NRIX
Next earnings: Jul 9, 2026 · Before open
Signal
Leaning Bullish1
Price
1
Move+0.71%Quiet session
Volume
1
Volume0.5× avgNormal activity
Technical
1
RSIRSI 55Momentum positive
PRICE
Prev Close
16.81
Open
16.66
Day Range16.50 – 17.27
16.50
17.27
52W Range8.20 – 22.50
8.20
22.50
61% of range
VOLUME & SIZE
Avg Volume
1.1M
FUNDAMENTALS
P/E Ratio
-5.3x
Not profitable
EPS (TTM)
Div Yield
No dividend
Beta
1.53
High vol
Performance
1D
+0.66%
5D
-0.18%
1M
+6.46%
3M
+1.57%
6M
+37.11%
YTD
-11.39%
1Y
+53.66%
Best: 1Y (+53.66%)Worst: YTD (-11.39%)
Quick Read
TrendInsufficient MA data
Momentum
NEUTRAL
rev +27% · -139% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 6.0 · FCF negative
Lean Bullish
Key MetricsTTM
Market Cap$1.47B
Revenue TTM$71.78M
Net Income TTM-$295.28M
Free Cash Flow-$271.85M
Gross Margin-139.4%
Net Margin-411.4%
Operating Margin-439.3%
Return on Equity-64.2%
Return on Assets-46.4%
Debt / Equity0.12
Current Ratio6.01
EPS TTM$-2.68
Alpha SignalsFull Analysis →
What Moves This Stock

Clinical trial data readouts for NX-2127 (BTK degrader) and NX-5948 - efficacy, safety, and differentiation versus existing BTK inhibitors like Imbruvica and Calquence

New partnership announcements or expansion of existing Sanofi/Gilead collaborations - upfront payments, milestone structures, and validation of DELigase platform

Regulatory milestones including IND filings for new programs and Phase 2 trial initiations for lead assets

Cash runway updates and financing activities - equity raises, debt facilities, or non-dilutive funding that extend operational runway beyond current 18-24 month estimates

Macro Sensitivity
Economic Cycle

low - Clinical-stage biotech with no product revenue, insulated from consumer spending or GDP fluctuations. Development timelines driven by scientific milestones rather than economic conditions. However, partnership activity and M&A valuations can be affected during severe recessions when pharma companies reduce external investment. Collaboration revenue (~$100M TTM) provides modest stability but represents research funding rather than economically-sensitive product sales.

Interest Rates

Rising interest rates create moderate headwinds through two channels: (1) higher discount rates compress NPV of distant cash flows from pipeline assets (2028+ commercialization), disproportionately impacting pre-revenue biotech valuations and contributing to sector multiple compression, and (2) increased opportunity cost makes cash-burning growth stocks less attractive versus risk-free alternatives, reducing investor appetite for speculative biotech. However, $350-400M cash position (estimated) generates modest interest income benefit. Rate sensitivity primarily manifests through valuation multiples rather than operational impact.

Key Risks

Clinical trial failure risk - NX-2127 or NX-5948 could fail to demonstrate sufficient efficacy or acceptable safety versus existing BTK inhibitors, potentially eliminating 60-70% of current pipeline value and triggering significant stock decline

Protein degradation platform validation risk - technology remains relatively novel with limited approved precedents (only Imbruvica/Calquence as BTK inhibitors, no approved degraders), creating uncertainty around commercial viability and competitive differentiation

Regulatory pathway uncertainty for novel degrader mechanisms - FDA may require additional safety studies or longer development timelines given limited precedent, extending time-to-market and capital requirements

Investor Profile

growth - Attracts speculative biotech investors focused on clinical-stage pipeline optionality and platform technology upside. The 47.8% six-month return reflects momentum from positive clinical updates or partnership news, while -6.5% one-year return shows volatility typical of binary event-driven biotech. Not suitable for value or income investors given negative profitability, no dividends, and high cash burn. Investor base consists primarily of biotech-specialized funds, crossover healthcare investors, and retail traders seeking high-risk/high-reward clinical catalyst plays.

Watch on Earnings
NX-2127 Phase 1b/2 clinical data releases - objective response rates, duration of response, and safety profile in relapsed/refractory B-cell malignanciesNX-5948 Phase 1 dose escalation progress and recommended Phase 2 dose determination for autoimmune indicationsQuarterly cash burn rate and ending cash balance - tracking runway and financing needsNew IND filings and pipeline expansion from DELigase platform - productivity metric for discovery engine
Health Radar
3 strong3 concern
49/100
Liquidity
6.01Strong
Leverage
0.12Strong
Coverage
0.0xConcern
ROE
-64.2%Concern
ROIC
-57.6%Concern
Cash
$247MStrong
ANALYST COVERAGE17 analysts
BUY
+83.1%upside to target
L $28.00
Med $31.00consensus
H $36.00
Buy
17100%
17 Buy (100%)0 Hold (0%)0 Sell (0%)
Full report →
Stock Health
Composite Score
3 of 5 signals bullish
5/10
Technicals
RSI RangeRSI 55 — Bullish momentum
Volume
Volume FlowDistribution — institutional selling
Fundamentals
Last EarningsMissed estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 6.01 — healthy liquidity
Upcoming Events
EEarnings Report · After CloseMay 5, 2026
Tomorrow
DEx-Dividend DateAug 2, 2026
In 90 days
Technicals
Technical SetupBEARISH
Technicals →

Trend

PullbackGolden Cross · 50D leads 200D by 31.2%

-2.5% vs SMA 50 · +27.8% vs SMA 200

Momentum

RSI54.8
Neutral territory
MACD-0.47
Below zero — bearish pulse · expanding
Market Position
Price Levels
52W High
$22.50+32.9%
Current
$16.93
EMA 50
$16.47-2.7%
EMA 200
$13.40-20.8%
52W Low
$8.20-51.6%
52-Week RangeMid-range
$8.2061th %ile$22.50
Squeeze SetupVolume-based
Distribution Pressure

Distribution pattern detected. More selling days than accumulation over the past 20 sessions. Not a conducive environment for a squeeze.

20-Day Money Flow
Acc days:2
Dist days:4
Edge:+2 dist
Volume Context
Avg Vol (50D)875K
Recent Vol (5D)
678K-23%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 13 analysts
Analyst revisions:EPS↓ Revised DownRevenue↑ Revised Up

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$85.2M
$74.3M$105.1M
-$3.04
±12%
High12
FY2026(current)
$56.4M
$49.7M$70.1M
-33.8%-$2.95
±11%
High13
FY2027
$75.1M
$36.8M$156.0M
+33.1%-$2.83
±28%
High12
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryNRIX
Last 8Q
-1.2%avg beat
Beat 3 of 8 quartersMissed 4 Estimates falling
-8%
Q3'24
Q4'24
-12%
Q1'25
+7%
Q2'25
+27%
Q3'25
-23%
Q4'25
+2%
Q1'26
-4%
Q2'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
Morgan StanleyEqual-Weight → Overweight
Jan 8
UPGRADE
Wells FargoOverweight
May 31
UPGRADE
Insider Activity
SEC Filings →
0 Buys/6 SellsNet Selling
NET SELLERS$0 bought · $375K sold · 30d window
Ring ChristineChief Legal Of…
$138K
May 4
SELL
Ring ChristineChief Legal Of…
$90K
May 1
SELL
Van Houte HansCFO
$40K
Apr 30
SELL
Ring ChristineChief Legal Of…
$53K
Apr 30
SELL
Hansen GwennChief Scientif…
$53K
Apr 30
SELL
Ring ChristineChief Legal Of…
$124K
Apr 2
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
Pictet Asset Management Holding SA
2.7M
2
Sumitomo Mitsui Trust Holdings, Inc.
1.2M
3
Nuveen, LLC
813K
4
Handelsbanken Fonder AB
547K
5
Candriam S.C.A.
534K
6
WestHill Financial Advisors, Inc.
228K
7
PROFUND ADVISORS LLC
67K
8
Y-Intercept (Hong Kong) Ltd
55K
News & Activity

NRIX News

20 articles · 4h ago

About

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development, and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and other challenging diseases. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix’s wholly owned pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Industry
Pharmaceutical Preparation Manufacturing
Arthur T. SandsChief Executive Officer, President & Director
Christopher PhelpsSenior Vice President & Head of Early Drug Discovery
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
NRIX
$16.93+0.66%$1.5B+5395.3%-31490.5%1500
$68.99-3.59%$13.3B+12626.1%-14525.8%1500
$518.66-0.71%$11.8B+43205.3%-3008.0%1500
$91.17+0.60%$11.5B+3288.2%-4239.0%1500
$182.03-1.59%$10.7B29.2+1871.5%680.1%1500
$223.70-0.59%$10.6B+6554.5%-2868.8%1500
$76.39+1.81%$10.5B51.8+2325815.3%-19.7%1500
Sector avg-0.49%40.5+342679.5%-7924.5%1500