MNPR
Earnings in 8 days · May 12, 2026 · Before open
Signal
Mixed11
Price
1
Move+1.74%Positive session
Volume
1
Volume0.1× avgLight volume
Technical
1
RSIRSI 41Momentum negative
PRICE
Prev Close
53.25
Open
53.67
Day Range53.26 – 54.40
53.26
54.40
52W Range28.40 – 105.00
28.40
105.00
34% of range
VOLUME & SIZE
Avg Volume
192.8K
FUNDAMENTALS
P/E Ratio
-29.3x
Not profitable
EPS (TTM)
Div Yield
No dividend
Quick Read
TrendInsufficient MA data
Momentum
BEARISH
thin 0% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 51.4 · FCF negative
Neutral
Key MetricsTTM
Market Cap$362.57M
Revenue TTM$0.00
Net Income TTM-$13.72M
Free Cash Flow-$12.20M
Gross Margin0.0%
Net Margin0.0%
Operating Margin0.0%
Return on Equity-0.0%
Return on Assets-0.0%
Debt / Equity0.00
Current Ratio51.35
EPS TTM$-2.05
Alpha SignalsFull Analysis →
What Moves This Stock

Clinical trial data readouts and interim analysis results for MNPR-101 and MNPR-202 programs

FDA regulatory decisions including IND approvals, Fast Track designations, and Breakthrough Therapy status

Partnership announcements or licensing deals with major pharmaceutical companies

Cash runway updates and financing activities (equity raises, debt facilities)

Macro Sensitivity
Economic Cycle

low - Pre-revenue biotechs are largely insulated from GDP fluctuations as they generate no sales tied to economic activity. However, capital markets access is cyclically sensitive: risk-on environments improve equity financing terms while recessions tighten venture capital and public market funding. Clinical trial costs remain fixed regardless of economic conditions, though patient recruitment can be marginally affected by healthcare utilization patterns.

Interest Rates

Rising interest rates negatively impact valuation through two mechanisms: (1) higher discount rates applied to distant future cash flows reduce NPV of pipeline assets, particularly severe for clinical-stage companies with 5-10 year commercialization timelines, and (2) rates affect relative attractiveness versus fixed income, causing capital rotation away from speculative growth assets. The company's zero debt means no direct financing cost impact, but equity financing becomes more expensive as investor required returns increase.

Key Risks

Binary clinical trial outcomes with high failure rates (historically ~90% of oncology drugs fail to reach approval), creating total loss potential

Regulatory pathway uncertainty as FDA requirements for accelerated approval and surrogate endpoints continue evolving, particularly for oncology indications

Patent cliff risk if clinical development timelines consume significant patent life before commercialization, reducing market exclusivity period

Investor Profile

growth - Attracts speculative growth investors and biotech specialists willing to accept binary risk/reward profiles in exchange for potential multi-bagger returns from successful drug approvals. High volatility (evidenced by -33.2% 3-month return despite +65.6% 6-month return) appeals to momentum traders around catalyst events. Not suitable for value or income investors given zero revenue, negative earnings, and no dividend. Institutional ownership likely concentrated among healthcare-focused hedge funds and venture capital rather than broad index funds.

Watch on Earnings
Clinical trial milestone announcements and data readout timing for MNPR-101 and MNPR-202Quarterly cash burn rate and projected months of runway to key inflection pointsFDA regulatory feedback and designation status (Fast Track, Breakthrough Therapy, Orphan Drug)Biotech IPO and M&A activity as proxy for sector risk appetite and exit valuations
Health Radar
3 strong3 concern
50/100
Liquidity
51.35Strong
Leverage
0.00Strong
Coverage
0.0xConcern
ROE
-0.0%Concern
ROIC
-0.0%Concern
Cash
$61.8BStrong
ANALYST COVERAGE13 analysts
BUY
+119.6%upside to target
L $115.00
Med $119.00consensus
H $123.00
Buy
1185%
Hold
215%
11 Buy (85%)2 Hold (15%)0 Sell (0%)
Full report →
Stock Health
Composite Score
2 of 5 signals bullish
3/10
Technicals
RSI RangeRSI 41 — Bearish momentum
Volume
Volume FlowLean Distribution — selling pressure
Fundamentals
Last EarningsMissed estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 51.35 — healthy liquidity
Upcoming Events
EEarnings Report · Before OpenMay 5, 2026
Tomorrow
DEx-Dividend DateAug 2, 2026
In 90 days
Technicals
Technical SetupBEARISH
Technicals →

Trend

DowntrendDeath Cross · 50D trails 200D by 9.9%

-3.5% vs SMA 50 · -13.1% vs SMA 200

Momentum

RSI41.2
Momentum fading
MACD-0.76
Below zero — bearish pulse · compressing
Market Position
Price Levels
52W High
$105.0+93.8%
EMA 50
$57.53+6.2%
EMA 200
$56.90+5.0%
Current
$54.18
52W Low
$28.40-47.6%
52-Week RangeMid-range
$28.4034th %ile$105.0
Squeeze SetupVolume-based
No Clear Setup

Volume distribution is neutral or leaning toward distribution. No compelling squeeze setup based on current money flow data.

20-Day Money Flow
Acc days:7
Dist days:2
Edge:+5 acc
Volume Context
Avg Vol (50D)42K
Recent Vol (5D)
30K-29%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 10 analysts
Analyst revisions:EPS↑ Revised Up

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$0-$1.68
±20%
High9
FY2026(current)
$400000
$122547$541686
-$3.69
±50%
High10
FY2027
$17.3M
$3.2M$24.5M
+4227.2%-$3.58
±50%
High9
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryMNPR
Last 8Q
-53.3%avg beat
Beat 4 of 8 quartersMissed 4
+41%
Q2'24
-11%
Q3'24
+20%
Q4'24
-519%
Q1'25
+42%
Q2'25
+26%
Q3'25
-4%
Q4'25
-19%
Q1'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
Raymond JamesStrong Buy → Outperform
Nov 14
DOWNGRADE
Insider Activity
SEC Filings →
1 Buy/5 SellsNet Selling
Vu Quan AnhCFO
$105K
Dec 26
BUY
Klausner Arthur JDir
$312K
Dec 18
SELL
Klausner Arthur JDir
$31K
Dec 18
SELL
Tactic Pharma Llc10 Percent Own…
$35.0M
Sep 24
SELL
Tsuchimoto Kim RDir
$356K
Jul 14
SELL
Starr Christopher MDir
$672K
Jul 14
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
GERBER, LLC
6K
2
Nuveen, LLC
6K
3
Your Advocates Ltd., LLP
3K
4
Police & Firemen's Retirement System of New Jersey
964
5
GAMMA Investing LLC
29
6
Sterling Capital Management LLC
29
7
MOUNTAIN PACIFIC INVESTMENT ADVISERS INC/ID
0
8
JANUS HENDERSON GROUP PLC
1.3M
News & Activity

MNPR News

20 articles · 4h ago

About

monopar therapeutics inc., a biopharmaceutical company, engages in developing proprietary therapeutics to enhance clinical outcomes for cancer patients in the united states. it is involved in developing validive, a clonidine mucobuccal tablet that is in phase iii for the treatment of radiation induced severe oral mucositis in oropharyngeal cancer patients; camsirubicin, a topoisomerase ii-alpha targeted analog of doxorubicin engineered to retain anticancer activity and for minimizing toxic effects on the heart; and mnpr-101, a humanized monoclonal antibody for treating advanced solid cancers. the company has a collaboration grupo espaã±ol de investigaciã³n en sarcomas for the development of camsirubicin in patients with advanced soft tissue sarcoma; and northstar medical radioisotopes, llc to develop radio-immuno-therapeutics targeting severe covid-19. monopar therapeutics inc. was founded in 2014 and is headquartered in wilmette, illinois.

Industry
Research and Development in Biotechnology (except Nanobiotechnology)
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
MNPR
$54.18+0.00%$356M1500
$68.94-3.59%$13.3B+12626.1%-14525.8%1500
$518.96-0.71%$11.8B+43205.3%-3008.0%1500
$87.97+0.60%$11.5B+3288.2%-4239.0%1500
$182.26-1.59%$10.7B29.2+1871.5%680.1%1500
$228.48-0.59%$10.6B+6554.5%-2868.8%1500
$74.93+1.81%$10.5B51.8+2325815.3%-19.7%1500
Sector avg-0.58%40.5+398893.5%-3996.9%1500