%$362M-10000.0%1500
$66.13-5.07%$13.0B+12626.1%-14525.8%1500
$94.92-3.79%$12.6B+3288.2%-4239.0%1500
$523.69-3.00%$12.1B+43205.3%-3008.0%1500
$227.72-1.30%$11.7B+6554.5%-2868.8%1500
$57.90-0.86%$11.2B50.3+1459.3%147.7%1500
$76.67-3.79%$10.8B+2325815.3%-19.7%1500
Sector avg-3.39%50.3+340421.2%-4085.6%1500