EWTX
Next earnings: Aug 6, 2026 · Before open
Signal
Mixed11
Price
1
Move-2.71%Negative session
Volume
1
Volume1.0× avgNormal activity
Technical
1
RSIRSI 52Momentum positive
PRICE
Prev Close
34.01
Open
33.81
Day Range32.76 – 33.95
32.76
33.95
52W Range12.15 – 39.96
12.15
39.96
75% of range
VOLUME & SIZE
Avg Volume
1.0M
FUNDAMENTALS
P/E Ratio
-19.9x
Not profitable
EPS (TTM)
Div Yield
No dividend
Beta
1.42
Market-like
Performance
1D
-2.71%
5D
-6.39%
1M
-1.81%
3M
+10.26%
6M
+45.45%
YTD
+33.32%
1Y
+129.00%
Best: 1Y (+129.00%)Worst: 5D (-6.39%)
Quick Read
TrendInsufficient MA data
Momentum
BEARISH
thin 0% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 22.6 · FCF negative
Neutral
Key MetricsTTM
Market Cap$3.56B
Revenue TTM$0.00
Net Income TTM-$176.01M
Free Cash Flow-$148.71M
Gross Margin0.0%
Net Margin0.0%
Operating Margin0.0%
Return on Equity-32.5%
Return on Assets-33.9%
Debt / Equity0.01
Current Ratio22.61
EPS TTM$-1.64
Alpha SignalsFull Analysis →
What Moves This Stock

EDG-5506 Phase 3 CANYON trial data readouts in DMD patients (primary endpoint: change in left ventricular ejection fraction)

FDA regulatory milestone announcements (IND approvals, Breakthrough Therapy designation, NDA filing acceptance)

Partnership or licensing deals for pipeline assets, particularly EDG-7500 in hypertrophic cardiomyopathy

Capital raises and cash runway extensions (dilution concerns versus funding security trade-off)

Macro Sensitivity
Economic Cycle

low - Rare disease drug demand is highly inelastic to economic cycles due to life-threatening nature of conditions and insurance/government reimbursement coverage. Clinical trial timelines proceed independently of GDP fluctuations. However, capital markets access for funding is cyclically sensitive, affecting ability to finance operations during risk-off periods.

Interest Rates

Rising rates negatively impact valuation through higher discount rates applied to distant cash flows (DCF models heavily weight post-2028 revenue). Higher rates also increase opportunity cost of holding non-earning biotech versus fixed income, compressing multiples. Financing costs minimal given low debt (0.01 D/E ratio), but equity capital becomes more expensive in high-rate environments as investors demand higher returns. The 115% six-month return suggests recent rate stabilization/cuts have benefited valuation.

Key Risks

Binary clinical trial risk: Phase 3 failure of EDG-5506 would eliminate 80%+ of company value given single-asset focus as of early 2026

Regulatory approval uncertainty: FDA may require additional safety studies or impose restrictive labeling limiting addressable patient population

Reimbursement pressure: Payers increasingly scrutinizing ultra-orphan drug pricing, potentially capping revenue below $300K/patient assumptions

Investor Profile

growth - Pure clinical-stage speculation attracting biotech-focused hedge funds, venture crossover funds, and retail momentum traders. The 115% six-month return indicates strong momentum investor participation. No dividends or value characteristics; entirely dependent on binary clinical/regulatory catalysts. Institutional ownership likely concentrated among specialized healthcare funds (RA Capital, Perceptive Advisors, Boxer Capital) willing to underwrite binary risk for 3-5x return potential on approval.

Watch on Earnings
EDG-5506 Phase 3 trial enrollment pace and data readout timing (expected mid-2026 interim analysis)FDA Breakthrough Therapy or Fast Track designation status changesCash and equivalents balance versus quarterly burn rate (runway calculation)Competitor clinical trial results in DMD space (Sarepta, Pfizer, Entrada)
Health Radar
2 strong1 watch3 concern
40/100
Liquidity
22.61Strong
Leverage
0.01Strong
Coverage
0.0xConcern
ROE
-32.5%Concern
ROIC
-40.2%Concern
Cash
$61MWatch
ANALYST COVERAGE8 analysts
BUY
+37.5%upside to target
L $25.00
Med $45.50consensus
H $52.00
Buy
788%
Sell
113%
7 Buy (88%)0 Hold (0%)1 Sell (12%)
Full report →
Stock Health
Composite Score
4 of 5 signals bullish
7/10
Technicals
RSI RangeRSI 52 — Bullish momentum
Volume
Volume FlowDistribution — institutional selling
Fundamentals
Last EarningsBeat estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 22.61 — healthy liquidity
Upcoming Events
EEarnings ReportMay 17, 2026
Tomorrow
DEx-Dividend DateAug 14, 2026
In 90 days
PDividend PaymentAug 20, 2026
In 96 days
Technicals
Technical SetupBULLISH
Technicals →

Trend

UptrendGolden Cross · 50D leads 200D by 35.8%

+3.1% vs SMA 50 · +40.0% vs SMA 200

Momentum

RSI52.3
Neutral territory
MACD+0.64
Above zero — bullish momentum · compressing
Market Position
Price Levels
52W High
$39.96+20.8%
Current
$33.09
EMA 50
$32.26-2.5%
EMA 200
$24.43-26.2%
52W Low
$12.15-63.3%
52-Week RangeNear 52-week high
$12.1575th %ile$39.96
Squeeze SetupVolume-based
Distribution Pressure

Distribution pattern detected. More selling days than accumulation over the past 20 sessions. Not a conducive environment for a squeeze.

20-Day Money Flow
Acc days:3
Dist days:6
Edge:+3 dist
Volume Context
Avg Vol (50D)1.1M
Recent Vol (5D)
1.0M-2%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 9 analysts
Analyst revisions:EPS↑ Revised Up

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$0-$1.60
±3%
High9
FY2026(current)
$2.3M
$1.4M$3.8M
-$2.06
±15%
High9
FY2027
$14.5M
$2.4M$36.5M
+536.5%-$2.28
±19%
High9
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryEWTX
Last 8Q
+3.2%avg beat
Beat 6 of 8 quartersMissed 2 Estimates falling
+6%
Q3'24
+3%
Q4'24
-8%
Q1'25
+4%
Q2'25
+19%
Q3'25
+3%
Q4'25
-9%
Q1'26
+8%
Q2'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
ScotiabankOutperform → Sector Perform
Apr 3
DOWNGRADE
Insider Activity
SEC Filings →
0 Buys/6 SellsNet Selling
NET SELLERS$0 bought · $2.1M sold · 30d window
Donovan Joanne M.CMO
$1.9M
May 5
SELL
Donovan Joanne M.CMO
$164K
May 4
SELL
Donovan Joanne M.CMO
$926K
Apr 1
SELL
Donovan Joanne M.CMO
$685K
Mar 31
SELL
Donovan Joanne M.CMO
$298K
Mar 27
SELL
Donovan Joanne M.CMO
$209K
Mar 27
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
ORBIMED ADVISORS LLC
15.5M
2
RA CAPITAL MANAGEMENT, L.P.
10.4M
3
Paradigm Biocapital Advisors LP
7.4M
4
BAKER BROS. ADVISORS LP
6.6M
5
BlackRock, Inc.
6.5M
6
JANUS HENDERSON GROUP PLC
5.9M
7
Novo Holdings A/S
5.3M
8
DRIEHAUS CAPITAL MANAGEMENT LLC
4.5M
News & Activity

EWTX News

19 articles · 4h ago

About

Edgewise Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of innovative treatments for severe, rare muscle disorders for which there is significant unmet medical need. Guided by its holistic drug discovery approach to targeting the muscle as an organ, Edgewise has combined its foundational expertise in muscle biology and small molecule engineering to build its proprietary, muscle focused drug discovery platform. Edgewise’s platform utilizes custom-built high throughput and translatable systems that measure integrated muscle function in whole organ extracts to identify small molecule precision medicines regulating key proteins in muscle tissue, initially focused on addressing rare neuromuscular and cardiac diseases.

Industry
Medicinal and Botanical Manufacturing
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
EWTX
$33.09-2.71%$3.6B1500
$66.13-5.07%$13.0B+12626.1%-14525.8%1500
$94.92-3.79%$12.6B+3288.2%-4239.0%1500
$523.69-3.00%$12.1B+43205.3%-3008.0%1500
$227.72-1.30%$11.7B+6554.5%-2868.8%1500
$57.90-0.86%$11.2B50.3+1459.3%147.7%1500
$76.67-3.79%$10.8B+2325815.3%-19.7%1500
Sector avg-2.93%50.3+398824.8%-4085.6%1500