CDXS
Next earnings: Aug 12, 2026 · After close
Signal
Mixed11
Price
1
Move-4.28%Selling pressure
Volume
1
Volume0.3× avgLight volume
Technical
1
RSIRSI 61Momentum positive
PRICE
Prev Close
2.57
Open
2.50
Day Range2.40 – 2.54
2.40
2.54
52W Range0.96 – 3.87
0.96
3.87
52% of range
VOLUME & SIZE
Avg Volume
2.3M
FUNDAMENTALS
P/E Ratio
-7.0x
Not profitable
EPS (TTM)
Div Yield
No dividend
Beta
1.79
High vol
Performance
1D
-4.28%
5D
-5.38%
1M
3M
+105.00%
6M
+49.09%
YTD
+50.92%
1Y
-1.99%
Best: 3M (+105.00%)Worst: 5D (-5.38%)
Quick Read
TrendInsufficient MA data
Momentum
BULLISH
revenue +57% YoY · 84% gross margin
Valuation
FAIR
P/E not available
Health
WEAK
CR 5.4 · FCF negative
Lean Bullish
Key MetricsTTM
Market Cap$223.61M
Revenue TTM$78.09M
Net Income TTM-$31.99M
Free Cash Flow-$22.12M
Gross Margin83.9%
Net Margin-41.0%
Operating Margin-33.2%
Return on Equity-68.1%
Return on Assets-24.7%
Debt / Equity1.69
Current Ratio5.36
EPS TTM$-0.35
Alpha SignalsFull Analysis →
What Moves This Stock

Announcements of new pharmaceutical collaboration agreements or contract wins, particularly with top-20 pharma companies

Progress updates on key customer programs transitioning from development to commercial manufacturing scale

Quarterly product revenue trends indicating adoption of existing enzyme products in commercial pharmaceutical production

Cash runway updates and financing announcements given negative $10M operating cash flow and potential need for capital raise

Macro Sensitivity
Economic Cycle

low - Pharmaceutical manufacturing is relatively recession-resistant as drug production continues regardless of economic conditions. However, biotech customer funding for R&D collaborations is moderately cyclical, as venture capital and IPO markets for biotech partners dry up during downturns. The company's revenue decline appears driven by company-specific execution issues rather than macro factors, though tighter biotech financing conditions in 2024-2025 likely contributed to collaboration revenue weakness.

Interest Rates

Rising interest rates have moderate negative impact through two channels: (1) higher discount rates compress valuation multiples for unprofitable biotech companies, particularly those trading at 2.0x sales with negative cash flow; (2) tighter financial conditions reduce venture funding for biotech customers who might otherwise sign R&D collaboration agreements. However, the company's own financing costs are minimal given low debt levels (1.78 debt/equity but small absolute debt given $100M market cap). The 4.12 current ratio suggests adequate near-term liquidity, but sustained high rates could pressure the company's ability to raise growth capital on favorable terms.

Key Risks

Technological obsolescence risk if competing enzyme engineering platforms (machine learning-based protein design from companies like Arzeda, Evonetix) or alternative synthesis methods (continuous flow chemistry, AI-designed small molecule routes) prove superior or more cost-effective

Pharmaceutical industry consolidation reducing the number of potential customers and increasing buyer negotiating power, particularly as top 10 pharma companies represent estimated 60-70% of addressable market

Regulatory changes requiring more extensive validation data for biocatalytic manufacturing processes, increasing customer adoption barriers and lengthening sales cycles

Investor Profile

growth - The company attracts speculative biotech investors betting on platform technology adoption and eventual profitability inflection, despite current negative cash flow and revenue decline. The 73% one-year decline and -61% six-month return indicate momentum investors have abandoned the stock. Value investors are deterred by negative earnings, cash burn, and lack of clear path to profitability. This is a high-risk, high-potential-reward profile suitable only for investors with biotech sector expertise and tolerance for binary outcomes (successful platform adoption versus potential bankruptcy/acquisition).

Watch on Earnings
Quarterly product revenue run-rate and year-over-year growth to assess whether 15% revenue decline is stabilizing or acceleratingNumber of active pharmaceutical collaborations and average contract value to gauge pipeline healthCash balance and quarterly operating cash flow burn rate to estimate financing runwayGross margin percentage to detect pricing pressure or manufacturing cost inflation
Health Radar
2 strong1 watch3 concern
41/100
Liquidity
5.36Strong
Leverage
1.69Watch
Coverage
-20.0xConcern
ROE
-68.1%Concern
ROIC
-22.0%Concern
Cash
$51MStrong
ANALYST COVERAGE14 analysts
BUY
+103.3%upside to target
Buy
964%
Hold
536%
9 Buy (64%)5 Hold (36%)0 Sell (0%)
Full report →
Stock Health
Composite Score
4 of 5 signals bullish
7/10
Technicals
RSI RangeRSI 61 — Bullish momentum
Volume
Volume FlowDistribution — institutional selling
Fundamentals
Last EarningsBeat estimates
Analyst ConsensusBuy
LiquidityCurrent Ratio 5.36 — healthy liquidity
Upcoming Events
EEarnings Report · Before OpenMay 17, 2026
Tomorrow
DEx-Dividend DateAug 14, 2026
In 90 days
PDividend PaymentAug 17, 2026
In 93 days
Technicals
Technical SetupBULLISH
Technicals →

Trend

UptrendDeath Cross · 50D trails 200D by 16.3%

+41.3% vs SMA 50 · +18.2% vs SMA 200

Momentum

RSI61.2
Positive momentum, not extended
MACD+0.24
Above zero — bullish momentum · compressing
Market Position
Price Levels
52W High
$3.87+57.3%
Current
$2.46
EMA 200
$2.12-13.6%
EMA 50
$2.00-18.7%
52W Low
$0.9600-61.0%
52-Week RangeMid-range
$0.960052th %ile$3.87
Squeeze SetupVolume-based
Distribution Pressure

Distribution pattern detected. More selling days than accumulation over the past 20 sessions. Not a conducive environment for a squeeze.

20-Day Money Flow
Acc days:0
Dist days:0
Edge:Even
Volume Context
Avg Vol (50D)2.5M
Recent Vol (5D)
961K-61%

Based on volume distribution analysis. Direct short interest data (short float %, days to cover) is not available in current data sources.

Earnings & Analysts

ANALYST ESTIMATES

Consensus of 5 analysts
Analyst revisions:EPS↓ Revised DownRevenue↓ Revised Down

Analyst consensus estimates · Actuals replace estimates as reported

YearRevenue Est.Rev GthEPS Est.EPS GthRangeAnalysts
FY2025
$67.3M
$61.3M$73.3M
-$0.64
±8%
High5
FY2026(current)
$74.1M
$69.7M$83.2M
+10.1%-$0.40
±14%
Moderate4
FY2027
$88.9M
$79.4M$106.7M
+20.1%-$0.29
±50%
Moderate4
Range confidence:Tight (high)ModerateWide (low)
Earnings HistoryCDXS
Last 8Q
+84.9%avg beat
Beat 3 of 8 quartersMissed 5 Estimates rising
-23%
Q3'24
-16%
Q4'24
-225%
Q1'25
-25%
Q2'25
+6%
Q3'25
-47%
Q4'25
+1000%
Q1'26
+9%
Q2'26
Beat
Miss
Estimate
Deeper color = bigger beat/miss
* Negative EPS shown at reduced height
Analyst Activity
All ratings →
No recent activity
BenchmarkPositive → Hold
Aug 19
DOWNGRADE
BenchmarkPositive
Feb 29
UPGRADE
Insider Activity
SEC Filings →
0 Buys/6 SellsNet Selling
Lutz StefanChief Scientif…
$7K
Feb 24
SELL
Lutz StefanChief Scientif…
$3K
Feb 6
SELL
Erbez GeorgiaSee Remarks
$5K
Feb 6
SELL
Moore AlisonDir
$5K
Feb 6
SELL
Lutz StefanCSO
$8K
Jan 7
SELL
Opaleye Management …10 Percent Own…
$258K
Nov 26
SELL
Financials

INSTITUTIONAL OWNERSHIP

1
abrdn plc
8.7M
2
BlackRock, Inc.
7.0M
3
Opaleye Management Inc.
6.8M
4
Nantahala Capital Management, LLC
4.1M
5
MILLENNIUM MANAGEMENT LLC
4.0M
6
Telemark Asset Management, LLC
3.8M
7
AMERIPRISE FINANCIAL INC
3.4M
8
UBS Group AG
2.2M
News & Activity

CDXS News

20 articles · 4h ago

About

codexis, inc. is a leading protein engineering company applying innovative technologies to unlock the power of proteins™. our proprietary codeevolver® technology platform enables the rapid development and production of highly optimized proteins, custom-designed for your application. codexis’ revolutionary approach to protein engineering starts with an understanding of the desired performance specifications and optimizes a protein specifically to fit these requirements. you get precisely the protein you need for the job you want it to do. guided by proprietary artificial intelligence software and advanced high-throughput screening systems, codexis is able to efficiently generate and introduce function-driven mutations to rapidly improve a protein for its target application. since 2002, codexis’ in-house biochemists, biologists and bioinformatics experts have worked closely with our clients to advance the technologies for protein optimization and production, enabling breakthrough develop

Industry
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
Karen Frechou-ArmijoSenior Vice President & Head of Human Resources
Alison MoorePresident, Chief Executive Officer & Director
Britton JimenezSenior Vice President of Sales & Marketing
PeersHealth Care(7 companies)
Screen sector →
SymbolPriceDay %Mkt CapP/ERev GrwMarginELO
CDXS
$2.46-4.28%$224M+1860.6%-6247.5%1500
$66.13-5.07%$13.0B+12626.1%-14525.8%1500
$94.92-3.79%$12.6B+3288.2%-4239.0%1500
$523.69-3.00%$12.1B+43205.3%-3008.0%1500
$227.72-1.30%$11.7B+6554.5%-2868.8%1500
$57.90-0.86%$11.2B50.3+1459.3%147.7%1500
$76.67-3.79%$10.8B+2325815.3%-19.7%1500
Sector avg-3.15%50.3+342115.6%-4394.4%1500