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Institutional Ownership

Top 239 Institutional Holders
HolderSharesDateChange% Held
Frazier Life Sciences Management, L.P.4.57MMar 31, 26--8.25%
TRV GP IV, LLC4.47MMar 31, 26--8.08%
ARCH Venture Management, LLC4.12MMar 31, 26--7.44%
Deep Track Capital, LP3.48MMar 31, 26-768.88K6.28%
JANUS HENDERSON GROUP PLC2.86MMar 31, 26-283.71K5.17%
Paradigm Biocapital Advisors LP2.74MMar 31, 26+2.74M4.96%
BlackRock, Inc.2.57MMar 31, 26+283.27K4.64%
AH Capital Management, L.L.C.1.70MMar 31, 26--3.08%
VR Adviser, LLC1.60MMar 31, 26+53.47K2.89%
Alphabet Inc.1.39MMar 31, 26--2.51%
Logos Global Management LP1.24MMar 31, 26+285.00K2.23%
ADAGE CAPITAL PARTNERS GP, L.L.C.1.18MMar 31, 26+1.18M2.13%
General Catalyst Group Management, LLC1.04MMar 31, 26--1.87%
TRV GP V, LLC950.80KMar 31, 26--1.72%
FMR LLC864.21KMar 31, 26+135.61K1.56%
CITADEL ADVISORS LLC775.71KMar 31, 26+327.50K1.40%
ArrowMark Colorado Holdings LLC767.38KMar 31, 26--1.39%
Casdin Capital, LLC758.86KMar 31, 26--1.37%
Cormorant Asset Management, LP750.00KMar 31, 26+750.00K1.36%
Woodline Partners LP650.23KMar 31, 26-385.00K1.17%
STATE STREET CORP636.72KMar 31, 26+103.72K1.15%
DRIEHAUS CAPITAL MANAGEMENT LLC636.16KMar 31, 26+258.15K1.15%
Caligan Partners LP614.96KMar 31, 26+64.77K1.11%
GEODE CAPITAL MANAGEMENT, LLC599.97KMar 31, 26+72.69K1.08%
BESSEMER GROUP INC481.79KMar 31, 26--0.87%
BALYASNY ASSET MANAGEMENT L.P.461.15KMar 31, 26+261.94K0.83%
Ikarian Capital, LLC379.00KMar 31, 26-265.68K0.68%
FARALLON CAPITAL MANAGEMENT LLC373.00KMar 31, 26+373.00K0.67%
HHLR ADVISORS, LTD.366.03KMar 31, 26-91.51K0.66%
MARSHALL WACE, LLP310.64KMar 31, 26-536.83K0.56%
BOOTHBAY FUND MANAGEMENT, LLC284.48KMar 31, 26-124.90K0.51%
WASHINGTON UNIVERSITY280.80KMar 31, 26--0.51%
GOLDMAN SACHS GROUP INC279.71KMar 31, 26+165.26K0.51%
Candriam S.C.A.278.17KMar 31, 26+278.17K0.50%
Mass General Brigham, Inc239.99KMar 31, 26--0.43%
Freestone Grove Partners LP234.95KMar 31, 26+116.08K0.42%
SPHERA FUNDS MANAGEMENT LTD.227.34KMar 31, 26+155.50K0.41%
abrdn plc226.23KMar 31, 26+226.23K0.41%
NORTHERN TRUST CORP211.38KMar 31, 26+35.12K0.38%
MORGAN STANLEY204.83KMar 31, 26-53.26K0.37%
CHARLES SCHWAB INVESTMENT MANAGEMENT INC186.43KMar 31, 26+10.46K0.34%
Ensign Peak Advisors, Inc185.79KMar 31, 26--0.34%
Foresite Capital Management IV, LLC156.90KMar 31, 26-365.76K0.28%
VANGUARD FIDUCIARY TRUST CO151.00KMar 31, 26+151.00K0.27%
Holocene Advisors, LP136.17KMar 31, 26+136.17K0.25%
Qube Research & Technologies Ltd134.95KMar 31, 26+134.95K0.24%
PRICE T ROWE ASSOCIATES INC /MD/122.69KMar 31, 26+6.98K0.22%
Atika Capital Management LLC111.50KMar 31, 26+111.50K0.20%
AMERIPRISE FINANCIAL INC107.49KMar 31, 26+10.80K0.19%
Alyeska Investment Group, L.P.100.00KMar 31, 26-96.12K0.18%
Integral Health Asset Management, LLC100.00KMar 31, 26--0.18%
HighVista Strategies LLC99.85KMar 31, 26-70.50K0.18%
UBS Group AG93.90KMar 31, 26+65.20K0.17%
Exome Asset Management LLC88.51KMar 31, 26+88.51K0.16%
Invesco Ltd.86.42KMar 31, 26-47.61K0.16%
SummitTX Capital, L.P.83.75KMar 31, 26+14.19K0.15%
Bank of New York Mellon Corp74.27KMar 31, 26+13.83K0.13%
RAYMOND JAMES FINANCIAL INC69.38KMar 31, 26+1.66K0.13%
ALLIANCEBERNSTEIN L.P.64.76KMar 31, 26+31.54K0.12%
Nuveen, LLC63.36KMar 31, 26+6.10K0.11%
WELLINGTON MANAGEMENT GROUP LLP60.59KMar 31, 26-6180.11%
ADVISOR GROUP HOLDINGS, INC.59.94KMar 31, 26+1810.11%
FRANKLIN RESOURCES INC59.64KMar 31, 26+4.41K0.11%
JPMORGAN CHASE & CO58.45KMar 31, 26+38.44K0.11%
D. E. Shaw & Co., Inc.45.64KMar 31, 26+11.94K0.08%
Propel Bio Management, LLC43.80KMar 31, 26+43.80K0.08%
ALPS ADVISORS INC39.17KMar 31, 26+39.17K0.07%
SCHRODER INVESTMENT MANAGEMENT GROUP37.18KMar 31, 26+37.18K0.07%
DAFNA Capital Management LLC35.00KMar 31, 26+35.00K0.06%
Aquatic Capital Management LLC34.98KMar 31, 26+34.98K0.06%
Russell Investments Group, Ltd.32.53KMar 31, 26+9.98K0.06%
Parkman Healthcare Partners LLC31.84KMar 31, 26-177.42K0.06%
RHUMBLINE ADVISERS31.51KMar 31, 26+7.78K0.06%
TWINBEECH CAPITAL LP30.99KMar 31, 26+30.99K0.06%
MILLENNIUM MANAGEMENT LLC29.89KMar 31, 26-124.58K0.05%
AQR CAPITAL MANAGEMENT LLC27.95KMar 31, 26+5060.05%
Walleye Capital LLC27.95KMar 31, 26+27.95K0.05%
XTX Topco Ltd26.85KMar 31, 26-6.17K0.05%
Foresite Capital Management V, LLC25.91KMar 31, 26-60.39K0.05%
FIRST TRUST ADVISORS LP25.48KMar 31, 26+25.48K0.05%
SUSQUEHANNA INTERNATIONAL GROUP, LLP25.30KMar 31, 26+25.30K0.05%
Blackstone Inc.24.99KMar 31, 26+24.99K0.05%
Y-Intercept (Hong Kong) Ltd21.73KMar 31, 26+21.73K0.04%
DEUTSCHE BANK AG\20.26KMar 31, 26+4.74K0.04%
ACUTA CAPITAL PARTNERS, LLC19.34KMar 31, 26-6650.03%
Verition Fund Management LLC19.13KMar 31, 26-3.38K0.03%
PRELUDE CAPITAL MANAGEMENT, LLC18.13KMar 31, 26+18.13K0.03%
Caitong International Asset Management Co., Ltd17.78KMar 31, 26+14.28K0.03%
GILDER GAGNON HOWE & CO LLC17.49KMar 31, 26-5.79K0.03%
TWO SIGMA INVESTMENTS, LP15.85KMar 31, 26+8.60K0.03%
RENAISSANCE TECHNOLOGIES LLC15.80KMar 31, 26-11.30K0.03%
Vanguard Global Advisers, LLC15.20KMar 31, 26+15.20K0.03%
Engineers Gate Manager LP15.11KMar 31, 26+15.11K0.03%
DIADEMA PARTNERS LP15.00KMar 31, 26+15.00K0.03%
MANUFACTURERS LIFE INSURANCE COMPANY, THE14.57KMar 31, 26+7.67K0.03%
MetLife Investment Management, LLC14.54KMar 31, 26+2.74K0.03%
Squarepoint Ops LLC13.61KMar 31, 26+13.61K0.02%
Ground Swell Capital, LLC13.61KMar 31, 26+13.61K0.02%
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.12.42KMar 31, 26-18.88K0.02%
China Universal Asset Management Co., Ltd.11.99KMar 31, 26+5540.02%
WELLS FARGO & COMPANY/MN10.37KMar 31, 26-13.64K0.02%
Falcon Wealth Planning9.64KMar 31, 26-3910.02%
AMERICAN CENTURY COMPANIES INC9.63KMar 31, 26-11.87K0.02%
INTECH INVESTMENT MANAGEMENT LLC9.52KMar 31, 26+3.08K0.02%
LOS ANGELES CAPITAL MANAGEMENT LLC9.42KMar 31, 26-9.68K0.02%
BARCLAYS PLC9.26KMar 31, 26-30.25K0.02%
CAPSTONE INVESTMENT ADVISORS, LLC9.14KMar 31, 26+9.14K0.02%
IFP Advisors, Inc8.99KMar 31, 26+5.47K0.02%
Persistent Asset Partners Ltd8.77KMar 31, 26+2.16K0.02%
CITIGROUP INC8.56KMar 31, 26-2.69K0.02%
NEW YORK STATE COMMON RETIREMENT FUND8.20KMar 31, 26+1.50K0.01%
Hudson Bay Capital Management LP8.15KMar 31, 26+8.15K0.01%
Voleon Capital Management LP7.29KMar 31, 26+7.29K0.01%
Police & Firemen's Retirement System of New Jersey7.10KMar 31, 26+1.14K0.01%
AXQ CAPITAL, LP7.09KMar 31, 26+7.09K0.01%
Virtus Investment Advisers, Inc.7.02KMar 31, 26+1700.01%
MANGROVE PARTNERS6.75KMar 31, 26+6.75K0.01%
BNP PARIBAS ARBITRAGE, SNC6.47KMar 31, 26+1.00K0.01%
STRS OHIO6.30KMar 31, 26-4.90K0.01%
Legal & General Group Plc5.79KMar 31, 26+4110.01%
Caption Management, LLC5.00KMar 31, 26+5.00K0.01%
Tower Research Capital LLC (TRC)2.78KMar 31, 26+1.43K0.01%
Mirae Asset Global Investments Co., Ltd.2.51KMar 31, 26+1720.00%
Ameritas Investment Partners, Inc.2.17KMar 31, 26+5330.00%
CWM, LLC2.14KMar 31, 26-860.00%
ROYAL BANK OF CANADA2.03KMar 31, 26+1.38K0.00%
EverSource Wealth Advisors, LLC1.73KMar 31, 26+1.58K0.00%
NISA INVESTMENT ADVISORS, LLC1.40KMar 31, 26+1.20K0.00%
SIMPLEX TRADING, LLC1.21KMar 31, 26+1.21K0.00%
FEDERATED HERMES, INC.1.10KMar 31, 26+1.10K0.00%
GF FUND MANAGEMENT CO. LTD.1.08KMar 31, 26+1360.00%
Sterling Capital Management LLC829Mar 31, 26-3320.00%
UBS ASSET MANAGEMENT AMERICAS INC427Mar 31, 26+3280.00%
Zurcher Kantonalbank (Zurich Cantonalbank)361Mar 31, 26+3610.00%
Farther Finance Advisors, LLC359Mar 31, 26--0.00%
GAMMA Investing LLC352Mar 31, 26+1800.00%
Kemnay Advisory Services Inc.306Mar 31, 26+3060.00%
SIGNATUREFD, LLC169Mar 31, 26+1550.00%
JONES FINANCIAL COMPANIES LLLP90Mar 31, 26--0.00%
PNC FINANCIAL SERVICES GROUP, INC.58Mar 31, 26--0.00%
ROTHSCHILD INVESTMENT LLC20Mar 31, 26+100.00%
Allworth Financial LP14Mar 31, 26+90.00%
US BANCORP \DE\9Mar 31, 26-320.00%
Larson Financial Group LLC6Mar 31, 26+60.00%
SBI Securities Co., Ltd.6Mar 31, 26-610.00%
MAI Capital Management5Mar 31, 26+50.00%
True Wealth Design, LLC5Mar 31, 26--0.00%
QUADRANT CAPITAL GROUP LLC4Mar 31, 26+40.00%
Stone House Investment Management, LLC2Mar 31, 26+20.00%
Hughes Financial Services, LLC1Mar 31, 26+10.00%
TUDOR INVESTMENT CORP ET AL--Mar 31, 26-24.06K--
SG Americas Securities, LLC--Mar 31, 26-8.49K--
Trexquant Investment LP--Mar 31, 26-52.46K--
Brevan Howard Capital Management LP--Mar 31, 26-5.04K--
SEVEN GRAND MANAGERS, LLC--Mar 31, 26-50.00K--
TCG Crossover Management, LLC--Mar 31, 26-173.82K--
PROFUND ADVISORS LLC--Mar 31, 26-6.02K--
ProShare Advisors LLC--Mar 31, 26-6.05K--
WestHill Financial Advisors, Inc.--Mar 31, 26-5.19K--
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.--Mar 31, 26-6.05K--
EVENTIDE ASSET MANAGEMENT, LLC--Mar 31, 26-324.04K--
StemPoint Capital LP--Mar 31, 26-125.88K--
Cinctive Capital Management LP--Mar 31, 26-29.13K--
Schonfeld Strategic Advisors LLC--Mar 31, 26-48.20K--
SEI INVESTMENTS CO--Mar 31, 26-5.67K--
Bellevue Group AG--Mar 31, 26-887.71K--
Matrix Capital Management Company, LP--Mar 31, 26-480.00K--
Rafferty Asset Management, LLC--Mar 31, 26-5.24K--
AMALGAMATED BANK--Mar 31, 26-674--
BioImpact Capital LLC--Mar 31, 26-81.14K--
Daiwa Securities Group Inc.--Mar 31, 26-160--
Quantbot Technologies LP--Mar 31, 26-5.22K--
Frazier Life Sciences Management, L.P.4.57MDec 31, 25--8.25%
ARCH Venture Management, LLC4.12MDec 31, 25--7.44%
JANUS HENDERSON GROUP PLC3.14MDec 31, 25+2.39M5.68%
AH Capital Management, L.L.C.1.70MDec 31, 25--3.08%
VANGUARD GROUP INC1.70MDec 31, 25+362.06K3.07%
VR Adviser, LLC1.55MDec 31, 25+317.80K2.80%
General Catalyst Group Management, LLC1.04MDec 31, 25--1.87%
Woodline Partners LP1.04MDec 31, 25--1.87%
Logos Global Management LP950.00KDec 31, 25-277.30K1.72%
Bellevue Group AG887.71KDec 31, 25+887.71K1.60%
ArrowMark Colorado Holdings LLC767.38KDec 31, 25+222.25K1.39%
Casdin Capital, LLC758.86KDec 31, 25--1.37%
FMR LLC728.61KDec 31, 25+72.99K1.32%
Ikarian Capital, LLC644.68KDec 31, 25-96.14K1.16%
Caligan Partners LP550.19KDec 31, 25+550.19K0.99%
HHLR ADVISORS, LTD.457.54KDec 31, 25--0.83%
CITADEL ADVISORS LLC448.22KDec 31, 25+448.22K0.81%
BOOTHBAY FUND MANAGEMENT, LLC409.37KDec 31, 25+57.50K0.74%
DRIEHAUS CAPITAL MANAGEMENT LLC378.01KDec 31, 25--0.68%
EVENTIDE ASSET MANAGEMENT, LLC324.04KDec 31, 25+324.04K0.59%
MORGAN STANLEY258.09KDec 31, 25+45.32K0.47%
Parkman Healthcare Partners LLC209.27KDec 31, 25+9.27K0.38%
BALYASNY ASSET MANAGEMENT L.P.199.21KDec 31, 25-234.51K0.36%
ADAR1 Capital Management, LLC179.53KDec 31, 25+153.49K0.32%
NORTHERN TRUST CORP176.26KDec 31, 25-6310.32%
TCG Crossover Management, LLC173.82KDec 31, 25+173.82K0.31%
HighVista Strategies LLC170.35KDec 31, 25+170.35K0.31%
StemPoint Capital LP125.88KDec 31, 25+125.88K0.23%
Freestone Grove Partners LP118.88KDec 31, 25+118.88K0.21%
PRICE T ROWE ASSOCIATES INC /MD/115.71KDec 31, 25+105.24K0.21%
GOLDMAN SACHS GROUP INC114.45KDec 31, 25+114.45K0.21%
Integral Health Asset Management, LLC100.00KDec 31, 25+100.00K0.18%
AMERIPRISE FINANCIAL INC96.69KDec 31, 25+96.69K0.17%
Foresite Capital Management V, LLC86.29KDec 31, 25--0.16%
SPHERA FUNDS MANAGEMENT LTD.71.84KDec 31, 25-82.50K0.13%
SummitTX Capital, L.P.69.56KDec 31, 25+69.56K0.13%
RAYMOND JAMES FINANCIAL INC67.72KDec 31, 25+67.72K0.12%
WELLINGTON MANAGEMENT GROUP LLP61.20KDec 31, 25+61.20K0.11%
Trexquant Investment LP52.46KDec 31, 25+52.46K0.09%
BARCLAYS PLC39.51KDec 31, 25+11.99K0.07%
D. E. Shaw & Co., Inc.33.69KDec 31, 25+33.69K0.06%
ALLIANCEBERNSTEIN L.P.33.22KDec 31, 25-26.88K0.06%
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.31.30KDec 31, 25+22.22K0.06%
Cinctive Capital Management LP29.13KDec 31, 25+29.13K0.05%
AQR CAPITAL MANAGEMENT LLC27.44KDec 31, 25-1760.05%
GILDER GAGNON HOWE & CO LLC23.28KDec 31, 25+23.28K0.04%
Verition Fund Management LLC22.51KDec 31, 25+22.51K0.04%
AMERICAN CENTURY COMPANIES INC21.51KDec 31, 25+21.51K0.04%
ACUTA CAPITAL PARTNERS, LLC20.00KDec 31, 25+20.00K0.04%
BANK OF AMERICA CORP /DE/18.38KDec 31, 25+8.81K0.03%
TWO SIGMA ADVISERS, LP14.80KDec 31, 25+14.80K0.03%
CIBC Private Wealth Group, LLC5.40KDec 31, 25+5.40K0.01%
Rafferty Asset Management, LLC5.24KDec 31, 25+5.24K0.01%
Brevan Howard Capital Management LP5.04KDec 31, 25+5.04K0.01%
CWM, LLC2.23KDec 31, 25+910.00%
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM1.32KDec 31, 25+7660.00%
JONES FINANCIAL COMPANIES LLLP90Dec 31, 25+900.00%
SageView Advisory Group, LLC54Dec 31, 25+540.00%
US BANCORP \DE\41Dec 31, 25+410.00%
Sunbelt Securities, Inc.12Dec 31, 25--0.00%
Allworth Financial LP5Dec 31, 25+50.00%
Nantahala Capital Management, LLC--Dec 31, 25-93.35K--
Caption Management, LLC--Dec 31, 25-4.00K--
SRS Capital Advisors, Inc.--Dec 31, 25-307--
HARVARD MANAGEMENT CO INC--Dec 31, 25-92.40K--
Octagon Capital Advisors LP--Dec 31, 25-177.67K--
Congress Wealth Management LLC / DE /30.23KJun 30, 25+30.23K0.05%

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