| RA CAPITAL MANAGEMENT, L.P. | 9.91M | Jun 30, 26 | -- | 21.94% |
| TPG GP A, LLC | 6.49M | Jun 30, 26 | -- | 14.39% |
| VIKING GLOBAL INVESTORS LP | 3.20M | Jun 30, 26 | -- | 7.08% |
| Atlas Venture Life Science Advisors, LLC | 3.00M | Jun 30, 26 | -- | 6.63% |
| ORBIMED ADVISORS LLC | 2.56M | Jun 30, 26 | -974.83K | 5.66% |
| Enavate Sciences GP, LLC | 2.48M | Jun 30, 26 | -- | 5.49% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.60M | Jun 30, 26 | +1.45M | 3.54% |
| JPMORGAN CHASE & CO | 1.49M | Jun 30, 26 | +25.49K | 3.30% |
| BlackRock, Inc. | 1.47M | Jun 30, 26 | +178.90K | 3.27% |
| JENNISON ASSOCIATES LLC | 1.17M | Jun 30, 26 | -279.09K | 2.60% |
| CITADEL ADVISORS LLC | 1.15M | Jun 30, 26 | -19.30K | 2.54% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.13M | Jun 30, 26 | +102.50K | 2.51% |
| STATE STREET CORP | 1.02M | Jun 30, 26 | +265.31K | 2.26% |
| PERCEPTIVE ADVISORS LLC | 905.00K | Jun 30, 26 | +246.56K | 2.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 680.92K | Jun 30, 26 | -289.67K | 1.51% |
| Siren, L.L.C. | 610.51K | Jun 30, 26 | +310.51K | 1.35% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 478.02K | Jun 30, 26 | -278.36K | 1.06% |
| EVENTIDE ASSET MANAGEMENT, LLC | 474.98K | Jun 30, 26 | -170.55K | 1.05% |
| GEODE CAPITAL MANAGEMENT, LLC | 457.14K | Jun 30, 26 | +67.27K | 1.01% |
| Casdin Capital, LLC | 400.00K | Jun 30, 26 | +400.00K | 0.89% |
| BAKER BROS. ADVISORS LP | 400.00K | Jun 30, 26 | -- | 0.89% |
| GOLDMAN SACHS GROUP INC | 388.81K | Jun 30, 26 | +125.64K | 0.86% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 385.45K | Jun 30, 26 | +308.81K | 0.85% |
| FRANKLIN RESOURCES INC | 290.11K | Jun 30, 26 | +114.63K | 0.64% |
| abrdn plc | 284.14K | Jun 30, 26 | -280.04K | 0.63% |
| FMR LLC | 278.29K | Jun 30, 26 | +196.90K | 0.62% |
| MILLENNIUM MANAGEMENT LLC | 276.73K | Jun 30, 26 | +136.09K | 0.61% |
| Candriam S.C.A. | 233.21K | Jun 30, 26 | -3.60K | 0.52% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 222.95K | Jun 30, 26 | +80.87K | 0.49% |
| Kalehua Capital Management LLC | 197.07K | Jun 30, 26 | -- | 0.44% |
| Longaeva Partners L.P. | 196.35K | Jun 30, 26 | +183.66K | 0.43% |
| Artisan Partners Limited Partnership | 189.50K | Jun 30, 26 | +189.50K | 0.42% |
| Ensign Peak Advisors, Inc | 184.53K | Jun 30, 26 | -71.10K | 0.41% |
| Soleus Capital Management, L.P. | 177.69K | Jun 30, 26 | -115.81K | 0.39% |
| NORTHERN TRUST CORP | 154.48K | Jun 30, 26 | +37.70K | 0.34% |
| MORGAN STANLEY | 151.05K | Jun 30, 26 | +18.02K | 0.33% |
| Sofinnova Investments, Inc. | 144.43K | Jun 30, 26 | +144.43K | 0.32% |
| Qube Research & Technologies Ltd | 140.31K | Jun 30, 26 | +98.07K | 0.31% |
| Alyeska Investment Group, L.P. | 136.22K | Jun 30, 26 | -- | 0.30% |
| GordonMD Global Investments LP | 136.00K | Jun 30, 26 | -- | 0.30% |
| Sixth Street Partners Management Company, L.P. | 129.75K | Jun 30, 26 | +129.75K | 0.29% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129.75K | Jun 30, 26 | +9.50K | 0.29% |
| Sio Capital Management, LLC | 127.81K | Jun 30, 26 | -166.53K | 0.28% |
| Ishara Investments LP | 123.00K | Jun 30, 26 | +73.80K | 0.27% |
| VANGUARD FIDUCIARY TRUST CO | 121.44K | Jun 30, 26 | +9.27K | 0.27% |
| Artia Global Partners LP | 119.74K | Jun 30, 26 | -- | 0.27% |
| UBS Group AG | 116.21K | Jun 30, 26 | -31.43K | 0.26% |
| First Turn Management, LLC | 110.49K | Jun 30, 26 | +110.49K | 0.24% |
| CITIGROUP INC | 110.16K | Jun 30, 26 | +92.11K | 0.24% |
| D. E. Shaw & Co., Inc. | 101.64K | Jun 30, 26 | +101.64K | 0.23% |
| Rock Springs Capital Management LP | 99.43K | Jun 30, 26 | -- | 0.22% |
| Walleye Capital LLC | 97.35K | Jun 30, 26 | +82.25K | 0.22% |
| Rhenman & Partners Asset Management AB | 97.10K | Jun 30, 26 | +9.60K | 0.22% |
| BANK OF AMERICA CORP /DE/ | 88.91K | Jun 30, 26 | +38.04K | 0.20% |
| AMERIPRISE FINANCIAL INC | 82.23K | Jun 30, 26 | +258 | 0.18% |
| Integral Health Asset Management, LLC | 75.00K | Jun 30, 26 | +25.00K | 0.17% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 63.16K | Jun 30, 26 | -77.87K | 0.14% |
| StemPoint Capital LP | 59.43K | Jun 30, 26 | +22.89K | 0.13% |
| DEUTSCHE BANK AG\ | 53.35K | Jun 30, 26 | +40.10K | 0.12% |
| SEVEN GRAND MANAGERS, LLC | 50.00K | Jun 30, 26 | -- | 0.11% |
| Point72 Asset Management, L.P. | 49.33K | Jun 30, 26 | -87.22K | 0.11% |
| TD ASSET MANAGEMENT INC | 47.40K | Jun 30, 26 | -35.60K | 0.10% |
| ALPS ADVISORS INC | 45.52K | Jun 30, 26 | +8.90K | 0.10% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42.48K | Jun 30, 26 | +3.06K | 0.09% |
| Russell Investments Group, Ltd. | 42.26K | Jun 30, 26 | -6.16K | 0.09% |
| Bank of New York Mellon Corp | 41.59K | Jun 30, 26 | +7.81K | 0.09% |
| Nuveen, LLC | 41.26K | Jun 30, 26 | +17.52K | 0.09% |
| XTX Topco Ltd | 38.10K | Jun 30, 26 | +14.54K | 0.08% |
| WELLINGTON MANAGEMENT GROUP LLP | 37.37K | Jun 30, 26 | -8.71K | 0.08% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 35.97K | Jun 30, 26 | +35.97K | 0.08% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35.42K | Jun 30, 26 | -29.04K | 0.08% |
| BNP PARIBAS ARBITRAGE, SNC | 31.80K | Jun 30, 26 | -8.77K | 0.07% |
| Swiss National Bank | 27.00K | Jun 30, 26 | +27.00K | 0.06% |
| Quadrature Capital Ltd | 26.02K | Jun 30, 26 | +26.02K | 0.06% |
| ALLIANCEBERNSTEIN L.P. | 25.45K | Jun 30, 26 | +9.04K | 0.06% |
| Trexquant Investment LP | 23.81K | Jun 30, 26 | +23.81K | 0.05% |
| NEW YORK STATE COMMON RETIREMENT FUND | 23.59K | Jun 30, 26 | +18.29K | 0.05% |
| TUDOR INVESTMENT CORP ET AL | 22.57K | Jun 30, 26 | +22.57K | 0.05% |
| RHUMBLINE ADVISERS | 22.31K | Jun 30, 26 | +4.00K | 0.05% |
| Maven Securities LTD | 20.00K | Jun 30, 26 | -5.00K | 0.04% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18.64K | Jun 30, 26 | +14.53K | 0.04% |
| Susquehanna Portfolio Strategies, LLC | 18.03K | Jun 30, 26 | +18.03K | 0.04% |
| Rafferty Asset Management, LLC | 18.00K | Jun 30, 26 | -4.13K | 0.04% |
| Shay Capital LLC | 18.00K | Jun 30, 26 | +18.00K | 0.04% |
| WELLS FARGO & COMPANY/MN | 16.82K | Jun 30, 26 | +10.93K | 0.04% |
| Engineers Gate Manager LP | 15.60K | Jun 30, 26 | +15.60K | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14.85K | Jun 30, 26 | +13.98K | 0.03% |
| KENNEDY CAPITAL MANAGEMENT LLC | 12.62K | Jun 30, 26 | +337 | 0.03% |
| MARSHALL WACE, LLP | 12.60K | Jun 30, 26 | +12.60K | 0.03% |
| Invesco Ltd. | 12.42K | Jun 30, 26 | +1.63K | 0.03% |
| MetLife Investment Management, LLC | 10.97K | Jun 30, 26 | +2.41K | 0.02% |
| UBS ASSET MANAGEMENT AMERICAS INC | 10.62K | Jun 30, 26 | +10.51K | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10.58K | Jun 30, 26 | +1.40K | 0.02% |
| Jump Financial, LLC | 10.47K | Jun 30, 26 | +10.47K | 0.02% |
| VANGUARD ASSET MANAGEMENT, Ltd | 9.54K | Jun 30, 26 | +9.54K | 0.02% |
| PROFUND ADVISORS LLC | 9.14K | Jun 30, 26 | -799 | 0.02% |
| Virtus Investment Advisers, Inc. | 9.11K | Jun 30, 26 | +2.73K | 0.02% |
| Legal & General Group Plc | 9.04K | Jun 30, 26 | +7.61K | 0.02% |
| Vanguard Global Advisers, LLC | 7.85K | Jun 30, 26 | -3.34K | 0.02% |
| China Universal Asset Management Co., Ltd. | 7.19K | Jun 30, 26 | -734 | 0.02% |
| Quarry LP | 6.75K | Jun 30, 26 | +446 | 0.01% |
| BARCLAYS PLC | 6.50K | Jun 30, 26 | -11.89K | 0.01% |
| VARCOV Co. | 6.42K | Jun 30, 26 | -153 | 0.01% |
| Jupiter Topco LLC | 6.40K | Jun 30, 26 | +6.40K | 0.01% |
| Police & Firemen's Retirement System of New Jersey | 5.44K | Jun 30, 26 | +1.21K | 0.01% |
| Squarepoint Ops LLC | 5.42K | Jun 30, 26 | -9.80K | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | 5.22K | Jun 30, 26 | -271 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 5.21K | Jun 30, 26 | +5.21K | 0.01% |
| SEI INVESTMENTS CO | 5.16K | Jun 30, 26 | +5.16K | 0.01% |
| AlphaCentric Advisors LLC | 4.86K | Jun 30, 26 | +45 | 0.01% |
| Jain Global LLC | 4.78K | Jun 30, 26 | +4.78K | 0.01% |
| AXQ CAPITAL, LP | 4.60K | Jun 30, 26 | +4.60K | 0.01% |
| STRS OHIO | 3.50K | Jun 30, 26 | +600 | 0.01% |
| Vanguard Investments Australia, Ltd. | 3.49K | Jun 30, 26 | +3.49K | 0.01% |
| KLP KAPITALFORVALTNING AS | 3.10K | Jun 30, 26 | +3.10K | 0.01% |
| Mirae Asset Global Investments Co., Ltd. | 2.02K | Jun 30, 26 | -309 | 0.00% |
| Quantbot Technologies LP | 1.82K | Jun 30, 26 | +1.64K | 0.00% |
| Ameritas Investment Partners, Inc. | 1.67K | Jun 30, 26 | +371 | 0.00% |
| Tower Research Capital LLC (TRC) | 1.28K | Jun 30, 26 | -1.07K | 0.00% |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1.00K | Jun 30, 26 | +1.00K | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | 946 | Jun 30, 26 | -57 | 0.00% |
| State of Wyoming | 804 | Jun 30, 26 | +804 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 709 | Jun 30, 26 | +338 | 0.00% |
| ROYAL BANK OF CANADA | 568 | Jun 30, 26 | +538 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | 385 | Jun 30, 26 | +385 | 0.00% |
| Pacer Advisors, Inc. | 301 | Jun 30, 26 | +301 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | 278 | Jun 30, 26 | +278 | 0.00% |
| GAMMA Investing LLC | 244 | Jun 30, 26 | +6 | 0.00% |
| Federation des caisses Desjardins du Quebec | 210 | Jun 30, 26 | +210 | 0.00% |
| Farther Finance Advisors, LLC | 196 | Jun 30, 26 | -- | 0.00% |
| Rockefeller Capital Management L.P. | 114 | Jun 30, 26 | -127 | 0.00% |
| Hurley Capital, LLC | 113 | Jun 30, 26 | +113 | 0.00% |
| US BANCORP \DE\ | 104 | Jun 30, 26 | +53 | 0.00% |
| Sterling Capital Management LLC | 65 | Jun 30, 26 | -40 | 0.00% |
| SRS Capital Advisors, Inc. | 41 | Jun 30, 26 | +41 | 0.00% |
| Bare Financial Services, Inc | 37 | Jun 30, 26 | +37 | 0.00% |
| Caitong International Asset Management Co., Ltd | 31 | Jun 30, 26 | -5 | 0.00% |
| Hughes Financial Services, LLC | 25 | Jun 30, 26 | -1 | 0.00% |
| EverSource Wealth Advisors, LLC | 20 | Jun 30, 26 | -3 | 0.00% |
| Fortitude Family Office, LLC | 15 | Jun 30, 26 | -- | 0.00% |
| Covestor Ltd | 12 | Jun 30, 26 | +12 | 0.00% |
| SJS Investment Consulting Inc. | 9 | Jun 30, 26 | +9 | 0.00% |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 6 | Jun 30, 26 | +6 | 0.00% |
| Integrated Wealth Concepts LLC | 6 | Jun 30, 26 | +6 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | 5 | Jun 30, 26 | -11 | 0.00% |
| Steward Partners Investment Advisory, LLC | 4 | Jun 30, 26 | -250 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | 2 | Jun 30, 26 | +2 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | 1 | Jun 30, 26 | -- | 0.00% |
| Allworth Financial LP | 1 | Jun 30, 26 | -28 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | -- | Jun 30, 26 | -26.77K | -- |
| SIGNATUREFD, LLC | -- | Jun 30, 26 | -24 | -- |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | -- | Jun 30, 26 | -7.31K | -- |
| Hudson Bay Capital Management LP | -- | Jun 30, 26 | -6.18K | -- |
| TWO SIGMA INVESTMENTS, LP | -- | Jun 30, 26 | -5.50K | -- |
| Root Financial Partners, LLC | -- | Jun 30, 26 | -10 | -- |
| Cygnus Capital Advisors, LLC | -- | Jun 30, 26 | -3.80K | -- |
| MAI Capital Management | -- | Jun 30, 26 | -2 | -- |
| ExodusPoint Capital Management, LP | -- | Jun 30, 26 | -7.19K | -- |
| CWM, LLC | 67 | Mar 31, 26 | -13 | 0.00% |
| VANGUARD GROUP INC | 1.18M | Dec 31, 25 | +41.80K | 2.62% |
| CIBC Private Wealth Group, LLC | 4.50K | Dec 31, 25 | +4.50K | 0.01% |