| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $16.15 | 27.50K | $444.12K | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | -- | 8.25K | -- | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $9.20 | 61.45K | $565.34K | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $10.37 | 29.50K | $305.92K | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $14.09 | 32.50K | $457.93K | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $25.00 | 3.79K | $94.88K | -- |
| Mar 1, 13 | KELLERMAN DONALD J | Officer | Sale | $16.19 | 55.00K | $890.45K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $25.00 | 2.00K | $50.00K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $8.98 | 30.00K | $269.40K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $3.18 | 7.50K | $23.85K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $16.47 | 7.50K | $123.52K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $14.77 | 7.50K | $110.78K | -- |
| Mar 1, 13 | WARD SCOTT R | CTO | Sale | $11.69 | 10.00K | $116.90K | -- |
| Mar 1, 13 | HENWOOD GERALDINE | CTO | Sale | $16.47 | 7.50K | $123.52K | -- |
| Mar 1, 13 | HENWOOD GERALDINE | CTO | Sale | $11.69 | 5.00K | $58.45K | -- |
| Mar 1, 13 | HENWOOD GERALDINE | CTO | Sale | $14.77 | 7.50K | $110.78K | -- |
| Feb 28, 13 | HENWOOD GERALDINE | CTO | Purchase | $12.19 | 7.50K | $91.42K | 10.00K |
| Feb 28, 13 | HENWOOD GERALDINE | CTO | Sale | $11.69 | 2.50K | $29.23K | 5.00K |
| Feb 28, 13 | HENWOOD GERALDINE | CTO | Purchase | $11.69 | 2.50K | $29.23K | 2.50K |
| Feb 28, 13 | HENWOOD GERALDINE | CTO | Sale | $12.19 | 7.50K | $91.42K | -- |
| Feb 28, 13 | HENWOOD GERALDINE | CTO | Sale | $25.00 | 10.00K | $250.00K | -- |
| Feb 1, 13 | KELLERMAN DONALD J | Officer | Sale | $24.73 | 1.43K | $35.34K | 3.48K |
| Jan 25, 13 | KELLERMAN DONALD J | Officer | Sale | -- | 2.75K | -- | 8.25K |
| Jan 26, 13 | KELLERMAN DONALD J | Officer | Purchase | -- | 2.25K | -- | 5.78K |
| Jan 26, 13 | KELLERMAN DONALD J | Officer | Sale | $24.75 | 871 | $21.56K | 4.91K |
| Jan 25, 13 | KELLERMAN DONALD J | Officer | Purchase | -- | 2.75K | -- | 4.74K |
| Jan 26, 13 | KELLERMAN DONALD J | Officer | Sale | -- | 2.25K | -- | 4.50K |
| Jan 25, 13 | KELLERMAN DONALD J | Officer | Sale | $24.75 | 1.21K | $29.87K | 3.53K |
| Nov 20, 12 | KELLERMAN DONALD J | Officer | Purchase | $9.89 | 557 | $5.51K | 1.99K |
| Dec 31, 12 | KELLERMAN DONALD J | Officer | Sale | -- | -- | -- | -- |
| Nov 23, 12 | HENWOOD GERALDINE | CTO | Purchase | $3.18 | 3.75K | $11.93K | 3.75K |
| Nov 23, 12 | HENWOOD GERALDINE | CTO | Purchase | $0.74 | 1.49K | $1.10K | 1.49K |
| Nov 23, 12 | HENWOOD GERALDINE | CTO | Sale | $15.00 | 3.75K | $56.25K | -- |
| Nov 23, 12 | HENWOOD GERALDINE | CTO | Sale | $0.74 | 1.49K | $1.10K | -- |
| Nov 23, 12 | HENWOOD GERALDINE | CTO | Sale | $3.18 | 3.75K | $11.93K | -- |
| May 17, 12 | WARD SCOTT R | CTO | Purchase | $11.69 | 10.00K | $116.90K | 10.00K |
| May 17, 12 | HENWOOD GERALDINE | CTO | Purchase | $11.69 | 10.00K | $116.90K | 10.00K |
| Jan 25, 12 | KELLERMAN DONALD J | Officer | Purchase | $14.09 | 32.50K | $457.93K | 32.50K |
| Jan 25, 12 | KELLERMAN DONALD J | Officer | Purchase | -- | 11.00K | -- | 11.00K |
| Jan 26, 12 | KELLERMAN DONALD J | Officer | Sale | -- | 2.25K | -- | 6.75K |
| Jan 26, 12 | KELLERMAN DONALD J | Officer | Purchase | -- | 2.25K | -- | 2.37K |
| Jan 26, 12 | KELLERMAN DONALD J | Officer | Sale | $13.84 | 943 | $13.05K | 1.43K |
| Dec 2, 11 | KELLERMAN DONALD J | Officer | Sale | $13.62 | 3.00K | $40.86K | 122 |
| Aug 24, 11 | KELLERMAN DONALD J | Officer | Sale | $12.34 | 4.00K | $49.37K | 3.12K |
| Aug 4, 11 | KELLERMAN DONALD J | Officer | Purchase | -- | 11.25K | -- | 11.25K |
| Aug 4, 11 | KELLERMAN DONALD J | Officer | Sale | $13.43 | 4.13K | $55.44K | 7.12K |
| Aug 4, 11 | KELLERMAN DONALD J | Officer | Sale | -- | 11.25K | -- | 7.12K |
| May 19, 11 | HENWOOD GERALDINE | CTO | Purchase | $16.47 | 7.50K | $123.52K | 7.50K |
| May 19, 11 | WARD SCOTT R | CTO | Purchase | $16.47 | 7.50K | $123.52K | 7.50K |
| Mar 11, 11 | WARD SCOTT R | CTO | Purchase | $15.69 | 2.00K | $31.38K | 2.00K |
| Jan 26, 11 | KELLERMAN DONALD J | Officer | Purchase | $16.15 | 27.50K | $444.12K | 27.50K |
| Jan 26, 11 | KELLERMAN DONALD J | Officer | Purchase | -- | 9.00K | -- | 9.00K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Purchase | $0.74 | 4.39K | $3.26K | 4.39K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $3.18 | 3.75K | $11.93K | 3.75K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Purchase | $3.18 | 3.75K | $11.93K | 3.75K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Purchase | $0.64 | 1.63K | $1.04K | 1.63K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $0.74 | 4.39K | $3.26K | 1.49K |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $15.66 | 4.39K | $68.71K | -- |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $15.66 | 3.75K | $58.71K | -- |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $0.64 | 1.63K | $1.04K | -- |
| Oct 27, 10 | HENWOOD GERALDINE | CTO | Sale | $15.65 | 1.63K | $25.47K | -- |
| Aug 5, 10 | HENWOOD GERALDINE | CTO | Purchase | $0.74 | 12.00K | $8.92K | 12.00K |
| Aug 5, 10 | HENWOOD GERALDINE | CTO | Sale | $0.74 | 12.00K | $8.92K | 5.88K |
| Aug 5, 10 | HENWOOD GERALDINE | CTO | Sale | $12.78 | 12.00K | $153.41K | -- |
| May 20, 10 | ELMS STEVE | CTO | Purchase | $14.77 | 7.50K | $110.78K | 7.50K |
| May 20, 10 | WARD SCOTT R | CTO | Purchase | $14.77 | 7.50K | $110.78K | 7.50K |
| May 20, 10 | HENWOOD GERALDINE | CTO | Purchase | $14.77 | 7.50K | $110.78K | 7.50K |
| May 20, 10 | GOLDFISCHER CARL | CTO | Purchase | $14.77 | 7.50K | $110.78K | 7.50K |
| May 11, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | -- | 777.12K | -- | 2.05M |
| Mar 12, 10 | GOLDFISCHER CARL | CTO | Sale | $16.30 | 105.00K | $1.71M | 1.90M |
| Mar 15, 10 | GOLDFISCHER CARL | CTO | Sale | $16.01 | 42.18K | $675.24K | 1.86M |
| Mar 16, 10 | GOLDFISCHER CARL | CTO | Sale | $16.20 | 115.61K | $1.87M | 1.74M |
| Mar 12, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $16.11 | 706 | $11.37K | 2.83M |
| Mar 10, 10 | ELMS STEVE | CTO | Sale | $16.15 | 2.09K | $33.75K | -- |
| Mar 9, 10 | GOLDFISCHER CARL | CTO | Sale | $15.50 | 151.42K | $2.35M | 2.20M |
| Mar 10, 10 | GOLDFISCHER CARL | CTO | Sale | $16.03 | 134.19K | $2.15M | 2.06M |
| Mar 11, 10 | GOLDFISCHER CARL | CTO | Sale | $16.06 | 54.30K | $872.06K | 2.01M |
| Mar 8, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $14.61 | 81.42K | $1.19M | 2.84M |
| Mar 9, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $15.40 | 16.37K | $252.04K | 2.83M |
| Mar 4, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $14.09 | 2.50K | $35.27K | 3.13M |
| Mar 4, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $14.15 | 3.06K | $43.31K | 3.13M |
| Mar 5, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | $13.95 | 168.38K | $2.35M | 2.93M |
| Feb 22, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Purchase | -- | 706 | -- | 3.14M |
| Feb 22, 10 | ELMS STEVE | CTO | Purchase | -- | 2 | -- | 2.03K |
| Feb 11, 10 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Sale | -- | 941.70K | -- | 3.13M |
| Feb 11, 10 | ELMS STEVE | CTO | Sale | -- | 2.09K | -- | 2.09K |
| May 21, 09 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Purchase | $3.18 | 7.50K | $23.85K | 7.50K |
| Feb 2, 10 | KELLERMAN DONALD J | Officer | Purchase | $16.19 | 55.00K | $890.45K | 55.00K |
| Feb 2, 10 | KELLERMAN DONALD J | Officer | Purchase | -- | 22.50K | -- | 22.50K |
| Nov 18, 09 | HENWOOD GERALDINE | CTO | Purchase | $0.64 | 16.25K | $10.42K | 16.25K |
| Nov 18, 09 | HENWOOD GERALDINE | CTO | Sale | $0.64 | 16.25K | $10.42K | 1.63K |
| Nov 18, 09 | HENWOOD GERALDINE | CTO | Sale | $8.77 | 16.25K | $142.44K | -- |
| May 21, 09 | GOLDFISCHER CARL | CTO | Sale | $3.18 | 7.50K | $23.85K | 7.50K |
| May 21, 09 | HENWOOD GERALDINE | CTO | Sale | $3.18 | 7.50K | $23.85K | 7.50K |
| May 21, 09 | WARD SCOTT R | CTO | Sale | $3.18 | 7.50K | $23.85K | 7.50K |
| Feb 11, 09 | KELLERMAN DONALD J | Officer | Purchase | $10.37 | 35.00K | $362.95K | 35.00K |
| Sep 24, 08 | WARD SCOTT R | CTO | Purchase | $8.98 | 30.00K | $269.40K | 30.00K |
| Sep 24, 08 | WARD SCOTT R | CTO | Sale | -- | -- | -- | -- |
| Jul 23, 08 | KELLERMAN DONALD J | Officer | Purchase | $9.20 | 40.00K | $368.00K | -- |
| Jul 22, 08 | KELLERMAN DONALD J | Officer | Sale | -- | -- | -- | -- |
| May 22, 08 | SOROS FUND MANAGEMENT LLC | 10 percent owner | Purchase | $12.19 | 7.50K | $91.42K | 7.50K |
| May 22, 08 | ELMS STEVE | CTO | Purchase | $12.19 | 7.50K | $91.42K | 7.50K |
| May 22, 08 | GOLDFISCHER CARL | CTO | Purchase | $12.19 | 7.50K | $91.42K | 7.50K |
| May 22, 08 | HENWOOD GERALDINE | CTO | Purchase | $12.19 | 7.50K | $91.42K | 7.50K |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Purchase | $12.00 | 175.00K | $2.10M | 4.08M |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Purchase | -- | 784.68K | -- | 3.90M |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Purchase | -- | 828.15K | -- | 3.12M |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Purchase | -- | 1.40M | -- | 2.29M |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Purchase | -- | 610.17K | -- | 884.57K |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 828.15K | -- | -- |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 784.68K | -- | -- |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 1.40M | -- | -- |
| Oct 11, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 610.17K | -- | -- |
| Oct 11, 07 | GOLDFISCHER CARL | CTO | Purchase | $14.50 | 2.17M | $31.48M | 2.35M |
| Oct 11, 07 | GOLDFISCHER CARL | CTO | Purchase | $14.50 | 176.47K | $2.56M | 176.47K |
| Oct 11, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 448.96K | -- | -- |
| Oct 11, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 629.83K | -- | -- |
| Oct 11, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 1.09M | -- | -- |
| Oct 10, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 629.83K | -- | -- |
| Oct 10, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 1.09M | -- | -- |
| Oct 10, 07 | GOLDFISCHER CARL | CTO | Sale | -- | 448.96K | -- | -- |
| Oct 4, 07 | ELMS STEVE | CTO | Sale | -- | -- | -- | -- |
| Oct 4, 07 | HENWOOD GERALDINE | CTO | Sale | $0.64 | 17.88K | $11.44K | -- |
| Oct 4, 07 | HENWOOD GERALDINE | CTO | Sale | $0.74 | 17.88K | $13.23K | -- |
| Oct 4, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 610.17K | -- | -- |
| Oct 4, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 1.40M | -- | -- |
| Oct 4, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 828.15K | -- | -- |
| Oct 4, 07 | PERSEUS SOROS BIOPHARMACEUTICAL FUND LP | 10 percent owner | Sale | -- | 784.68K | -- | -- |