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Today's biggest gainers and losers
| Holder | Shares | Date | Change | % Held |
|---|---|---|---|---|
| FMR LLC | 4.13M | Jun 30, 26 | -- | 11.13% |
| BVF INC/IL | 2.75M | Jun 30, 26 | -- | 7.40% |
| Fairmount Funds Management LLC | 2.75M | Jun 30, 26 | -- | 7.40% |
| VR Adviser, LLC | 2.13M | Jun 30, 26 | -- | 5.74% |
| Logos Global Management LP | 1.90M | Jun 30, 26 | +1.42M | 5.12% |
| FCPM III SERVICES B.V. | 1.68M | Jun 30, 26 | -- | 4.52% |
| BALYASNY ASSET MANAGEMENT L.P. | 1.66M | Jun 30, 26 | +152.88K | 4.48% |
| Vestal Point Capital, LP | 1.63M | Jun 30, 26 | +130.00K | 4.39% |
| Opaleye Management Inc. | 1.32M | Jun 30, 26 | +6.74K | 3.55% |
| BlackRock, Inc. | 1.27M | Jun 30, 26 | +1.16M | 3.42% |
| TANG CAPITAL MANAGEMENT LLC | 1.16M | Jun 30, 26 | -- | 3.12% |
| VANGUARD CAPITAL MANAGEMENT LLC | 767.75K | Jun 30, 26 | -33.64K | 2.07% |
| MILLENNIUM MANAGEMENT LLC | 403.86K | Jun 30, 26 | +80.31K | 1.09% |
| GEODE CAPITAL MANAGEMENT, LLC | 384.58K | Jun 30, 26 | +280.36K | 1.04% |
| JENNISON ASSOCIATES LLC | 378.51K | Jun 30, 26 | +225.53K | 1.02% |
| RTW INVESTMENTS, LP | 372.86K | Jun 30, 26 | -- | 1.00% |
| NEXTBio Capital Management LP | 372.86K | Jun 30, 26 | -- | 1.00% |
| Remedium Capital Partners, LLC | 361.25K | Jun 30, 26 | +361.25K | 0.97% |
| STATE STREET CORP | 315.59K | Jun 30, 26 | +276.52K | 0.85% |
| AMERIPRISE FINANCIAL INC | 302.57K | Jun 30, 26 | +302.57K | 0.81% |
| Point72 Asset Management, L.P. | 300.00K | Jun 30, 26 | -- | 0.81% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 275.58K | Jun 30, 26 | -27.97K | 0.74% |
| MARSHALL WACE, LLP | 214.30K | Jun 30, 26 | +13.52K | 0.58% |
| PERCEPTIVE ADVISORS LLC | 206.94K | Jun 30, 26 | -- | 0.56% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 188.80K | Jun 30, 26 | +188.80K | 0.51% |
| TWO SIGMA INVESTMENTS, LP | 186.87K | Jun 30, 26 | +71.05K | 0.50% |
| StemPoint Capital LP | 182.38K | Jun 30, 26 | +182.38K | 0.49% |
| UBS Group AG | 175.18K | Jun 30, 26 | +92.48K | 0.47% |
| NORTHERN TRUST CORP | 138.78K | Jun 30, 26 | +121.55K | 0.37% |
| Exome Asset Management LLC | 127.77K | Jun 30, 26 | -25.42K | 0.34% |
| SECTORAL ASSET MANAGEMENT INC | 121.30K | Jun 30, 26 | +121.30K | 0.33% |
| Woodline Partners LP | 94.49K | Jun 30, 26 | +20.49K | 0.25% |
| VANGUARD FIDUCIARY TRUST CO | 75.22K | Jun 30, 26 | +25.80K | 0.20% |
| Burkehill Global Management, LP | 74.00K | Jun 30, 26 | -- | 0.20% |
| Blackstone Inc. | 62.65K | Jun 30, 26 | +62.65K | 0.17% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 59.10K | Jun 30, 26 | -71.40K | 0.16% |
| Y-Intercept (Hong Kong) Ltd | 50.82K | Jun 30, 26 | +50.82K | 0.14% |
| Sixth Street Partners Management Company, L.P. | 50.26K | Jun 30, 26 | +50.26K | 0.14% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50.26K | Jun 30, 26 | +50.26K | 0.14% |
| Nuveen, LLC | 47.63K | Jun 30, 26 | +47.63K | 0.13% |
| Bank of New York Mellon Corp | 45.78K | Jun 30, 26 | +45.78K | 0.12% |
| Stonepine Capital Management, LLC | 40.00K | Jun 30, 26 | -45.00K | 0.11% |
| BANK OF AMERICA CORP /DE/ | 25.82K | Jun 30, 26 | -3.46K | 0.07% |
| RHUMBLINE ADVISERS | 25.49K | Jun 30, 26 | +25.49K | 0.07% |
| MOORE CAPITAL MANAGEMENT, LP | 25.00K | Jun 30, 26 | -- | 0.07% |
| Squarepoint Ops LLC | 24.17K | Jun 30, 26 | +24.17K | 0.07% |
| AMERICAN CENTURY COMPANIES INC | 22.80K | Jun 30, 26 | +22.80K | 0.06% |
| WELLS FARGO & COMPANY/MN | 19.70K | Jun 30, 26 | +19.70K | 0.05% |
| ADAR1 Capital Management, LLC | 18.27K | Jun 30, 26 | -32.00K | 0.05% |
| Virtus Investment Advisers, Inc. | 18.26K | Jun 30, 26 | +18.26K | 0.05% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17.75K | Jun 30, 26 | -7.15K | 0.05% |
| MORGAN STANLEY | 17.70K | Jun 30, 26 | -879 | 0.05% |
| WELLINGTON MANAGEMENT GROUP LLP | 14.60K | Jun 30, 26 | +14.60K | 0.04% |
| BANK OF MONTREAL /CAN/ | 13.77K | Jun 30, 26 | +13.77K | 0.04% |
| MetLife Investment Management, LLC | 12.78K | Jun 30, 26 | +12.78K | 0.03% |
| Invesco Ltd. | 11.73K | Jun 30, 26 | +11.73K | 0.03% |
| Persistent Asset Partners Ltd | 10.97K | Jun 30, 26 | +10.97K | 0.03% |
| XTX Topco Ltd | 10.56K | Jun 30, 26 | +10.56K | 0.03% |
| CITIGROUP INC | 10.14K | Jun 30, 26 | -10.03K | 0.03% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.90K | Jun 30, 26 | +9.90K | 0.03% |
| JPMORGAN CHASE & CO | 9.02K | Jun 30, 26 | -31.98K | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.60K | Jun 30, 26 | +7.60K | 0.02% |
| Police & Firemen's Retirement System of New Jersey | 6.37K | Jun 30, 26 | +6.37K | 0.02% |
| BARCLAYS PLC | 4.46K | Jun 30, 26 | -25.73K | 0.01% |
| BNP PARIBAS ARBITRAGE, SNC | 3.30K | Jun 30, 26 | -12.39K | 0.01% |
| Vanguard Global Advisers, LLC | 2.71K | Jun 30, 26 | -755 | 0.01% |
| Legal & General Group Plc | 2.10K | Jun 30, 26 | +2.10K | 0.01% |
| Tower Research Capital LLC (TRC) | 1.76K | Jun 30, 26 | +1.76K | 0.00% |
| Russell Investments Group, Ltd. | 1.73K | Jun 30, 26 | +1.73K | 0.00% |
| ROYAL BANK OF CANADA | 681 | Jun 30, 26 | +630 | 0.00% |
| US BANCORP \DE\ | 403 | Jun 30, 26 | +403 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 297 | Jun 30, 26 | +297 | 0.00% |
| Parallel Advisors, LLC | 264 | Jun 30, 26 | -- | 0.00% |
| Allworth Financial LP | 161 | Jun 30, 26 | -- | 0.00% |
| Sterling Capital Management LLC | 76 | Jun 30, 26 | +76 | 0.00% |
| SBI Securities Co., Ltd. | 68 | Jun 30, 26 | -- | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | 50 | Jun 30, 26 | +50 | 0.00% |
| Fortitude Family Office, LLC | 40 | Jun 30, 26 | -- | 0.00% |
| Quarry LP | 29 | Jun 30, 26 | +29 | 0.00% |
| ADVISOR GROUP HOLDINGS, INC. | 26 | Jun 30, 26 | -- | 0.00% |
| Caitong International Asset Management Co., Ltd | 21 | Jun 30, 26 | +17 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | 3 | Jun 30, 26 | +3 | 0.00% |
| Hudson Bay Capital Management LP | -- | Jun 30, 26 | -88.87K | -- |
| OMERS ADMINISTRATION Corp | -- | Jun 30, 26 | -17.80K | -- |
| ALGERT GLOBAL LLC | -- | Jun 30, 26 | -13.81K | -- |
| RENAISSANCE TECHNOLOGIES LLC | -- | Jun 30, 26 | -24.26K | -- |
| Cannon Global Investment Management, LLC | -- | Jun 30, 26 | -10.20K | -- |
| Alyeska Investment Group, L.P. | -- | Jun 30, 26 | -264.00K | -- |
| GOLDMAN SACHS GROUP INC | -- | Jun 30, 26 | -228.47K | -- |
| Brevan Howard Capital Management LP | -- | Jun 30, 26 | -19.53K | -- |
| Lighthouse Investment Partners, LLC | -- | Jun 30, 26 | -25.00K | -- |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | -- | Jun 30, 26 | -213.63K | -- |
| Verdad Advisers, LP | -- | Jun 30, 26 | -12.75K | -- |
| Deep Track Capital, LP | -- | Jun 30, 26 | -453.69K | -- |
| VANGUARD GROUP INC | 557.51K | Dec 31, 25 | -100.39K | 1.50% |
| TWO SIGMA ADVISERS, LP | 32.50K | Dec 31, 25 | +32.50K | 0.09% |
| American Portfolios Advisors | 215 | Sep 30, 22 | -- | 0.00% |
| Johnson & Johnson Innovation - JJDC, Inc. | 66.95K | Jun 30, 21 | -- | 0.18% |
| PA Capital LLC | 20.14K | Sep 30, 20 | +3.90K | 0.05% |
| Alambic Investment Management, L.P. | 17.68K | Sep 30, 20 | +17.68K | 0.05% |
| TIAA CREF INVESTMENT MANAGEMENT LLC | 24.59K | Mar 31, 19 | +7.96K | 0.07% |
| TEACHERS ADVISORS, LLC | 22.74K | Mar 31, 19 | -- | 0.06% |
| Requisite Energy Fund I LP | 32.50K | Dec 31, 18 | +32.50K | 0.09% |
| Edge Advisors, LLC | -- | Jun 30, 18 | -47 | -- |
| Iguana Healthcare Management, LLC | 100.00K | Mar 31, 18 | +100.00K | 0.27% |
| FNY Partners Fund LP | -- | Mar 31, 18 | -1.00K | -- |
| Virtu KCG Holdings LLC | 22.18K | Jun 30, 17 | +22.18K | 0.06% |
