| TCG Crossover Management, LLC | 1.47M | Jun 30, 26 | -- | 19.70% |
| Boxer Capital Management, LLC | 1.11M | Jun 30, 26 | +339.37K | 14.79% |
| MILLENNIUM MANAGEMENT LLC | 683.08K | Jun 30, 26 | -48.06K | 9.14% |
| Point72 Asset Management, L.P. | 664.27K | Jun 30, 26 | +664.27K | 8.88% |
| VR Adviser, LLC | 632.93K | Jun 30, 26 | -- | 8.46% |
| StemPoint Capital LP | 602.80K | Jun 30, 26 | +77.16K | 8.06% |
| PERCEPTIVE ADVISORS LLC | 503.99K | Jun 30, 26 | +274.59K | 6.74% |
| Spruce Street Capital LP | 432.04K | Jun 30, 26 | -- | 5.78% |
| BlackRock, Inc. | 394.86K | Jun 30, 26 | +367.01K | 5.28% |
| VANGUARD CAPITAL MANAGEMENT LLC | 392.55K | Jun 30, 26 | +223.46K | 5.25% |
| BRAIDWELL LP | 390.75K | Jun 30, 26 | -5.35K | 5.23% |
| Kalehua Capital Management LLC | 385.18K | Jun 30, 26 | -- | 5.15% |
| Vestal Point Capital, LP | 304.67K | Jun 30, 26 | -33.94K | 4.07% |
| 5AM Venture Management, LLC | 271.25K | Jun 30, 26 | -116.25K | 3.63% |
| Vivo Capital, LLC | 260.00K | Jun 30, 26 | -- | 3.48% |
| BALYASNY ASSET MANAGEMENT L.P. | 205.03K | Jun 30, 26 | +1.14K | 2.74% |
| GEODE CAPITAL MANAGEMENT, LLC | 201.65K | Jun 30, 26 | +135.80K | 2.70% |
| ACUTA CAPITAL PARTNERS, LLC | 173.40K | Jun 30, 26 | +548 | 2.32% |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133.21K | Jun 30, 26 | -- | 1.78% |
| STATE STREET CORP | 133.08K | Jun 30, 26 | +105.36K | 1.78% |
| GOLDMAN SACHS GROUP INC | 113.53K | Jun 30, 26 | +87.68K | 1.52% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88.65K | Jun 30, 26 | -- | 1.19% |
| Euclidean Capital LLC | 87.70K | Jun 30, 26 | -- | 1.17% |
| TWO SIGMA INVESTMENTS, LP | 71.12K | Jun 30, 26 | +31.64K | 0.95% |
| Stonepine Capital Management, LLC | 68.00K | Jun 30, 26 | +35.00K | 0.91% |
| NORTHERN TRUST CORP | 63.61K | Jun 30, 26 | +51.34K | 0.85% |
| VANGUARD FIDUCIARY TRUST CO | 59.58K | Jun 30, 26 | +24.18K | 0.80% |
| ArrowMark Colorado Holdings LLC | 55.12K | Jun 30, 26 | -- | 0.74% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 51.03K | Jun 30, 26 | +51.03K | 0.68% |
| Eversept Partners, LP | 47.78K | Jun 30, 26 | -10.85K | 0.64% |
| Ellsworth Advisors, LLC | 39.28K | Jun 30, 26 | +39.28K | 0.53% |
| Walleye Capital LLC | 38.83K | Jun 30, 26 | +38.83K | 0.52% |
| BANK OF AMERICA CORP /DE/ | 31.30K | Jun 30, 26 | +31.30K | 0.42% |
| UBS Group AG | 29.23K | Jun 30, 26 | +7.98K | 0.39% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27.74K | Jun 30, 26 | +6.03K | 0.37% |
| FRED ALGER MANAGEMENT, LLC | 24.00K | Jun 30, 26 | -47.69K | 0.32% |
| XTX Topco Ltd | 16.83K | Jun 30, 26 | +16.83K | 0.23% |
| Sixth Street Partners Management Company, L.P. | 16.30K | Jun 30, 26 | +16.30K | 0.22% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16.30K | Jun 30, 26 | +16.30K | 0.22% |
| Bank of New York Mellon Corp | 15.38K | Jun 30, 26 | +15.38K | 0.21% |
| LMR Partners LLP | 13.56K | Jun 30, 26 | -10.00K | 0.18% |
| RENAISSANCE TECHNOLOGIES LLC | 12.37K | Jun 30, 26 | -36.75K | 0.17% |
| Alyeska Investment Group, L.P. | 10.19K | Jun 30, 26 | -- | 0.14% |
| Fisher Asset Management, LLC | 9.84K | Jun 30, 26 | +9.84K | 0.13% |
| Nuveen, LLC | 9.78K | Jun 30, 26 | +9.78K | 0.13% |
| RHUMBLINE ADVISERS | 8.13K | Jun 30, 26 | +8.13K | 0.11% |
| BNP PARIBAS ARBITRAGE, SNC | 8.03K | Jun 30, 26 | +704 | 0.11% |
| DEUTSCHE BANK AG\ | 7.30K | Jun 30, 26 | +7.30K | 0.10% |
| MORGAN STANLEY | 7.15K | Jun 30, 26 | -15.29K | 0.10% |
| WELLS FARGO & COMPANY/MN | 6.70K | Jun 30, 26 | +6.70K | 0.09% |
| MetLife Investment Management, LLC | 4.70K | Jun 30, 26 | +4.70K | 0.06% |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.10K | Jun 30, 26 | +4.10K | 0.05% |
| China Universal Asset Management Co., Ltd. | 3.65K | Jun 30, 26 | +1.15K | 0.05% |
| CITIGROUP INC | 3.46K | Jun 30, 26 | +3.46K | 0.05% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3.38K | Jun 30, 26 | +3.38K | 0.05% |
| JPMORGAN CHASE & CO | 3.04K | Jun 30, 26 | +1.93K | 0.04% |
| Vanguard Global Advisers, LLC | 2.57K | Jun 30, 26 | -- | 0.03% |
| Police & Firemen's Retirement System of New Jersey | 2.17K | Jun 30, 26 | +2.17K | 0.03% |
| BARCLAYS PLC | 1.77K | Jun 30, 26 | -121 | 0.02% |
| ACADIAN ASSET MANAGEMENT LLC | 1.51K | Jun 30, 26 | -- | 0.02% |
| STRS OHIO | 1.40K | Jun 30, 26 | +1.40K | 0.02% |
| Legal & General Group Plc | 715 | Jun 30, 26 | +715 | 0.01% |
| Ameritas Investment Partners, Inc. | 666 | Jun 30, 26 | +666 | 0.01% |
| Russell Investments Group, Ltd. | 587 | Jun 30, 26 | +587 | 0.01% |
| Tower Research Capital LLC (TRC) | 428 | Jun 30, 26 | +427 | 0.01% |
| FMR LLC | 348 | Jun 30, 26 | +348 | 0.00% |
| ROYAL BANK OF CANADA | 311 | Jun 30, 26 | -314 | 0.00% |
| State of Wyoming | 212 | Jun 30, 26 | +212 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 101 | Jun 30, 26 | +101 | 0.00% |
| Sterling Capital Management LLC | 26 | Jun 30, 26 | +26 | 0.00% |
| Caitong International Asset Management Co., Ltd | 1 | Jun 30, 26 | +1 | 0.00% |
| Qube Research & Technologies Ltd | -- | Jun 30, 26 | -14.52K | -- |
| CITADEL ADVISORS LLC | -- | Jun 30, 26 | -35.47K | -- |
| Persistent Asset Partners Ltd | -- | Jun 30, 26 | -7.14K | -- |
| Hudson Bay Capital Management LP | -- | Jun 30, 26 | -8.65K | -- |
| JANE STREET GROUP, LLC | -- | Jun 30, 26 | -7.09K | -- |
| 683 Capital Management, LLC | -- | Jun 30, 26 | -33.00K | -- |
| Woodline Partners LP | -- | Jun 30, 26 | -227.85K | -- |
| FEDERATED HERMES, INC. | -- | Jun 30, 26 | -29 | -- |
| AMERIPRISE FINANCIAL INC | -- | Jun 30, 26 | -159.71K | -- |
| HRT FINANCIAL LP | -- | Jun 30, 26 | -12.15K | -- |
| Ikarian Capital, LLC | -- | Jun 30, 26 | -173.11K | -- |
| BOOTHBAY FUND MANAGEMENT, LLC | -- | Jun 30, 26 | -47.30K | -- |
| MARSHALL WACE, LLP | -- | Jun 30, 26 | -18.93K | -- |
| ADAR1 Capital Management, LLC | -- | Jun 30, 26 | -12.00K | -- |
| SILVERARC CAPITAL MANAGEMENT, LLC | -- | Jun 30, 26 | -144.25K | -- |
| VANGUARD GROUP INC | 319.24K | Dec 31, 25 | +52.82K | 4.27% |
| CVI Holdings, LLC | 64.91K | Jun 30, 24 | +64.91K | 0.87% |
| BlackRock Inc. | 5.68K | Jun 30, 24 | +3.27K | 0.08% |
| Consonance Capital Management LP | 3.50M | Sep 30, 22 | -- | 46.77% |
| Private Capital Group, LLC | -- | Jun 30, 22 | -300 | -- |