| FMR LLC | 3.94M | Jun 30, 26 | +3.62M | 14.86% |
| Vivo Capital, LLC | 2.50M | Jun 30, 26 | +2.29M | 9.43% |
| BlackRock, Inc. | 1.73M | Jun 30, 26 | +1.71M | 6.51% |
| PERCEPTIVE ADVISORS LLC | 1.70M | Jun 30, 26 | +252.22K | 6.41% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.15M | Jun 30, 26 | +883.70K | 4.32% |
| MILLENNIUM MANAGEMENT LLC | 876.23K | Jun 30, 26 | +342.34K | 3.30% |
| Ikarian Capital, LLC | 787.60K | Jun 30, 26 | -230.00K | 2.97% |
| Candriam S.C.A. | 749.59K | Jun 30, 26 | +749.59K | 2.83% |
| CITADEL ADVISORS LLC | 728.56K | Jun 30, 26 | +576.04K | 2.75% |
| RTW INVESTMENTS, LP | 696.57K | Jun 30, 26 | +326.32K | 2.63% |
| Stonepine Capital Management, LLC | 660.00K | Jun 30, 26 | -315.20K | 2.49% |
| GEODE CAPITAL MANAGEMENT, LLC | 639.54K | Jun 30, 26 | +570.38K | 2.41% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 607.66K | Jun 30, 26 | -2.34M | 2.29% |
| MARSHALL WACE, LLP | 585.58K | Jun 30, 26 | +233.01K | 2.21% |
| BRAIDWELL LP | 584.41K | Jun 30, 26 | +584.41K | 2.20% |
| Point72 Asset Management, L.P. | 556.76K | Jun 30, 26 | +22.80K | 2.10% |
| Velan Capital Investment Management LP | 549.99K | Jun 30, 26 | -33.35K | 2.07% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 540.13K | Jun 30, 26 | -- | 2.04% |
| Woodline Partners LP | 531.25K | Jun 30, 26 | +207.34K | 2.00% |
| STATE STREET CORP | 510.81K | Jun 30, 26 | +481.82K | 1.93% |
| Sofinnova Investments, Inc. | 500.04K | Jun 30, 26 | +395.64K | 1.89% |
| Jupiter Topco LLC | 451.23K | Jun 30, 26 | +451.23K | 1.70% |
| MORGAN STANLEY | 432.22K | Jun 30, 26 | -164.34K | 1.63% |
| Qube Research & Technologies Ltd | 429.89K | Jun 30, 26 | +401.61K | 1.62% |
| Siren, L.L.C. | 427.14K | Jun 30, 26 | -- | 1.61% |
| TWO SIGMA INVESTMENTS, LP | 353.39K | Jun 30, 26 | +284.80K | 1.33% |
| BVF INC/IL | 339.55K | Jun 30, 26 | -- | 1.28% |
| Bank of New York Mellon Corp | 325.30K | Jun 30, 26 | +325.30K | 1.23% |
| Trexquant Investment LP | 321.60K | Jun 30, 26 | +270.89K | 1.21% |
| BOOTHBAY FUND MANAGEMENT, LLC | 311.09K | Jun 30, 26 | -55.70K | 1.17% |
| Logos Global Management LP | 300.00K | Jun 30, 26 | -325.00K | 1.13% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 289.16K | Jun 30, 26 | +260.19K | 1.09% |
| GOLDMAN SACHS GROUP INC | 274.95K | Jun 30, 26 | +243.09K | 1.04% |
| JANE STREET GROUP, LLC | 266.66K | Jun 30, 26 | +233.03K | 1.01% |
| Avidity Partners Management LP | 265.93K | Jun 30, 26 | +50.00K | 1.00% |
| Caption Management, LLC | 255.00K | Jun 30, 26 | +255.00K | 0.96% |
| DIMENSIONAL FUND ADVISORS LP | 253.52K | Jun 30, 26 | +190.73K | 0.96% |
| ADAR1 Capital Management, LLC | 220.46K | Jun 30, 26 | +7.00K | 0.83% |
| NORTHERN TRUST CORP | 199.13K | Jun 30, 26 | +187.09K | 0.75% |
| ExodusPoint Capital Management, LP | 184.50K | Jun 30, 26 | +63.97K | 0.70% |
| Ensign Peak Advisors, Inc | 176.89K | Jun 30, 26 | +176.89K | 0.67% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 168.84K | Jun 30, 26 | +168.84K | 0.64% |
| Integral Health Asset Management, LLC | 167.00K | Jun 30, 26 | -- | 0.63% |
| RENAISSANCE TECHNOLOGIES LLC | 164.00K | Jun 30, 26 | +11.40K | 0.62% |
| Nuveen, LLC | 161.19K | Jun 30, 26 | +161.19K | 0.61% |
| VANGUARD FIDUCIARY TRUST CO | 157.04K | Jun 30, 26 | +123.61K | 0.59% |
| PANAGORA ASSET MANAGEMENT INC | 156.06K | Jun 30, 26 | +156.06K | 0.59% |
| BANK OF AMERICA CORP /DE/ | 136.43K | Jun 30, 26 | +117.86K | 0.51% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 132.27K | Jun 30, 26 | +132.27K | 0.50% |
| Verdad Advisers, LP | 123.17K | Jun 30, 26 | +27.84K | 0.46% |
| SPHERA FUNDS MANAGEMENT LTD. | 120.20K | Jun 30, 26 | -15.81K | 0.45% |
| RAYMOND JAMES FINANCIAL INC | 117.48K | Jun 30, 26 | +117.48K | 0.44% |
| XTX Topco Ltd | 113.77K | Jun 30, 26 | +65.92K | 0.43% |
| Walleye Capital LLC | 105.24K | Jun 30, 26 | +105.24K | 0.40% |
| UBS Group AG | 98.14K | Jun 30, 26 | -283.28K | 0.37% |
| StemPoint Capital LP | 96.27K | Jun 30, 26 | -92.43K | 0.36% |
| WELLINGTON MANAGEMENT GROUP LLP | 95.51K | Jun 30, 26 | +95.51K | 0.36% |
| Creek Drive Management Group LLC | 74.00K | Jun 30, 26 | +29.00K | 0.28% |
| TD ASSET MANAGEMENT INC | 73.15K | Jun 30, 26 | -326.04K | 0.28% |
| FRED ALGER MANAGEMENT, LLC | 71.97K | Jun 30, 26 | +71.97K | 0.27% |
| Sixth Street Partners Management Company, L.P. | 61.17K | Jun 30, 26 | +61.17K | 0.23% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 61.17K | Jun 30, 26 | +61.17K | 0.23% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59.90K | Jun 30, 26 | +15.00K | 0.23% |
| Vestal Point Capital, LP | 53.44K | Jun 30, 26 | -- | 0.20% |
| Man Group plc | 49.04K | Jun 30, 26 | +49.04K | 0.18% |
| BNP PARIBAS ARBITRAGE, SNC | 47.84K | Jun 30, 26 | +17.19K | 0.18% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47.25K | Jun 30, 26 | +15.91K | 0.18% |
| Artia Global Partners LP | 42.08K | Jun 30, 26 | -- | 0.16% |
| Quinn Opportunity Partners LLC | 40.00K | Jun 30, 26 | +40.00K | 0.15% |
| FRANKLIN RESOURCES INC | 35.27K | Jun 30, 26 | +35.27K | 0.13% |
| Squarepoint Ops LLC | 33.33K | Jun 30, 26 | +33.33K | 0.13% |
| RHUMBLINE ADVISERS | 31.29K | Jun 30, 26 | +31.29K | 0.12% |
| ALPS ADVISORS INC | 26.92K | Jun 30, 26 | +26.92K | 0.10% |
| DEUTSCHE BANK AG\ | 24.56K | Jun 30, 26 | +24.56K | 0.09% |
| WELLS FARGO & COMPANY/MN | 21.08K | Jun 30, 26 | +21.08K | 0.08% |
| SummitTX Capital, L.P. | 19.99K | Jun 30, 26 | +19.99K | 0.08% |
| ALLIANCEBERNSTEIN L.P. | 19.90K | Jun 30, 26 | +19.90K | 0.08% |
| MetLife Investment Management, LLC | 14.94K | Jun 30, 26 | +14.94K | 0.06% |
| Verition Fund Management LLC | 13.59K | Jun 30, 26 | -- | 0.05% |
| Invesco Ltd. | 13.10K | Jun 30, 26 | +13.10K | 0.05% |
| CI Private Wealth, LLC | 12.39K | Jun 30, 26 | -- | 0.05% |
| Vanguard Global Advisers, LLC | 12.11K | Jun 30, 26 | +8.81K | 0.05% |
| CITIGROUP INC | 11.62K | Jun 30, 26 | +11.62K | 0.04% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11.54K | Jun 30, 26 | +11.54K | 0.04% |
| Quantbot Technologies LP | 10.73K | Jun 30, 26 | +10.73K | 0.04% |
| LETKO, BROSSEAU & ASSOCIATES INC | 10.65K | Jun 30, 26 | -- | 0.04% |
| JPMORGAN CHASE & CO | 10.51K | Jun 30, 26 | +1.09K | 0.04% |
| SEI INVESTMENTS CO | 10.11K | Jun 30, 26 | +10.11K | 0.04% |
| Diversified Trust Co | 10.02K | Jun 30, 26 | +10.02K | 0.04% |
| K2 PRINCIPAL FUND, L.P. | 10.00K | Jun 30, 26 | +10.00K | 0.04% |
| NEW YORK STATE COMMON RETIREMENT FUND | 8.80K | Jun 30, 26 | +8.80K | 0.03% |
| BARCLAYS PLC | 8.05K | Jun 30, 26 | -8.64K | 0.03% |
| Police & Firemen's Retirement System of New Jersey | 7.42K | Jun 30, 26 | +7.42K | 0.03% |
| STRS OHIO | 4.90K | Jun 30, 26 | +4.90K | 0.02% |
| China Universal Asset Management Co., Ltd. | 3.60K | Jun 30, 26 | +3.60K | 0.01% |
| Legal & General Group Plc | 2.44K | Jun 30, 26 | +2.44K | 0.01% |
| Tower Research Capital LLC (TRC) | 2.31K | Jun 30, 26 | +1.21K | 0.01% |
| Ameritas Investment Partners, Inc. | 2.29K | Jun 30, 26 | +2.29K | 0.01% |
| Russell Investments Group, Ltd. | 2.05K | Jun 30, 26 | +2.05K | 0.01% |
| ROYAL BANK OF CANADA | 776 | Jun 30, 26 | +776 | 0.00% |
| Sterling Capital Management LLC | 507 | Jun 30, 26 | +507 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | 500 | Jun 30, 26 | +500 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 347 | Jun 30, 26 | +347 | 0.00% |
| Quarry LP | 192 | Jun 30, 26 | +192 | 0.00% |
| Caitong International Asset Management Co., Ltd | 150 | Jun 30, 26 | +93 | 0.00% |
| SBI Securities Co., Ltd. | 57 | Jun 30, 26 | +57 | 0.00% |
| Commonwealth Retirement Investments LLC | 2 | Jun 30, 26 | +2 | 0.00% |
| Allworth Financial LP | 1 | Jun 30, 26 | -- | 0.00% |
| Rockefeller Capital Management L.P. | 1 | Jun 30, 26 | -2.50K | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | 1 | Jun 30, 26 | -- | 0.00% |
| Physician Wealth Advisors, Inc. | 1 | Jun 30, 26 | -- | 0.00% |
| Union Bancaire Privee, UBP SA | 1 | Jun 30, 26 | -- | 0.00% |
| Titiun Yejiel | -- | Jun 30, 26 | -1 | -- |
| ACADIAN ASSET MANAGEMENT LLC | -- | Jun 30, 26 | -4.50K | -- |
| HRT FINANCIAL LP | -- | Jun 30, 26 | -41.82K | -- |
| BOONE CAPITAL MANAGEMENT LLC | -- | Jun 30, 26 | -200.00K | -- |
| DIADEMA PARTNERS LP | -- | Jun 30, 26 | -179.74K | -- |
| AMERIPRISE FINANCIAL INC | -- | Jun 30, 26 | -279.54K | -- |
| BALYASNY ASSET MANAGEMENT L.P. | -- | Jun 30, 26 | -194.62K | -- |
| VR Adviser, LLC | -- | Jun 30, 26 | -1.68M | -- |
| GREAT POINT PARTNERS LLC | -- | Jun 30, 26 | -327.31K | -- |
| ARMISTICE CAPITAL, LLC | -- | Jun 30, 26 | -478.83K | -- |
| MAI Capital Management | -- | Jun 30, 26 | -1 | -- |
| Persistent Asset Partners Ltd | -- | Jun 30, 26 | -58.18K | -- |
| Quadrature Capital Ltd | -- | Jun 30, 26 | -15.47K | -- |
| Janus Henderson Group Ltd. | 1.82M | Mar 31, 26 | +1.65M | 6.84% |
| Deeter Investments LLP | 100.00K | Mar 31, 26 | -- | 0.38% |
| VANGUARD GROUP INC | 255.66K | Dec 31, 25 | +93.86K | 0.96% |
| TWO SIGMA ADVISERS, LP | 13.18K | Dec 31, 25 | +13.18K | 0.05% |
| BlackRock Inc. | 300 | Jun 30, 24 | -- | 0.00% |
| GOFEN & GLOSSBERG LLC /IL/ | -- | Dec 31, 22 | -3.82M | -- |
| WIPFLI FINANCIAL ADVISORS LLC, | 1 | Sep 30, 22 | +1 | 0.00% |
| LADENBURG THALMANN FINANCIAL SERVICES INC. | 5.02K | Dec 31, 19 | -- | 0.02% |
| Advisor Group, Inc. | 3.06K | Dec 31, 19 | -- | 0.01% |