PVLA
Earnings in 2 days · May 7, 2026 · Before open
Signal
Bullish Setup2
Price
1
Move+1.04%Positive session
Volume
1
Volume0.4× avgLight volume
Technical
1
TrendFull UptrendAbove 50D & 200D
PRICE
Prev Close
127.61
Open
128.97
Day Range124.24 – 129.76
124.24
129.76
52W Range20.20 – 151.18
20.20
151.18
83% of range
VOLUME & SIZE
Avg Volume
304.5K
Float
11.8M
FUNDAMENTALS
P/E Ratio
-34.9x
Not profitable
EPS (TTM)
$-3.70
Div Yield
No dividend
Performance
1D
+0.61%
5D
+2.59%
1M
+6.47%
3M
+55.60%
6M
+70.01%
YTD
+21.92%
1Y
+434.83%
Best: 1Y (+434.83%)
Quick Read
Earnings in 2d · May 7
Trend
UPTREND
Price above SMA50 & SMA200
Momentum
NEUTRAL
0% gross margin
Valuation
FAIR
P/E not available
Health
MODERATE
CR 5.2 · FCF negative
Bullish
Key MetricsTTM
Market Cap$1.52B
Revenue TTM$0.00
Net Income TTM-$41.72M
Free Cash Flow-$25.01M
Gross Margin0.0%
Net Margin0.0%
Operating Margin0.0%
Return on Equity-98.1%
Return on Assets-70.0%
Debt / Equity0.02
Current Ratio5.20
EPS TTM$-3.71
Alpha SignalsFull Analysis →
What Moves This Stock

Phase 3 SELVA trial topline data readout for microcystic LM (primary endpoint: investigator-assessed response rate)

FDA regulatory milestone achievements including NDA submission timing and approval decisions for orphan drug designation

Clinical data updates from Phase 2 PROS trial showing efficacy in PIK3CA-mutation patients

Cash runway extensions through equity financings or strategic partnerships impacting dilution risk

Macro Sensitivity
Economic Cycle

low - Pre-revenue biotech with value driven entirely by binary clinical and regulatory outcomes rather than economic conditions. R&D spending is committed regardless of GDP growth. Post-approval, orphan drug demand is highly inelastic as treatments address life-altering rare diseases with limited alternatives, insulating revenue from consumer spending cycles.

Interest Rates

Rising interest rates create moderate headwinds through two mechanisms: (1) Higher discount rates compress NPV of future cash flows in DCF models, disproportionately impacting pre-revenue biotechs with distant monetization timelines. (2) Increased financing costs for future capital raises, though current 6.49x current ratio provides near-term buffer. However, clinical catalysts typically override rate-driven valuation pressure for binary event stocks.

Key Risks

Binary regulatory risk: FDA approval failure for QTORIN rapamycin would eliminate primary value driver, with microcystic LM representing narrow indication with limited pivot options

Orphan drug market size constraints: Total addressable market of 4,000-6,000 US microcystic LM patients limits peak revenue potential to $400-600M annually even at high penetration rates

Reimbursement uncertainty: Payer willingness to cover ultra-rare topical therapies at premium pricing remains unproven, particularly for conditions without established treatment paradigms

Investor Profile

growth - Attracts speculative biotech investors seeking asymmetric risk/reward from binary clinical catalysts. The 281.6% one-year return and 69.3% six-month return reflect momentum-driven trading around clinical milestones. High volatility profile appeals to event-driven hedge funds and retail biotech traders rather than value or income investors. Institutional ownership likely concentrated among specialized healthcare funds with expertise evaluating clinical trial probability of success.

Watch on Earnings
Phase 3 SELVA trial enrollment completion and topline data announcement timingFDA orphan drug designation confirmations and breakthrough therapy designation applicationsCash and equivalents balance relative to projected quarterly burn rate through anticipated NDA approvalInvestigator-assessed response rates and safety profile data from ongoing clinical trials
Health Radar
3 strong3 concern
50/100
Liquidity
5.20Strong
Leverage
0.02Strong
Coverage
-6.6xConcern
ROE
-98.1%Concern
ROIC
-79.7%Concern
Cash
$58MStrong
ANALYST COVERAGE10 analysts
BUY
+58.6%upside to target
L $143.00
Med $204.50consensus
H $255.00
Strong Buy
110%
Buy
990%
10 Buy (100%)0 Hold (0%)0 Sell (0%)
Full report →
Stock Health
Composite Score
6 of 7 signals bullish
9/10
Trend
Trend StateUptrend (price above both MAs)
Above SMA 50$125.59 (+2.7%)
Above SMA 200$86.34 (+49.3%)
Technicals
MA AlignmentGolden Cross (50D vs 200D +45.5%)
Fundamentals
Last EarningsMissed estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 5.20 — healthy liquidity
Upcoming Events
EEarnings ReportMay 6, 2026
Tomorrow
DEx-Dividend DateAug 3, 2026
In 90 days
PDividend PaymentAug 20, 2026
In 107 days
Technicals
Market Position
Price Levels
52W High
$151.2+17.3%
Current
$128.9
SMA 50
$125.6-2.6%
SMA 200
$86.34-33.0%
52W Low
$20.20-84.3%
52-Week RangeNear 52-week high
$20.2083th %ile$151.2
Earnings & Analysts

ANALYST ESTIMATES

Consensus of 12 analysts
Analyst revisions:EPS↑ Revised Up

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$0-$3.52
±12%
High12
FY2026(current)
$26667
$11781$57326
-$5.16
±32%
High12
FY2027
$31.9M
$16.4M$66.4M
+119350.8%-$6.04
±48%
High11
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryPVLA
Last 8Q
+111.9%avg beat
Beat 3 of 8 quartersMissed 5 Estimates rising
+58%
Q2'24
-15%
Q3'24
-302%
Q4'24
+1126%
Q1'25
+78%
Q2'25
-10%
Q3'25
-21%
Q4'25
-19%
Q1'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Insider Activity
SEC Filings →
1 Buy/5 SellsNet Selling
NET SELLERS$0 bought · $547K sold · 30d window
Goin KathleenCOO
$189K
Apr 15
SELL
Goin KathleenCOO
$191K
Apr 15
SELL
Goin KathleenCOO
$72K
Apr 15
SELL
Goin KathleenCOO
$83K
Apr 15
SELL
Goin KathleenCOO
$13K
Apr 15
SELL
Jenkins George MDir
$50K
Mar 30
BUY
Financials

INSTITUTIONAL OWNERSHIP

1
EMERALD ADVISERS, LLC
162K
2
EMERALD MUTUAL FUND ADVISERS TRUST
106K
3
Clio Asset Management LLC
91K
4
abrdn plc
81K
5
Nuveen, LLC
21K
6
FIFTH THIRD BANCORP
20K
7
Calamos Advisors LLC
10K
8
PROFUND ADVISORS LLC
6K
News & Activity

PVLA News

20 articles · 4h ago

About

No company information available

PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
PVLA
+0.61%
$68.37+0.00%$13.4B1500
$89.49+0.00%$12.0B-4239.0%1500
$507.78+0.96%$11.9B-3008.0%1500
$224.43+8.31%$11.4B+6554.5%-2868.8%1500
$74.39+0.00%$10.7B52.9+2325815.3%-19.7%1500
$176.84+0.00%$10.6B1500
Sector avg+1.41%52.9+1166184.9%-2533.9%1500