NUVL
Earnings in 2 days · May 7, 2026 · Before open
Signal
Bullish Setup2
Price
1
Move+3.61%Strong session
Volume
1
Volume1.0× avgNormal activity
Technical
1
RSIRSI 63Momentum positive
PRICE
Prev Close
99.04
Open
98.28
Day Range98.28 – 103.07
98.28
103.07
52W Range63.56 – 113.02
63.56
113.02
79% of range
VOLUME & SIZE
Avg Volume
560.0K
FUNDAMENTALS
P/E Ratio
-17.5x
Not profitable
EPS (TTM)
Div Yield
No dividend
Beta
2.00
High vol
Performance
1D
+3.61%
5D
+1.76%
1M
-1.05%
3M
-2.26%
6M
+12.74%
YTD
+2.02%
1Y
+36.05%
Best: 1Y (+36.05%)Worst: 3M (-2.26%)
Quick Read
TrendInsufficient MA data
Momentum
BEARISH
thin 0% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 15.3 · FCF negative
Neutral
Key MetricsTTM
Market Cap$7.55B
Revenue TTM$0.00
Net Income TTM-$425.38M
Free Cash Flow-$275.21M
Gross Margin0.0%
Net Margin0.0%
Operating Margin0.0%
Return on Equity-42.1%
Return on Assets-30.1%
Debt / Equity0.00
Current Ratio15.27
EPS TTM$-5.66
Alpha SignalsFull Analysis →
What Moves This Stock

Clinical trial data readouts for zidesamtinib (NVL-520) in ROS1+ NSCLC - objective response rates (ORR), duration of response (DOR), and intracranial activity

NVL-655 Phase 1/2 data in ALK+ NSCLC, particularly activity against lorlatinib-resistant mutations and CNS metastases

FDA regulatory interactions - IND clearances for new programs, breakthrough therapy designations, or accelerated approval pathways

Strategic partnerships or licensing deals with large pharma for ex-US rights or combination therapy development

Macro Sensitivity
Economic Cycle

low - Clinical trial timelines and regulatory processes are largely insulated from GDP fluctuations. However, severe recessions can impact: (1) capital markets access for future financing rounds, (2) pharma M&A appetite and partnership valuations, and (3) healthcare system capacity for trial site operations. Oncology drug demand is non-discretionary and recession-resistant post-approval.

Interest Rates

Rising rates negatively impact valuation through higher discount rates applied to distant cash flows (first revenues likely 2028+). Clinical-stage biotech with 5-7 year commercialization timelines are particularly sensitive to the risk-free rate used in DCF models. Higher rates also increase opportunity cost versus bonds for growth investors and can compress biotech sector multiples. Minimal direct business impact as the company carries no debt (0.00 D/E ratio), but future financing costs and dilution risk increase if equity markets weaken.

Key Risks

Binary clinical trial risk - Phase 2/3 failures would eliminate near-term value as ROS1+ NSCLC affects only ~2,000-3,000 US patients annually (1-2% of NSCLC), requiring high efficacy for commercial viability

Regulatory pathway uncertainty for accelerated approval in rare oncology indications with evolving FDA standards for single-arm trials and surrogate endpoints

Reimbursement pressure as payers scrutinize oncology drug pricing, particularly for incremental improvements over existing TKIs like crizotinib or entrectinib

Investor Profile

growth - Attracts specialized biotech investors, healthcare-focused hedge funds, and venture capital crossover funds seeking high-risk, high-reward clinical-stage opportunities. The 29.1% one-year return and 36.3% six-month return reflect momentum from positive clinical updates. Institutional ownership likely concentrated among funds with oncology expertise (Fidelity, T. Rowe Price biotech teams). Not suitable for value or income investors given zero revenue, negative margins, and no dividend. Requires tolerance for binary event risk and 3-5 year investment horizons.

Watch on Earnings
Zidesamtinib (NVL-520) Phase 2 objective response rate (ORR) and intracranial response rate versus 70%+ targetNVL-655 activity against ALK G1202R and compound mutations resistant to lorlatinibQuarterly cash burn rate and remaining runway to key data readoutsBiotech IPO and follow-on offering market conditions (XBI index performance)
Health Radar
3 strong3 concern
44/100
Liquidity
15.27Strong
Leverage
0.00Strong
Coverage
0.0xConcern
ROE
-42.1%Concern
ROIC
-31.4%Concern
Cash
$262MStrong
ANALYST COVERAGE14 analysts
BUY
+45.2%upside to target
L $126.00
Med $149.00consensus
H $155.00
Buy
14100%
14 Buy (100%)0 Hold (0%)0 Sell (0%)
Full report →
Stock Health
Composite Score
4 of 5 signals bullish
7/10
Technicals
RSI RangeRSI 63 — Bullish momentum
Volume
Volume FlowDistribution — institutional selling
Fundamentals
Last EarningsBeat estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 15.27 — healthy liquidity
Upcoming Events
EEarnings ReportMay 6, 2026
Tomorrow
DEx-Dividend DateAug 3, 2026
In 90 days
PDividend PaymentAug 20, 2026
In 107 days
Technicals
Technical SetupBULLISH
Technicals →

Trend

UptrendGolden Cross · 50D leads 200D by 30.3%

+1.5% vs SMA 50 · +32.2% vs SMA 200

Momentum

RSI63.4
Positive momentum, not extended
MACD+0.18
Above zero — bullish momentum · compressing
Market Position
Price Levels
52W High
$113.0+10.1%
Current
$102.6
EMA 50
$100.1-2.5%
EMA 200
$77.64-24.3%
52W Low
$63.55-38.1%
52-Week RangeNear 52-week high
$63.5579th %ile$113.0
Squeeze SetupVolume-based
Distribution Pressure

Distribution pattern detected. More selling days than accumulation over the past 20 sessions. Not a conducive environment for a squeeze.

20-Day Money Flow
Acc days:4
Dist days:3
Edge:+1 acc
Volume Context
Avg Vol (50D)494K
Recent Vol (5D)
371K-25%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 14 analysts
Analyst revisions:EPS↓ Revised DownRevenue↓ Revised Down

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$6.3M
$2.5M$11.1M
-$5.72
±1%
High12
FY2026(current)
$13.8M
$538551$32.2M
+121.0%-$5.56
±26%
High14
FY2027
$187.2M
$105.6M$259.4M
+1255.1%-$4.21
±50%
High13
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryNUVL
Last 8Q
-9.1%avg beat
Beat 1 of 8 quartersMissed 7 Estimates falling
-3%
Q2'24
-16%
Q3'24
-37%
Q4'24
-1%
Q1'25
-4%
Q2'25
-3%
Q3'25
-22%
Q4'25
+13%
Q1'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
Leerink PartnersOutperform
Apr 1
UPGRADE
Insider Activity
SEC Filings →
0 Buys/6 SellsNet Selling
NET SELLERS$0 bought · $4.5M sold · 30d window
Miller Deborah AnnChief Legal Of…
$438K
Apr 30
SELL
Miller Deborah AnnChief Legal Of…
$108K
Apr 30
SELL
Noci DarleneChief Developm…
$447K
Apr 29
SELL
Noci DarleneChief Developm…
$70K
Apr 29
SELL
Noci DarleneChief Developm…
$30K
Apr 29
SELL
Pelish Henry E.Chief Scientif…
$229K
Apr 9
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
Pictet Asset Management Holding SA
410K
2
Candriam S.C.A.
391K
3
abrdn plc
124K
4
Nuveen, LLC
110K
5
TEMA ETFS LLC
53K
6
FIFTH THIRD BANCORP
24K
7
PROFUND ADVISORS LLC
21K
8
SG Americas Securities, LLC
17K
News & Activity

NUVL News

20 articles · 4h ago

About

nuvalent is improving human health by developing breakthrough small molecule therapeutics that engage biological targets in new ways using cutting-edge chemical insights. by expanding the universe of targets that interact with small molecules, we are generating therapeutics with activities not previously possible, including modulation of ‘undruggable’ targets. our unique approach is leading to first-in-class and best-in-class small molecule therapeutics that will significantly impact patient’s lives.

Industry
Research and Development in Biotechnology (except Nanobiotechnology)
Matthew MetivierSenior Vice President of Human Resources
James R. PorterChief Executive Officer, President & Director
John SogliaSenior Vice President of Translational Development
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
NUVL
$102.62+3.61%$7.5B1500
$68.99+0.00%$13.4B1500
$91.17+0.00%$12.0B-4239.0%1500
$518.66+0.96%$11.9B-3008.0%1500
$223.70+8.31%$11.4B+6554.5%-2868.8%1500
$76.39+0.00%$10.7B52.9+2325815.3%-19.7%1500
$182.03+0.00%$10.6B1500
Sector avg+1.84%52.9+1166184.9%-2533.9%1500