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Today's biggest gainers and losers
| Holder | Shares | Date | Change | % Held |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 7.81M | Jun 30, 26 | +7.81M | 16.72% |
| Novo Holdings A/S | 4.18M | Jun 30, 26 | +4.18M | 8.95% |
| FMR LLC | 3.70M | Jun 30, 26 | +3.70M | 7.92% |
| Capital International Investors | 3.60M | Jun 30, 26 | +3.60M | 7.72% |
| Deep Track Capital, LP | 3.60M | Jun 30, 26 | +3.60M | 7.71% |
| Siren, L.L.C. | 2.09M | Jun 30, 26 | +2.09M | 4.47% |
| Avoro Capital Advisors LLC | 1.93M | Jun 30, 26 | +1.93M | 4.12% |
| Bain Capital Life Sciences Investors, LLC | 1.65M | Jun 30, 26 | +1.65M | 3.53% |
| JPMORGAN CHASE & CO | 1.15M | Jun 30, 26 | +1.15M | 2.47% |
| VANGUARD CAPITAL MANAGEMENT LLC | 780.76K | Jun 30, 26 | +780.76K | 1.67% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 746.04K | Jun 30, 26 | +746.04K | 1.60% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 715.79K | Jun 30, 26 | +715.79K | 1.53% |
| Rock Springs Capital Management LP | 575.43K | Jun 30, 26 | +575.43K | 1.23% |
| Bellevue Group AG | 550.00K | Jun 30, 26 | +550.00K | 1.18% |
| CITADEL ADVISORS LLC | 523.45K | Jun 30, 26 | +523.45K | 1.12% |
| BlackRock, Inc. | 283.83K | Jun 30, 26 | +283.83K | 0.61% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 275.00K | Jun 30, 26 | +275.00K | 0.59% |
| ExodusPoint Capital Management, LP | 218.29K | Jun 30, 26 | +218.29K | 0.47% |
| GEODE CAPITAL MANAGEMENT, LLC | 211.80K | Jun 30, 26 | +211.80K | 0.45% |
| BRAIDWELL LP | 160.00K | Jun 30, 26 | +160.00K | 0.34% |
| MARSHALL WACE, LLP | 154.67K | Jun 30, 26 | +154.67K | 0.33% |
| Woodline Partners LP | 150.04K | Jun 30, 26 | +150.04K | 0.32% |
| Affinity Asset Advisors, LLC | 138.03K | Jun 30, 26 | +138.03K | 0.30% |
| Ensign Peak Advisors, Inc | 115.39K | Jun 30, 26 | +115.39K | 0.25% |
| VANGUARD FIDUCIARY TRUST CO | 112.50K | Jun 30, 26 | +112.50K | 0.24% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 108.24K | Jun 30, 26 | +108.24K | 0.23% |
| Sixth Street Partners Management Company, L.P. | 108.24K | Jun 30, 26 | +108.24K | 0.23% |
| AMERIPRISE FINANCIAL INC | 81.93K | Jun 30, 26 | +81.93K | 0.18% |
| STATE STREET CORP | 76.90K | Jun 30, 26 | +76.90K | 0.16% |
| Burkehill Global Management, LP | 75.00K | Jun 30, 26 | +75.00K | 0.16% |
| abrdn plc | 52.12K | Jun 30, 26 | +52.12K | 0.11% |
| Opaleye Management Inc. | 47.65K | Jun 30, 26 | +47.65K | 0.10% |
| UBS Group AG | 47.35K | Jun 30, 26 | +47.35K | 0.10% |
| Parkman Healthcare Partners LLC | 45.00K | Jun 30, 26 | +45.00K | 0.10% |
| NORTHERN TRUST CORP | 40.49K | Jun 30, 26 | +40.49K | 0.09% |
| Ghisallo Capital Management LLC | 40.00K | Jun 30, 26 | +40.00K | 0.09% |
| TD ASSET MANAGEMENT INC | 33.10K | Jun 30, 26 | +33.10K | 0.07% |
| SEVEN GRAND MANAGERS, LLC | 30.00K | Jun 30, 26 | +30.00K | 0.06% |
| SOROS FUND MANAGEMENT LLC | 25.00K | Jun 30, 26 | +25.00K | 0.05% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18.72K | Jun 30, 26 | +18.72K | 0.04% |
| GSA CAPITAL PARTNERS LLP | 17.66K | Jun 30, 26 | +17.66K | 0.04% |
| XTX Topco Ltd | 17.39K | Jun 30, 26 | +17.39K | 0.04% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 13.18K | Jun 30, 26 | +13.18K | 0.03% |
| Hudson Bay Capital Management LP | 12.20K | Jun 30, 26 | +12.20K | 0.03% |
| Schonfeld Strategic Advisors LLC | 10.81K | Jun 30, 26 | +10.81K | 0.02% |
| Weiss Asset Management LP | 10.00K | Jun 30, 26 | +10.00K | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 8.17K | Jun 30, 26 | +8.17K | 0.02% |
| Vanguard Global Advisers, LLC | 7.62K | Jun 30, 26 | +7.62K | 0.02% |
| Squarepoint Ops LLC | 6.25K | Jun 30, 26 | +6.25K | 0.01% |
| TWO SIGMA INVESTMENTS, LP | 5.68K | Jun 30, 26 | +5.68K | 0.01% |
| MORGAN STANLEY | 4.08K | Jun 30, 26 | +4.08K | 0.01% |
| China Universal Asset Management Co., Ltd. | 3.60K | Jun 30, 26 | +3.60K | 0.01% |
| CITIGROUP INC | 2.10K | Jun 30, 26 | +2.10K | 0.00% |
| BARCLAYS PLC | 1.01K | Jun 30, 26 | +1.01K | 0.00% |
| ROYAL BANK OF CANADA | 248 | Jun 30, 26 | +248 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | 3 | Jun 30, 26 | +3 | 0.00% |
| Tower Research Capital LLC (TRC) | 1 | Jun 30, 26 | +1 | 0.00% |
